Matches in SemOpenAlex for { <https://semopenalex.org/work/W2038014794> ?p ?o ?g. }
- W2038014794 endingPage "1224" @default.
- W2038014794 startingPage "1196" @default.
- W2038014794 abstract "Induction of drug-clearance pathways (Phase 1 and 2 enzymes and transporters) can have important clinical consequences. Inducers can (1) increase the clearance of other drugs, resulting in a decreased therapeutic effect, (2) increase the activation of pro-drugs, causing an alteration in their efficacy and pharmacokinetics, and (3) increase the bioactivation of drugs that contribute to hepatotoxicity via reactive intermediates. Nuclear receptors are key mediators of drug-induced changes in the expression of drug-clearance pathways. However, species differences in nuclear receptor activation make the prediction of cytochrome P450 (CYP) induction in humans from data derived from animal models problematic. Thus, in vitro human-relevant model systems are increasingly used to evaluate enzyme induction. In this review, the authors' current understanding of the mechanisms of enzyme induction and the in vitro methods for assessing the induction potential of new drugs will be discussed. Relevant issues and considerations surrounding proper study design and the interpretation of in vitro results will be discussed in light of the current US Food and Drug Administration (FDA) recommendations." @default.
- W2038014794 created "2016-06-24" @default.
- W2038014794 creator A5026959014 @default.
- W2038014794 creator A5034858563 @default.
- W2038014794 creator A5055889724 @default.
- W2038014794 date "2007-11-01" @default.
- W2038014794 modified "2023-09-30" @default.
- W2038014794 title "Induction of hepatic cytochrome P450 enzymes: methods, mechanisms, recommendations, and<b><i>in vitro–in vivo</i></b>correlations" @default.
- W2038014794 cites W1004452157 @default.
- W2038014794 cites W1482551660 @default.
- W2038014794 cites W1570746601 @default.
- W2038014794 cites W1606649779 @default.
- W2038014794 cites W1697791488 @default.
- W2038014794 cites W1758547589 @default.
- W2038014794 cites W183837874 @default.
- W2038014794 cites W1848082114 @default.
- W2038014794 cites W1964291693 @default.
- W2038014794 cites W1964838425 @default.
- W2038014794 cites W1966210362 @default.
- W2038014794 cites W1966948651 @default.
- W2038014794 cites W1967325600 @default.
- W2038014794 cites W1967782384 @default.
- W2038014794 cites W1968535758 @default.
- W2038014794 cites W1970396159 @default.
- W2038014794 cites W1971106062 @default.
- W2038014794 cites W1973238763 @default.
- W2038014794 cites W1980455299 @default.
- W2038014794 cites W198065351 @default.
- W2038014794 cites W1981230656 @default.
- W2038014794 cites W1981797192 @default.
- W2038014794 cites W1984574841 @default.
- W2038014794 cites W1990244492 @default.
- W2038014794 cites W1991812553 @default.
- W2038014794 cites W1995775426 @default.
- W2038014794 cites W1996620463 @default.
- W2038014794 cites W1997264947 @default.
- W2038014794 cites W1997271604 @default.
- W2038014794 cites W1999532678 @default.
- W2038014794 cites W2000581994 @default.
- W2038014794 cites W2002739002 @default.
- W2038014794 cites W2003445644 @default.
- W2038014794 cites W2006179299 @default.
- W2038014794 cites W2006360771 @default.
- W2038014794 cites W2009330082 @default.
- W2038014794 cites W2010519104 @default.
- W2038014794 cites W2013594177 @default.
- W2038014794 cites W2019334085 @default.
- W2038014794 cites W2024675404 @default.
- W2038014794 cites W2027517951 @default.
- W2038014794 cites W2027561440 @default.
- W2038014794 cites W2028273026 @default.
- W2038014794 cites W2028673146 @default.
- W2038014794 cites W2029294514 @default.
- W2038014794 cites W2031241298 @default.
- W2038014794 cites W2035168432 @default.
- W2038014794 cites W2037083778 @default.
- W2038014794 cites W2040567225 @default.
- W2038014794 cites W2043660751 @default.
- W2038014794 cites W2044911368 @default.
- W2038014794 cites W2054030734 @default.
- W2038014794 cites W2056334141 @default.
- W2038014794 cites W2057626046 @default.
- W2038014794 cites W2059588998 @default.
- W2038014794 cites W2061061025 @default.
- W2038014794 cites W2062934575 @default.
- W2038014794 cites W2063539617 @default.
- W2038014794 cites W2071354571 @default.
- W2038014794 cites W2074373793 @default.
- W2038014794 cites W2076578237 @default.
- W2038014794 cites W2081532782 @default.
- W2038014794 cites W2084462922 @default.
- W2038014794 cites W2089338956 @default.
- W2038014794 cites W2095203795 @default.
- W2038014794 cites W2098293164 @default.
- W2038014794 cites W2099352274 @default.
- W2038014794 cites W2099575771 @default.
- W2038014794 cites W2103020094 @default.
- W2038014794 cites W2108665729 @default.
- W2038014794 cites W2108911961 @default.
- W2038014794 cites W2109499383 @default.
- W2038014794 cites W2111325313 @default.
- W2038014794 cites W2112052557 @default.
- W2038014794 cites W2114622977 @default.
- W2038014794 cites W2114756989 @default.
- W2038014794 cites W2119678057 @default.
- W2038014794 cites W2120467119 @default.
- W2038014794 cites W2123370748 @default.
- W2038014794 cites W2125270482 @default.
- W2038014794 cites W2127041435 @default.
- W2038014794 cites W2128266687 @default.
- W2038014794 cites W2133352191 @default.
- W2038014794 cites W2136560821 @default.
- W2038014794 cites W2143194676 @default.
- W2038014794 cites W2143926676 @default.
- W2038014794 cites W2148083393 @default.
- W2038014794 cites W2148590099 @default.
- W2038014794 cites W2149102781 @default.
- W2038014794 cites W2149929188 @default.