FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2038014760> ?p ?o ?g. }

• W2038014760 endingPage "7282" @default.
• W2038014760 startingPage "7277" @default.
• W2038014760 abstract "Type B streptogramins, such as virginiamycin S (VS), are cyclic hexadepsipeptides, inhibiting protein synthesis in prokaryotes. L-Thr connects a 3-hydroxypicolinyl residue (3-OH-Pic) to the peptide lactone ring. The fluorescence intensity of 3-OH-Pic is strongly increased by chelation to alkaline earth cations or binding to ribosomes. Similar behavior of the ribosome-VS complex and the VS-Mg chelate provides strong evidence for the presence of a VS-Mg chelate within the ribosomal binding site. Different models involving the ribosome binding of either members of the VS-Mg2+ chelate or both have been tested by fluorescence lifetime measurements, equilibrium titrations, and stopped-flow spectrofluorometry. Our data strongly suggest that (a) the interaction between VS and the ribosome is partly provided by a salt bridge between suitable acceptor atoms of the ribosome and the 3-OH-Pic residue, (b) Mg2+ can be exchanged by Mn2+ without dissociation of the ribosome-VS complex, (c) Mg2+ coordinates to the negative form of the 3-OH-Pic residue, probably via an interaction with the phenolate oxygen and the amide carboxyl group, and (d) the picolinyl residue is essential for the biological activity, as indicated by the lack of activity when the latter is replaced by a serine derivative." @default.
• W2038014760 created "2016-06-24" @default.
• W2038014760 creator A5045314838 @default.
• W2038014760 creator A5061926187 @default.
• W2038014760 creator A5077665205 @default.
• W2038014760 creator A5080939439 @default.
• W2038014760 creator A5089347522 @default.
• W2038014760 date "1991-07-23" @default.
• W2038014760 modified "2023-10-14" @default.
• W2038014760 title "Interaction between virginiamycin S and ribosomes is partly provided by a salt bridge with a magnesium ion" @default.
• W2038014760 cites W1510434718 @default.
• W2038014760 cites W1516665537 @default.
• W2038014760 cites W1656224656 @default.
• W2038014760 cites W1686868547 @default.
• W2038014760 cites W1732030651 @default.
• W2038014760 cites W1967253354 @default.
• W2038014760 cites W1969648021 @default.
• W2038014760 cites W1975088764 @default.
• W2038014760 cites W1975587222 @default.
• W2038014760 cites W1988423725 @default.
• W2038014760 cites W1991256461 @default.
• W2038014760 cites W1992072526 @default.
• W2038014760 cites W1995012068 @default.
• W2038014760 cites W1996060070 @default.
• W2038014760 cites W2001411640 @default.
• W2038014760 cites W2011013535 @default.
• W2038014760 cites W2012832520 @default.
• W2038014760 cites W2021817288 @default.
• W2038014760 cites W2024957115 @default.
• W2038014760 cites W2026213158 @default.
• W2038014760 cites W2033915462 @default.
• W2038014760 cites W2035029869 @default.
• W2038014760 cites W2053391308 @default.
• W2038014760 cites W2072173244 @default.
• W2038014760 cites W2088221289 @default.
• W2038014760 cites W2089727025 @default.
• W2038014760 cites W2093903579 @default.
• W2038014760 cites W2179869959 @default.
• W2038014760 cites W2322498040 @default.
• W2038014760 cites W2887904943 @default.
• W2038014760 cites W996891806 @default.
• W2038014760 doi "https://doi.org/10.1021/bi00243a033" @default.
• W2038014760 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1906740" @default.
• W2038014760 hasPublicationYear "1991" @default.
• W2038014760 type Work @default.
• W2038014760 sameAs 2038014760 @default.
• W2038014760 citedByCount "10" @default.
• W2038014760 countsByYear W20380147602018 @default.
• W2038014760 crossrefType "journal-article" @default.
• W2038014760 hasAuthorship W2038014760A5045314838 @default.
• W2038014760 hasAuthorship W2038014760A5061926187 @default.
• W2038014760 hasAuthorship W2038014760A5077665205 @default.
• W2038014760 hasAuthorship W2038014760A5080939439 @default.
• W2038014760 hasAuthorship W2038014760A5089347522 @default.
• W2038014760 hasConcept C104317684 @default.
• W2038014760 hasConcept C107824862 @default.
• W2038014760 hasConcept C114847915 @default.
• W2038014760 hasConcept C143065580 @default.
• W2038014760 hasConcept C178790620 @default.
• W2038014760 hasConcept C179104552 @default.
• W2038014760 hasConcept C184866935 @default.
• W2038014760 hasConcept C185592680 @default.
• W2038014760 hasConcept C197404232 @default.
• W2038014760 hasConcept C2778439535 @default.
• W2038014760 hasConcept C2781338088 @default.
• W2038014760 hasConcept C30765947 @default.
• W2038014760 hasConcept C543218039 @default.
• W2038014760 hasConcept C55493867 @default.
• W2038014760 hasConcept C67705224 @default.
• W2038014760 hasConcept C71240020 @default.
• W2038014760 hasConcept C88478588 @default.
• W2038014760 hasConcept C96267730 @default.
• W2038014760 hasConceptScore W2038014760C104317684 @default.
• W2038014760 hasConceptScore W2038014760C107824862 @default.
• W2038014760 hasConceptScore W2038014760C114847915 @default.
• W2038014760 hasConceptScore W2038014760C143065580 @default.
• W2038014760 hasConceptScore W2038014760C178790620 @default.
• W2038014760 hasConceptScore W2038014760C179104552 @default.
• W2038014760 hasConceptScore W2038014760C184866935 @default.
• W2038014760 hasConceptScore W2038014760C185592680 @default.
• W2038014760 hasConceptScore W2038014760C197404232 @default.
• W2038014760 hasConceptScore W2038014760C2778439535 @default.
• W2038014760 hasConceptScore W2038014760C2781338088 @default.
• W2038014760 hasConceptScore W2038014760C30765947 @default.
• W2038014760 hasConceptScore W2038014760C543218039 @default.
• W2038014760 hasConceptScore W2038014760C55493867 @default.
• W2038014760 hasConceptScore W2038014760C67705224 @default.
• W2038014760 hasConceptScore W2038014760C71240020 @default.
• W2038014760 hasConceptScore W2038014760C88478588 @default.
• W2038014760 hasConceptScore W2038014760C96267730 @default.
• W2038014760 hasIssue "29" @default.
• W2038014760 hasLocation W20380147601 @default.
• W2038014760 hasLocation W20380147602 @default.
• W2038014760 hasOpenAccess W2038014760 @default.
• W2038014760 hasPrimaryLocation W20380147601 @default.
• W2038014760 hasRelatedWork W1973316864 @default.
• W2038014760 hasRelatedWork W1982214418 @default.
• W2038014760 hasRelatedWork W2001411640 @default.

• next