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- W2037998978 abstract "Experiments examined effects of extracellular Mg2+ concentration (Mgo2+) on dose-dependent actions of strophanthidin, norepinephrine, Bay K-8644 and extracellular Ca2+ (Cao2+) in electrically stimulated atrial and ventricular muscle isolated from guinea pig heart. Mgo2+ itself elicited a concentration-dependent negative inotropic effect. Elevation of Mgo2+ between 0.6 and 12 mM increased the concentration of strophanthidin necessary to produce its toxic effects without affecting the maximum developed tension prior to toxicity. Similarly, Mgo2+ did not alter the maximum contractile force elicited by cumulative addition of norepinephrine, Bay K-8644 or Cao2+, but increased their ED50 values. These data suggest that interactions between Mgo2+ and the four positive inotropic agents were not mediated by effects on receptor binding or Na+,K+-ATPase, but rather by alterations at one or more steps involved in excitation-contraction coupling." @default.
- W2037998978 created "2016-06-24" @default.
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- W2037998978 date "1989-06-01" @default.
- W2037998978 modified "2023-09-23" @default.
- W2037998978 title "Effects of buffer magnesium on positive inotropic agents in guinea pig cardiac muscle" @default.
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- W2037998978 doi "https://doi.org/10.1016/0014-2999(89)90711-5" @default.
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