FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037981504> ?p ?o ?g. }

• W2037981504 endingPage "107" @default.
• W2037981504 startingPage "101" @default.
• W2037981504 abstract "Tumor expression of the proliferation marker (MIB-1) and the cell cycle-related protein (p27) may predict the biologic behavior of various human tumors. The purpose of this study was to evaluate the role of p27 and MIB-1 expression in predicting lymph node metastasis in male breast carcinomas (MBCs). We studied 67 patients with invasive MBC who had undergone modified radical mastectomy. Pathologic lymph node status was correlated with the p27 protein and the MIB-1 proliferation index. These factors were studied immunohistologically by standard methods. Men in this study ranged from 36 to 92 years of age (mean, 63 years); 43 (64%) were T1 lesions, and 24 (36%) were T2 lesions. Twenty-nine patients (43%) had positive nodes. p27 was expressed in 43 tumors (64%) and MIB-1 in 13 tumors (19.4%). Tumors with positive p27 showed positive lymph nodes in 10 cases (23%). In contrast, p27-negative tumors had positive lymph nodes in 18 cases (75%). Tumors positive for MIB-1 show positive lymph nodes in 11 cases (85%). However, when MIB-1 was negative, only 16 patients (30%) had positive lymph nodes. Multivariate logistic regression analysis confirmed the utility of MIB-1 overexpression in predicting lymph node metastasis ( p < 0.0006). Also, decreased p27 protein expression strongly correlates with lymph node metastasis ( p < or = 0.0001). Furthermore, when p27 was negative and MIB-1 was positive, 100% of the patients had positive lymph nodes. In contrast, when p27 was positive and MIB-1 was negative, only 12% of patients had positive lymph nodes. The reduced expression of the p27 protein and the overexpression of the MIB-1 proliferation index in this study show a significant correlation in predicting lymph nodes metastasis in MBCs." @default.
• W2037981504 created "2016-06-24" @default.
• W2037981504 creator A5019967232 @default.
• W2037981504 creator A5022186287 @default.
• W2037981504 creator A5026009695 @default.
• W2037981504 creator A5027900927 @default.
• W2037981504 creator A5030261063 @default.
• W2037981504 creator A5034232647 @default.
• W2037981504 creator A5036209154 @default.
• W2037981504 creator A5055056275 @default.
• W2037981504 creator A5055065582 @default.
• W2037981504 creator A5059300917 @default.
• W2037981504 date "2002-03-01" @default.
• W2037981504 modified "2023-09-27" @default.
• W2037981504 title "Role of Expression of Cell Cycle Inhibitor p27 and MIB-1 in Predicting Lymph Node Metastasis in Male Breast Carcinoma" @default.
• W2037981504 cites W119536604 @default.
• W2037981504 cites W1925212740 @default.
• W2037981504 cites W1967070952 @default.
• W2037981504 cites W1968496151 @default.
• W2037981504 cites W1971254046 @default.
• W2037981504 cites W1984274637 @default.
• W2037981504 cites W1984800492 @default.
• W2037981504 cites W1987008714 @default.
• W2037981504 cites W1987252334 @default.
• W2037981504 cites W1994025314 @default.
• W2037981504 cites W1995425358 @default.
• W2037981504 cites W1998316947 @default.
• W2037981504 cites W1999609514 @default.
• W2037981504 cites W1999819293 @default.
• W2037981504 cites W2002505993 @default.
• W2037981504 cites W2004977101 @default.
• W2037981504 cites W2013965516 @default.
• W2037981504 cites W2015825004 @default.
• W2037981504 cites W2017824326 @default.
• W2037981504 cites W2021457628 @default.
• W2037981504 cites W2028135511 @default.
• W2037981504 cites W2032988198 @default.
• W2037981504 cites W2037761545 @default.
• W2037981504 cites W2038813602 @default.
• W2037981504 cites W2039798401 @default.
• W2037981504 cites W2046946053 @default.
• W2037981504 cites W2047760133 @default.
• W2037981504 cites W2051526950 @default.
• W2037981504 cites W2052955403 @default.
• W2037981504 cites W2055612333 @default.
• W2037981504 cites W2057903965 @default.
• W2037981504 cites W2059178606 @default.
• W2037981504 cites W2067016334 @default.
• W2037981504 cites W2071492334 @default.
• W2037981504 cites W2074070420 @default.
• W2037981504 cites W2079642061 @default.
• W2037981504 cites W2080985976 @default.
• W2037981504 cites W2084128651 @default.
• W2037981504 cites W2092449765 @default.
• W2037981504 cites W2102121261 @default.
• W2037981504 cites W2114508331 @default.
• W2037981504 cites W2128678633 @default.
• W2037981504 cites W2412492985 @default.
• W2037981504 cites W4232207160 @default.
• W2037981504 cites W4238383510 @default.
• W2037981504 cites W4241566922 @default.
• W2037981504 cites W4242650382 @default.
• W2037981504 cites W4247634213 @default.
• W2037981504 cites W4253013087 @default.
• W2037981504 doi "https://doi.org/10.1046/j.1524-4741.2002.08206.x" @default.
• W2037981504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11896756" @default.
• W2037981504 hasPublicationYear "2002" @default.
• W2037981504 type Work @default.
• W2037981504 sameAs 2037981504 @default.
• W2037981504 citedByCount "9" @default.
• W2037981504 countsByYear W20379815042013 @default.
• W2037981504 countsByYear W20379815042016 @default.
• W2037981504 countsByYear W20379815042019 @default.
• W2037981504 countsByYear W20379815042023 @default.
• W2037981504 crossrefType "journal-article" @default.
• W2037981504 hasAuthorship W2037981504A5019967232 @default.
• W2037981504 hasAuthorship W2037981504A5022186287 @default.
• W2037981504 hasAuthorship W2037981504A5026009695 @default.
• W2037981504 hasAuthorship W2037981504A5027900927 @default.
• W2037981504 hasAuthorship W2037981504A5030261063 @default.
• W2037981504 hasAuthorship W2037981504A5034232647 @default.
• W2037981504 hasAuthorship W2037981504A5036209154 @default.
• W2037981504 hasAuthorship W2037981504A5055056275 @default.
• W2037981504 hasAuthorship W2037981504A5055065582 @default.
• W2037981504 hasAuthorship W2037981504A5059300917 @default.
• W2037981504 hasBestOaLocation W20379815041 @default.
• W2037981504 hasConcept C121608353 @default.
• W2037981504 hasConcept C126322002 @default.
• W2037981504 hasConcept C142724271 @default.
• W2037981504 hasConcept C143998085 @default.
• W2037981504 hasConcept C204232928 @default.
• W2037981504 hasConcept C2779013556 @default.
• W2037981504 hasConcept C2779720271 @default.
• W2037981504 hasConcept C2780849966 @default.
• W2037981504 hasConcept C530470458 @default.
• W2037981504 hasConcept C71924100 @default.
• W2037981504 hasConceptScore W2037981504C121608353 @default.
• W2037981504 hasConceptScore W2037981504C126322002 @default.

• next