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• W2037974177 abstract "Periodontal disease comprises a group of infections that lead to inflammation of the gingival and destruction of periodontal tissues and is accompanied by the loss of the alveolar bone with eventual exfoliation of the teeth. Porphyromonas gingivalis is a Gram-negative bacteria obtained from the periodontal pocket of patients with aggressive and chronic periodontitis. This bacteria presents in the external membrane lipopolysaccharide (LPS). Flavonoids are molecules obtained from plants and possess anti-inflammatory properties. Herein we characterize the effect of the flavonoids quercetin, genistein, luteolin, and quercetagetin on LPS-activated transduction mechanism regulation in human gingival fibroblasts (HGF). In this study, we investigated the role of the previously mentioned flavonoids on mitogen-activated protein kinase (MAPK) activation induced by LPS obtained from P. gingivalis. Our results showed that LPS treatment induces activation of extracellular signal related kinase 1/2 (ERK1/2), p38, and c-jun-NH2-terminal kinase (JNK). All flavonoids demonstrated an inhibitory effect on MAPK activation, interleukin, 1β, and cyclooxygenase-2 (COX-2) expression, IL-1β and prostaglandin E2 (PGE2) synthesis. The most active flavonoid was quercetagetin. Finally we found that the treatment with quercetagetin had no effect on cellular viability or in genetic material integrity." @default.
• W2037974177 created "2016-06-24" @default.
• W2037974177 creator A5037818865 @default.
• W2037974177 creator A5043104771 @default.
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• W2037974177 date "2007-09-01" @default.
• W2037974177 modified "2023-10-02" @default.
• W2037974177 title "The effect of flavonoids on transduction mechanisms in lipopolysaccharide-treated human gingival fibroblasts" @default.
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• W2037974177 doi "https://doi.org/10.1016/j.intimp.2007.05.004" @default.
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