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• W2037999444 abstract "Summary: There are two distinct pathways by which T cells may MHC alloantigens. The direct pathway involves T-cell recognition of intact MHC molecules expressed by donor antigen-presenting cells (APCs). The second, or indirect, pathway describes T-cell recognition of peptides derived from the processing and presentation of allogeneic MHC molecules on self APCs. Recent data demonstrates that indirect recognition plays a central role in both acute and chronic rejection of human organ allografts. Our studies have shown that, at the onset of primary acute rejection, recipient T-cell responses lo donor HLA-DR alloantigens are limited to a single dominant determinant present on erne of the disparate alloantigens and restricted by one of the responder's HLA-DR molecules. In allograft recipients with recurring episodes of rejection, and/or at the onset of chronic rejection, recipient T-cell reactivity may spread lo other epitopes within the allogeneic MHC molecule as well as to other alloantigens expressed by graft tissue. Both quantitative and qualitative alterations in T-cell allopeptide reactivity are associated with increased risk of cellular and/or humoral rejection. These studies provide a basis for the design of new therapeutic strategies and for immunologic monitoring of transplant recipients." @default.
• W2037999444 created "2016-06-24" @default.
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• W2037999444 creator A5026609346 @default.
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• W2037999444 date "1998-08-01" @default.
• W2037999444 modified "2023-10-18" @default.
• W2037999444 title "Intramolecular and intermolecular spreading during the course of organ allograft rejection" @default.
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• W2037999444 doi "https://doi.org/10.1111/j.1600-065x.1998.tb01224.x" @default.
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