FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037979916> ?p ?o ?g. }

• W2037979916 endingPage "607" @default.
• W2037979916 startingPage "600" @default.
• W2037979916 abstract "The main pathological feature of human T-lymphotropic virus type I (HTLV-1)- associated myelopathy/tropical spastic paraparesis (HAWTSP) is chronic inflammation of the spinal cord characterized by perivascular cuffing of mononuclear cells accompanied by parenchymal lymphocytic infiltration. Although the exact mechanism of the pathogenesis of HAWTSP is still obscure, immunological abnormalities arising from a high HTLV-I proviral load in peripheral blood lymphocytes (PBL) play an important role in the pathological process of spinal cord lesions in HAWTSP patients. The relationship between HLA haplotype and the risk of the occurrence of HAWTSP will be elucidated by results from studies of HLA allele typing. In addition, recent data indicate that HTLV-I and its expression are localized in infiltrated lymphocytes within the spinal cord lesions of HAWTSP patients rather than in resident central nervous system (CNS) parenchymal cells. Although a bystander damage of the surrounding CNS tissues, in which CD8+ HTLV-I-specific cytotoxic T lymphocyte (CTL) attack HTLV-I-infected lymphocytes, might be involved in the pathological events of the spinal cords of HAM/ TSP patients as one of the actual pathogenetic mechanisms, heightened transmigrating activity of HTLV-I-infected CD4+ T lymphocytes to the CNS tissues may have a key role in the development of HAM/TSP. Therefore, although the exact mechanism underlying the high HTLV-I proviral load in PBL in HAWTSP patients is still unknown, we must consider therapeutic approaches in HAM/TSP that eliminate HTLV-I-infected CD4+ T lymphocytes." @default.
• W2037979916 created "2016-06-24" @default.
• W2037979916 creator A5081071954 @default.
• W2037979916 date "2000-01-01" @default.
• W2037979916 modified "2023-10-17" @default.
• W2037979916 title "Immunopathogenesis of HTLV-I-associated myelopathy/tropical spastic paraparesis" @default.
• W2037979916 cites W1533983989 @default.
• W2037979916 cites W1586205537 @default.
• W2037979916 cites W1966528056 @default.
• W2037979916 cites W1968228186 @default.
• W2037979916 cites W1968778152 @default.
• W2037979916 cites W1971193812 @default.
• W2037979916 cites W1978771608 @default.
• W2037979916 cites W1979894670 @default.
• W2037979916 cites W1986480844 @default.
• W2037979916 cites W1987228506 @default.
• W2037979916 cites W1990434979 @default.
• W2037979916 cites W1990477022 @default.
• W2037979916 cites W1991941671 @default.
• W2037979916 cites W1994884196 @default.
• W2037979916 cites W1994966401 @default.
• W2037979916 cites W1997706778 @default.
• W2037979916 cites W1998092921 @default.
• W2037979916 cites W1999036331 @default.
• W2037979916 cites W1999039715 @default.
• W2037979916 cites W2003600964 @default.
• W2037979916 cites W2007313776 @default.
• W2037979916 cites W2009166226 @default.
• W2037979916 cites W2010434490 @default.
• W2037979916 cites W2010710421 @default.
• W2037979916 cites W2012542062 @default.
• W2037979916 cites W2015289357 @default.
• W2037979916 cites W2016837741 @default.
• W2037979916 cites W2032992634 @default.
• W2037979916 cites W2033126965 @default.
• W2037979916 cites W2033532477 @default.
• W2037979916 cites W2037355593 @default.
• W2037979916 cites W2037374528 @default.
• W2037979916 cites W2045033555 @default.
• W2037979916 cites W2049594619 @default.
• W2037979916 cites W2052807880 @default.
• W2037979916 cites W2060186266 @default.
• W2037979916 cites W2060239166 @default.
• W2037979916 cites W2067153228 @default.
• W2037979916 cites W2069517404 @default.
• W2037979916 cites W2069667541 @default.
• W2037979916 cites W2073107275 @default.
• W2037979916 cites W2074044733 @default.
• W2037979916 cites W2076165333 @default.
• W2037979916 cites W2080672377 @default.
• W2037979916 cites W2084714153 @default.
• W2037979916 cites W2085195265 @default.
• W2037979916 cites W2088002901 @default.
• W2037979916 cites W2089048401 @default.
• W2037979916 cites W2089876640 @default.
• W2037979916 cites W2095472926 @default.
• W2037979916 cites W2139432296 @default.
• W2037979916 cites W2156456511 @default.
• W2037979916 cites W2157693516 @default.
• W2037979916 cites W2165109848 @default.
• W2037979916 cites W2165581366 @default.
• W2037979916 cites W2167211922 @default.
• W2037979916 cites W2168437273 @default.
• W2037979916 cites W2269404894 @default.
• W2037979916 cites W2336211911 @default.
• W2037979916 cites W2337869677 @default.
• W2037979916 cites W86279991 @default.
• W2037979916 doi "https://doi.org/10.3109/07853890009002030" @default.
• W2037979916 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11209967" @default.
• W2037979916 hasPublicationYear "2000" @default.
• W2037979916 type Work @default.
• W2037979916 sameAs 2037979916 @default.
• W2037979916 citedByCount "24" @default.
• W2037979916 countsByYear W20379799162013 @default.
• W2037979916 countsByYear W20379799162014 @default.
• W2037979916 countsByYear W20379799162018 @default.
• W2037979916 crossrefType "journal-article" @default.
• W2037979916 hasAuthorship W2037979916A5081071954 @default.
• W2037979916 hasConcept C118552586 @default.
• W2037979916 hasConcept C121332964 @default.
• W2037979916 hasConcept C142724271 @default.
• W2037979916 hasConcept C147483822 @default.
• W2037979916 hasConcept C153400128 @default.
• W2037979916 hasConcept C154317977 @default.
• W2037979916 hasConcept C167672396 @default.
• W2037979916 hasConcept C202751555 @default.
• W2037979916 hasConcept C203014093 @default.
• W2037979916 hasConcept C207886595 @default.
• W2037979916 hasConcept C2776368728 @default.
• W2037979916 hasConcept C2776392238 @default.
• W2037979916 hasConcept C2777604421 @default.
• W2037979916 hasConcept C2780775167 @default.
• W2037979916 hasConcept C2780942790 @default.
• W2037979916 hasConcept C55493867 @default.
• W2037979916 hasConcept C71924100 @default.
• W2037979916 hasConcept C86803240 @default.
• W2037979916 hasConcept C97355855 @default.
• W2037979916 hasConceptScore W2037979916C118552586 @default.

• next