Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037974330> ?p ?o ?g. }
- W2037974330 endingPage "7" @default.
- W2037974330 startingPage "1" @default.
- W2037974330 abstract "Horizontal transmission of prion diseases through the environment represents a considerable concern. Prions are extremely resistant to inactivation and are thought to enter the environment after burial of animal mortalities or through biosolids from wastewater treatment plants. In addition, deposition of prions in the environment through biological fluids and/or faeces has been proved in the last years. Little is known about the behaviour of prion infectivity in the environment. In this study, the persistence of BSE infectious agent in sewage has been assessed by both PrPRes immunoblotting and mouse bioassay in a long-term incubation study. Results indicated that no PrPRes was detected after 150 day of incubation and consistent with this, a statistical regression model estimated 2-logs decay in 151 day. In contrast, no reduction in infectivity was observed during this period. Similarly, BSE infectivity remained unaltered after incubation in PBS for 265 day, whereas PrPRes levels dropped progressively over the length of the study. These results indicate that in sewage and PBS, prion infectivity persists longer and with different dynamics than its commonly used marker PrPRes. Thus, mathematical models computed on the basis of PrPRes detection were unable to predict inactivation of prion infectivity. It is also reasonable to assume that conventional wastewater treatments with low retention times could have a very limited impact on prion infectivity. This data is essential for the development of accurate risk assessment analysis for BSE and other prion diseases in the environment." @default.
- W2037974330 created "2016-06-24" @default.
- W2037974330 creator A5011663846 @default.
- W2037974330 creator A5017989541 @default.
- W2037974330 creator A5035660091 @default.
- W2037974330 creator A5068669818 @default.
- W2037974330 creator A5074976998 @default.
- W2037974330 creator A5082328955 @default.
- W2037974330 date "2012-08-01" @default.
- W2037974330 modified "2023-10-18" @default.
- W2037974330 title "Persistence of the bovine spongiform encephalopathy infectious agent in sewage" @default.
- W2037974330 cites W1557724928 @default.
- W2037974330 cites W1965410549 @default.
- W2037974330 cites W1966948970 @default.
- W2037974330 cites W1969378624 @default.
- W2037974330 cites W1970898725 @default.
- W2037974330 cites W1972802138 @default.
- W2037974330 cites W1975922727 @default.
- W2037974330 cites W1979550663 @default.
- W2037974330 cites W1993380813 @default.
- W2037974330 cites W1995400471 @default.
- W2037974330 cites W1997935103 @default.
- W2037974330 cites W1999511871 @default.
- W2037974330 cites W2014142698 @default.
- W2037974330 cites W2017126556 @default.
- W2037974330 cites W2018656377 @default.
- W2037974330 cites W2022056293 @default.
- W2037974330 cites W2024632347 @default.
- W2037974330 cites W2026261607 @default.
- W2037974330 cites W2036124112 @default.
- W2037974330 cites W2036558774 @default.
- W2037974330 cites W2036689423 @default.
- W2037974330 cites W2042078165 @default.
- W2037974330 cites W2058096709 @default.
- W2037974330 cites W2061005919 @default.
- W2037974330 cites W2061259280 @default.
- W2037974330 cites W2069859543 @default.
- W2037974330 cites W2077455131 @default.
- W2037974330 cites W2077867135 @default.
- W2037974330 cites W2082573664 @default.
- W2037974330 cites W2083657937 @default.
- W2037974330 cites W2083896760 @default.
- W2037974330 cites W2094018868 @default.
- W2037974330 cites W2107538054 @default.
- W2037974330 cites W2121674689 @default.
- W2037974330 cites W2126586779 @default.
- W2037974330 cites W2133762154 @default.
- W2037974330 cites W2136692054 @default.
- W2037974330 cites W2137725220 @default.
- W2037974330 cites W2137852085 @default.
- W2037974330 cites W2138468217 @default.
- W2037974330 cites W2142002352 @default.
- W2037974330 cites W2144337714 @default.
- W2037974330 cites W2152131599 @default.
- W2037974330 cites W2153795602 @default.
- W2037974330 cites W2154336998 @default.
- W2037974330 cites W2161452466 @default.
- W2037974330 cites W2163151366 @default.
- W2037974330 cites W2170192123 @default.
- W2037974330 cites W218529424 @default.
- W2037974330 cites W2324660492 @default.
- W2037974330 doi "https://doi.org/10.1016/j.envres.2012.06.010" @default.
- W2037974330 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22776326" @default.
- W2037974330 hasPublicationYear "2012" @default.
- W2037974330 type Work @default.
- W2037974330 sameAs 2037974330 @default.
- W2037974330 citedByCount "22" @default.
- W2037974330 countsByYear W20379743302013 @default.
- W2037974330 countsByYear W20379743302014 @default.
- W2037974330 countsByYear W20379743302015 @default.
- W2037974330 countsByYear W20379743302016 @default.
- W2037974330 countsByYear W20379743302017 @default.
- W2037974330 countsByYear W20379743302018 @default.
- W2037974330 countsByYear W20379743302019 @default.
- W2037974330 countsByYear W20379743302020 @default.
- W2037974330 countsByYear W20379743302022 @default.
- W2037974330 countsByYear W20379743302023 @default.
- W2037974330 crossrefType "journal-article" @default.
- W2037974330 hasAuthorship W2037974330A5011663846 @default.
- W2037974330 hasAuthorship W2037974330A5017989541 @default.
- W2037974330 hasAuthorship W2037974330A5035660091 @default.
- W2037974330 hasAuthorship W2037974330A5068669818 @default.
- W2037974330 hasAuthorship W2037974330A5074976998 @default.
- W2037974330 hasAuthorship W2037974330A5082328955 @default.
- W2037974330 hasConcept C104488531 @default.
- W2037974330 hasConcept C106358424 @default.
- W2037974330 hasConcept C126322002 @default.
- W2037974330 hasConcept C127413603 @default.
- W2037974330 hasConcept C143701427 @default.
- W2037974330 hasConcept C159047783 @default.
- W2037974330 hasConcept C187320778 @default.
- W2037974330 hasConcept C18903297 @default.
- W2037974330 hasConcept C2522874641 @default.
- W2037974330 hasConcept C25642318 @default.
- W2037974330 hasConcept C2777654200 @default.
- W2037974330 hasConcept C2779134260 @default.
- W2037974330 hasConcept C2780263730 @default.
- W2037974330 hasConcept C2781009140 @default.