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- W2037986422 abstract "Acid secretion from isolated and enriched guinea-pig parietal cells stimulated by histamine and measured by the 14C-aminopyrine accumulation technique was enhanced by nanomolar concentrations of D-ala2-D-leu5-enkephalin (DADLE). This effect was blocked by naloxone. Naloxone inhibited histamine-stimulated acid secretion even in the absence of exogenous opioids. The effect of naloxone was stereospecific, i.e. (+)-naloxone was ineffective. The DADLE effect varied between different cell preparations and changed from stimulation to inhibition as the inhibitory effect of naloxone alone increased. Thus, an inverse relationship between the magnitude of inhibition by naloxone and enhancement by DADLE was observed. The data suggest that endogenous opioids modulate acid secretion in gastric mucosal cells." @default.
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- W2037986422 date "1984-01-01" @default.
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- W2037986422 title "Stereospecific Inhibition by Naloxone of Histamine-Stimulated Acid Secretion in Isolated Guinea Pig Parietal Cells" @default.
- W2037986422 doi "https://doi.org/10.1159/000138031" @default.
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