FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2038007029> ?p ?o ?g. }

• W2038007029 endingPage "97" @default.
• W2038007029 startingPage "93" @default.
• W2038007029 abstract "Angiomatoid fibrous histiocytoma is a mesenchymal neoplasm of intermediate malignancy and uncertain histogenesis/line of differentiation, which occurs most commonly in the extremities of children to young adults. It has a characteristic appearance characterized by a proliferation of histiocytoid cells with a lymphoid cuff and fibrous pseudocapsule, simulating the appearance of a neoplasm occurring within a lymph node. However, these classic histological features are not always present. Given the variable appearance of the neoplastic cells and the lack of consistently positive immunohistochemical markers, diagnosis can be problematic. Angiomatoid fibrous histiocytoma has been found to harbor three related translocations, a t(12;16)(q13;p11) resulting in a FUS/ATF1 fusion gene, t(12;22)(q13;q12) resulting in a EWSR1/ATF1 fusion, and t(2;22)(q33;q12) resulting in a EWSR1/CREB1 fusion. Fluorescence in situ hybridization (FISH) probes to EWSR1 and FUS, in theory, should detect all three translocations/gene fusions. We evaluated 18 cases of angiomatoid fibrous histiocytoma for rearrangements of EWSR1 and FUS by FISH, the largest series to date. We found that 13 of 17 (76%) cases of angiomatoid fibrous histiocytoma harbored rearrangements of EWSR1; rearrangements of FUS were not detected in any of the cases. This study affirms that the rearrangement of EWSR1 is a common genetic event in angiomatoid fibrous histiocytoma, and is thus useful diagnostically. This study supports the fact that the rearrangement of FUS is present in only a small minority of angiomatoid fibrous histiocytomas. Interestingly, 24% of the cases were translocation negative, and did not contain rearrangements of EWSR1 or FUS by FISH. Although it is possible that these cases contained cryptic rearrangements of EWSR1 or FUS that were not detectable by our FISH probes, it also raises the possibility that another translocation/gene fusion may be present in angiomatoid fibrous histiocytoma. Finally, we discuss some of the potential pitfalls of this technique, including confusion with other mesenchymal neoplasms containing rearrangement of EWSR1, in particular Ewing's sarcoma/PNET." @default.
• W2038007029 created "2016-06-24" @default.
• W2038007029 creator A5001267176 @default.
• W2038007029 creator A5014593516 @default.
• W2038007029 creator A5022726531 @default.
• W2038007029 creator A5035007884 @default.
• W2038007029 creator A5035251468 @default.
• W2038007029 creator A5059707915 @default.
• W2038007029 creator A5066731616 @default.
• W2038007029 creator A5084269123 @default.
• W2038007029 date "2010-01-01" @default.
• W2038007029 modified "2023-09-30" @default.
• W2038007029 title "Utility of FISH in the diagnosis of angiomatoid fibrous histiocytoma: a series of 18 cases" @default.
• W2038007029 cites W1973455501 @default.
• W2038007029 cites W1997726097 @default.
• W2038007029 cites W2046853984 @default.
• W2038007029 cites W2063396252 @default.
• W2038007029 cites W2075301995 @default.
• W2038007029 cites W2075630997 @default.
• W2038007029 cites W2079002177 @default.
• W2038007029 cites W2080903243 @default.
• W2038007029 cites W2092289690 @default.
• W2038007029 cites W2109213959 @default.
• W2038007029 cites W2119244589 @default.
• W2038007029 cites W2151363438 @default.
• W2038007029 cites W2158966764 @default.
• W2038007029 cites W2329786496 @default.
• W2038007029 doi "https://doi.org/10.1038/modpathol.2009.138" @default.
• W2038007029 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19801966" @default.
• W2038007029 hasPublicationYear "2010" @default.
• W2038007029 type Work @default.
• W2038007029 sameAs 2038007029 @default.
• W2038007029 citedByCount "63" @default.
• W2038007029 countsByYear W20380070292012 @default.
• W2038007029 countsByYear W20380070292013 @default.
• W2038007029 countsByYear W20380070292014 @default.
• W2038007029 countsByYear W20380070292015 @default.
• W2038007029 countsByYear W20380070292016 @default.
• W2038007029 countsByYear W20380070292017 @default.
• W2038007029 countsByYear W20380070292018 @default.
• W2038007029 countsByYear W20380070292019 @default.
• W2038007029 countsByYear W20380070292020 @default.
• W2038007029 countsByYear W20380070292021 @default.
• W2038007029 countsByYear W20380070292022 @default.
• W2038007029 countsByYear W20380070292023 @default.
• W2038007029 crossrefType "journal-article" @default.
• W2038007029 hasAuthorship W2038007029A5001267176 @default.
• W2038007029 hasAuthorship W2038007029A5014593516 @default.
• W2038007029 hasAuthorship W2038007029A5022726531 @default.
• W2038007029 hasAuthorship W2038007029A5035007884 @default.
• W2038007029 hasAuthorship W2038007029A5035251468 @default.
• W2038007029 hasAuthorship W2038007029A5059707915 @default.
• W2038007029 hasAuthorship W2038007029A5066731616 @default.
• W2038007029 hasAuthorship W2038007029A5084269123 @default.
• W2038007029 hasBestOaLocation W20380070291 @default.
• W2038007029 hasConcept C104317684 @default.
• W2038007029 hasConcept C111829193 @default.
• W2038007029 hasConcept C138626823 @default.
• W2038007029 hasConcept C142724271 @default.
• W2038007029 hasConcept C191548132 @default.
• W2038007029 hasConcept C204232928 @default.
• W2038007029 hasConcept C2776295783 @default.
• W2038007029 hasConcept C2777542201 @default.
• W2038007029 hasConcept C2779399171 @default.
• W2038007029 hasConcept C2780635560 @default.
• W2038007029 hasConcept C2780849966 @default.
• W2038007029 hasConcept C2992511266 @default.
• W2038007029 hasConcept C30481170 @default.
• W2038007029 hasConcept C54355233 @default.
• W2038007029 hasConcept C71924100 @default.
• W2038007029 hasConcept C86803240 @default.
• W2038007029 hasConceptScore W2038007029C104317684 @default.
• W2038007029 hasConceptScore W2038007029C111829193 @default.
• W2038007029 hasConceptScore W2038007029C138626823 @default.
• W2038007029 hasConceptScore W2038007029C142724271 @default.
• W2038007029 hasConceptScore W2038007029C191548132 @default.
• W2038007029 hasConceptScore W2038007029C204232928 @default.
• W2038007029 hasConceptScore W2038007029C2776295783 @default.
• W2038007029 hasConceptScore W2038007029C2777542201 @default.
• W2038007029 hasConceptScore W2038007029C2779399171 @default.
• W2038007029 hasConceptScore W2038007029C2780635560 @default.
• W2038007029 hasConceptScore W2038007029C2780849966 @default.
• W2038007029 hasConceptScore W2038007029C2992511266 @default.
• W2038007029 hasConceptScore W2038007029C30481170 @default.
• W2038007029 hasConceptScore W2038007029C54355233 @default.
• W2038007029 hasConceptScore W2038007029C71924100 @default.
• W2038007029 hasConceptScore W2038007029C86803240 @default.
• W2038007029 hasIssue "1" @default.
• W2038007029 hasLocation W20380070291 @default.
• W2038007029 hasLocation W20380070292 @default.
• W2038007029 hasOpenAccess W2038007029 @default.
• W2038007029 hasPrimaryLocation W20380070291 @default.
• W2038007029 hasRelatedWork W1990301753 @default.
• W2038007029 hasRelatedWork W2007375220 @default.
• W2038007029 hasRelatedWork W2016514994 @default.
• W2038007029 hasRelatedWork W2025412898 @default.
• W2038007029 hasRelatedWork W2027419106 @default.
• W2038007029 hasRelatedWork W2152043134 @default.

• next