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Matches in SemOpenAlex for { <https://semopenalex.org/work/W203800209> ?p ?o ?g. }

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• W203800209 abstract "Caspase-3 (CASP3) plays a key role in apoptosis. In this study, HAX-1 was identified as a new substrate of CASP3 during apoptosis. HAX-1 was cleaved by CASP3 during etoposide-(ETO) induced apoptosis, and this event was inhibited by a CASP3-specific inhibitor. The cleavage site of HAX-1, at Asp(127), was located using N-terminal amino acid sequencing of in vitro cleavage products of recombinant HAX-1. Overexpression of HAX-1 inhibited ETO-induced apoptotic cell death. It also inhibited CASP3 activity. Together, these results suggest that HAX-1, a substrate of CASP3, inhibits the apoptotic process by inhibiting CASP3 activity." @default.
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• W203800209 date "2008-02-29" @default.
• W203800209 modified "2023-10-17" @default.
• W203800209 title "HS 1-associated protein X-1 is cleaved by caspase-3 during apoptosis." @default.
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• W203800209 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18319618" @default.
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