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• W2037989503 abstract "<i>Background/Aims:</i> There is now considerable evidence implicating T cells and macrophages in glomerular injury in crescentic glomerulonephritis. Recently, it has been shown that interleukin-11 (IL-11) has an immune modulatory function through its effect on both macrophages and T cells. We, therefore, examined the therapeutic effect of IL-11 in a murine model of experimental glomerulonephritis. <i>Method:</i> Accelerated nephrotoxic nephritis was induced in C57BL/6 mice. IL-11 at a dose of 0.5 mg/kg/day (n = 10) in vehicle was given daily subcutaneously from the day of sensitization until day 14 after initiation of glomerulonephritis. Control mice (n = 10) received injection of vehicle alone with the same schedule. <i>Results:</i> IL-11 treatment markedly decreased albuminuria (6.2 ± 1.9 vs. 18.2 ± 4.5 mg/day, p < 0.05), the number of glomerular macrophages (1.1 ± 0.2 vs. 1.7 ± 0.3 cells/glomerular cross-section, p < 0.05) and glomerular fibrin deposition (fibrin score 0.9 ± 0.3 vs. 2 ± 0.3, p < 0.05). There was no difference in the glomerular T cell numbers between the IL-11-treated and the vehicle group. Glomerular NF-ĸB activity was markedly suppressed by 75% in the treated group (p = 0.0015). <i>Conclusion:</i> In this study, we provide the first in vivo evidence that IL-11 treatment decreases glomerular NF-ĸB activity and reduces renal injury in experimental glomerulonephritis." @default.
• W2037989503 created "2016-06-24" @default.
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• W2037989503 date "2005-08-30" @default.
• W2037989503 modified "2023-09-26" @default.
• W2037989503 title "Interleukin-11 Reduces Renal Injury and Glomerular NF-Kappa B Activity in Murine Experimental Glomerulonephritis" @default.
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• W2037989503 doi "https://doi.org/10.1159/000087938" @default.
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