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• W2037980112 abstract "The total creatine content of rat extensor digitorum longus (EDL) muscles is reduced from 26.7 m̈mol·g−1 to 5.2 m̈mol·g−1 after 4 weeks on a diet containing b̃-guanidinopropionate. The resting muscles of these animals contain only 5% of the normal creatine phosphate and about 30% of the normal adenosine triphosphate (ATP). Isometric twitch and brief tetanic responses are not significantly different from normal. However, following a 1-second tetanus, the normal twitch potentiation (+80%) is reversed in depleted muscles (−40%). The initial suppression lasts 1–2 seconds and is followed by a small delayed potentiation (+25%). Relaxation rate, which is normally increased following a tetanus, is considerably reduced in depleted muscles. Reversal of potentiation appears to be due to a suppression of twitch activation. The suppression may result from a transient fall in ΔGATP, which is thought to be a critical parameter in the uptake of Ca++ by the sarcoplasmic reticulum (SR)." @default.
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• W2037980112 date "1985-11-01" @default.
• W2037980112 modified "2023-10-14" @default.
• W2037980112 title "Post-tetanic responses in creatine-depleted rat edl muscle" @default.
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• W2037980112 doi "https://doi.org/10.1002/mus.880080906" @default.
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