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- W2037995718 abstract "Biochemical assessment of antidepressive drugs in man is usually focused on the evaluation of these drugs’ interactions with biogenic amines and their receptors. There are two main reasons for this. Firstly, almost all antidepressive drugs possess one or more effects on these amines. Monoamine oxidase (MAO) inhibitors reduce the rate of their metabolism (Glowinski, Hamon, Javoy & Morot Gaudry, 1972), tricyclic antidepressive (TCA) drugs inhibit their reuptake at the nerve terminals (Iversen, 1965), and lithium salts increase the reuptake of noradrenaline (NA) by synaptosomes (Colburn, Goodwin, Bunney & Davis, 1967). It is generally believed that these drugs act by increasing the amount of functional monoamines present in the synaptic cleft, and indeed this had been the basis for ‘biogenic amine hypothesis of depression’ (Schildkraut, 1965; Coppen, 1970). Although during recent years many investigators have become doubtful about the validity of this simple hypothesis (Ghose & Coppen, 1977; Leonard, 1980), it is now being argued that depressive disorders are biochemically heterogenous conditions where deficiency of either 5-hydroxytryptamine (5-HT) or NA is the primary aetiological factor (Asberg, Thoren, Traskman & Bertilsson, 1975; Maas, 1975)." @default.
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- W2037995718 date "1980-12-01" @default.
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- W2037995718 title "Biochemical assessment of antidepressive drugs." @default.
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- W2037995718 doi "https://doi.org/10.1111/j.1365-2125.1980.tb00508.x" @default.
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