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• W2037994279 abstract "Abstract Previous data from two‐stage carcinogenesis studies in mouse skin demonstrated that genetic control of susceptibility to skin tumor promotion by the phorbol ester, 12‐O‐tetradecanoylphorbol‐13‐acetate (TPA), in crosses between susceptible DBA/2J and resistant C57BL/6J mice is a multigenic trait. Utilizing a cDNA microarray approach, we compared global gene expression profiles in the epidermis of these two mouse strains treated with TPA or vehicle (acetone). Gene expression in the epidermis was analyzed after the treatment to identify global effects of TPA, as well as potential candidate genes that modify susceptibility to skin tumor promotion. DBA/2J and C57BL/6J mice were treated topically four times with 3.4 nmol TPA or acetone over a 2‐wk period, and RNA was extracted from epidermis 6 h after the final treatment. Labeled cDNA generated from each group was hybridized to commercial cDNA microarrays (Agilent) containing more than 8000 targets. More than 450 genes were significantly influenced, directly or indirectly, by TPA treatment in the epidermis of either strain. Notably, 44 genes exhibited differential expression between the tumor promotion sensitive and resistant mouse strains. Several genes that were differentially expressed in DBA/2J versus C57BL/6J epidermis after TPA treatment were located in chromosomal regions linked to TPA promotion susceptibility. Three genes, Gsta4 , Nmes1 ( MGC58382 ), and Serpinb2 , located within promotion susceptibility loci Psl1 (chr 9), Psl2 (chr 2), and Psl3 (chr 1), respectively, were identified in this analysis as potential candidates for modifiers of susceptibility to skin tumor promotion by TPA. © 2005 Wiley‐Liss, Inc." @default.
• W2037994279 created "2016-06-24" @default.
• W2037994279 creator A5018804324 @default.
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• W2037994279 creator A5086525008 @default.
• W2037994279 date "2005-07-25" @default.
• W2037994279 modified "2023-10-10" @default.
• W2037994279 title "Differential gene expression in epidermis of mice sensitive and resistant to phorbol ester skin tumor promotion" @default.
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• W2037994279 doi "https://doi.org/10.1002/mc.20127" @default.
• W2037994279 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16044405" @default.
• W2037994279 hasPublicationYear "2005" @default.
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