Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037971824> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2037971824 endingPage "995" @default.
- W2037971824 startingPage "988" @default.
- W2037971824 abstract "The outcome for 758 consecutive patients who had received one or more chemotherapy regimens for recurrent or metastatic breast cancer is presented. The response rate following first line treatment was 34%. Median duration of response was 7.8 months, median time to progression was 3.7 months and median survival was 7.9 months. The only factor predicting for response, of factors recorded at presentation and at initiation of chemotherapy, was the use of anthracycline based regimens, though this may reflect the patient selection policy. Initial disease free interval, presence of liver metastases and use of anthracyclines were significantly related to time to progression. Several factors related to survival following first chemotherapy, but anthracycline usage showed only a very weak correlation. One third of patients (249/758) received two or more chemotherapy regimens. The response rate (16%) and median time to progression (2.3 months) were significantly worse than for first line treatment. The outcome after third line chemotherapy was very similar to that observed following second line treatment. Achievement of an objective response with first line chemotherapy predicted for second response, but with insufficient power to be of use in selecting patients for subsequent chemotherapy. Time to progression following first line chemotherapy did not influence that after second line treatment." @default.
- W2037971824 created "2016-06-24" @default.
- W2037971824 creator A5002404990 @default.
- W2037971824 creator A5028038008 @default.
- W2037971824 creator A5029971411 @default.
- W2037971824 creator A5054834592 @default.
- W2037971824 creator A5064184281 @default.
- W2037971824 creator A5081913984 @default.
- W2037971824 date "1993-11-01" @default.
- W2037971824 modified "2023-10-09" @default.
- W2037971824 title "Chemotherapy of advanced breast cancer: outcome and prognostic factors" @default.
- W2037971824 cites W1723350107 @default.
- W2037971824 cites W1972348033 @default.
- W2037971824 cites W1974513579 @default.
- W2037971824 cites W1984142569 @default.
- W2037971824 cites W1985609148 @default.
- W2037971824 cites W1987684534 @default.
- W2037971824 cites W1995679782 @default.
- W2037971824 cites W1997249116 @default.
- W2037971824 cites W1999306826 @default.
- W2037971824 cites W2017921725 @default.
- W2037971824 cites W2025110585 @default.
- W2037971824 cites W2038252730 @default.
- W2037971824 cites W2042486582 @default.
- W2037971824 cites W2052281493 @default.
- W2037971824 cites W2081157824 @default.
- W2037971824 cites W2085493687 @default.
- W2037971824 cites W2098521503 @default.
- W2037971824 cites W2137501619 @default.
- W2037971824 cites W2176896925 @default.
- W2037971824 cites W2259257576 @default.
- W2037971824 cites W2265230738 @default.
- W2037971824 cites W2416608956 @default.
- W2037971824 cites W2897079011 @default.
- W2037971824 doi "https://doi.org/10.1038/bjc.1993.467" @default.
- W2037971824 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1968749" @default.
- W2037971824 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8217615" @default.
- W2037971824 hasPublicationYear "1993" @default.
- W2037971824 type Work @default.
- W2037971824 sameAs 2037971824 @default.
- W2037971824 citedByCount "65" @default.
- W2037971824 countsByYear W20379718242012 @default.
- W2037971824 countsByYear W20379718242013 @default.
- W2037971824 countsByYear W20379718242020 @default.
- W2037971824 crossrefType "journal-article" @default.
- W2037971824 hasAuthorship W2037971824A5002404990 @default.
- W2037971824 hasAuthorship W2037971824A5028038008 @default.
- W2037971824 hasAuthorship W2037971824A5029971411 @default.
- W2037971824 hasAuthorship W2037971824A5054834592 @default.
- W2037971824 hasAuthorship W2037971824A5064184281 @default.
- W2037971824 hasAuthorship W2037971824A5081913984 @default.
- W2037971824 hasBestOaLocation W20379718242 @default.
- W2037971824 hasConcept C121608353 @default.
- W2037971824 hasConcept C126322002 @default.
- W2037971824 hasConcept C141071460 @default.
- W2037971824 hasConcept C143998085 @default.
- W2037971824 hasConcept C2775930923 @default.
- W2037971824 hasConcept C2776694085 @default.
- W2037971824 hasConcept C2776802502 @default.
- W2037971824 hasConcept C530470458 @default.
- W2037971824 hasConcept C71924100 @default.
- W2037971824 hasConceptScore W2037971824C121608353 @default.
- W2037971824 hasConceptScore W2037971824C126322002 @default.
- W2037971824 hasConceptScore W2037971824C141071460 @default.
- W2037971824 hasConceptScore W2037971824C143998085 @default.
- W2037971824 hasConceptScore W2037971824C2775930923 @default.
- W2037971824 hasConceptScore W2037971824C2776694085 @default.
- W2037971824 hasConceptScore W2037971824C2776802502 @default.
- W2037971824 hasConceptScore W2037971824C530470458 @default.
- W2037971824 hasConceptScore W2037971824C71924100 @default.
- W2037971824 hasIssue "5" @default.
- W2037971824 hasLocation W20379718241 @default.
- W2037971824 hasLocation W20379718242 @default.
- W2037971824 hasLocation W20379718243 @default.
- W2037971824 hasLocation W20379718244 @default.
- W2037971824 hasOpenAccess W2037971824 @default.
- W2037971824 hasPrimaryLocation W20379718241 @default.
- W2037971824 hasRelatedWork W1966468630 @default.
- W2037971824 hasRelatedWork W2020150632 @default.
- W2037971824 hasRelatedWork W2092771806 @default.
- W2037971824 hasRelatedWork W2166237570 @default.
- W2037971824 hasRelatedWork W2591616149 @default.
- W2037971824 hasRelatedWork W2782589310 @default.
- W2037971824 hasRelatedWork W2791179561 @default.
- W2037971824 hasRelatedWork W2969515167 @default.
- W2037971824 hasRelatedWork W3030794620 @default.
- W2037971824 hasRelatedWork W4212973790 @default.
- W2037971824 hasVolume "68" @default.
- W2037971824 isParatext "false" @default.
- W2037971824 isRetracted "false" @default.
- W2037971824 magId "2037971824" @default.
- W2037971824 workType "article" @default.