FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2038021239> ?p ?o ?g. }

• W2038021239 abstract "The effects of various phorbol-based protein kinase C (PKC) activators on the electrical stimulation-induced (S-I) release of serotonin and acetylcholine was studied in rat brain cortical slices pre-incubated with [3H]-serotonin or [3H]-choline to investigate possible structure-activity relationships. 4beta-phorbol 12,13-dibutyrate (4betaPDB, 0.1-3.0 microM), enhanced S-I release of serotonin in a concentration-dependent manner whereas the structurally related inactive isomer 4alpha-phorbol 12, 13-dibutyrate (4alphaPDB) and phorbol 13-acetate (PA) were without effect. Another group of phorbol esters containing a common 13-ester substituent (phorbol 12,13-diacetate, PDA; phorbol 12-myristate 13-acetate, PMA; phorbol 12-methylaminobenzoate 13-acetate, PMBA) also enhanced S-I serotonin release with PMA being least potent. The deoxyphorbol monoesters, 12-deoxyphorbol 13-acetate (dPA), 12-deoxyphorbol 13-angelate (dPAng), 12-deoxyphorbol 13-phenylacetate (dPPhen) and 12-deoxyphorbol 13-isobutyrate (dPiB) enhanced S-I serotonin release but 12-deoxyphorbol 13-tetradecanoate (dPT) was without effect. The 20-acetate derivatives of dPPhen and dPAng were less effective in enhancing S-I serotonin release compared to the parent compounds. With acetylcholine release all phorbol esters tested had a far lesser effect when compared to their facilitatory action on serotonin release with only 4betaPDB, PDA, dPA, dPAng and dPiB having significant effects. The effects of the phorbol esters on serotonin release were not correlated with their reported in vitro affinity and isozyme selectivity for PKC. A comparison across three transmitter systems (noradrenaline, dopamine, serotonin) suggests basic similarities in the structural requirements of phorbol esters to enhance transmitter release with short chain substituted mono- and diesters of phorbol being more potent facilitators of release than the long chain esters. Some compounds notably PDA, PMBA, dPPhen, dPPhenA had different potencies across noradrenaline, dopamine and serotonin." @default.
• W2038021239 created "2016-06-24" @default.
• W2038021239 creator A5009454947 @default.
• W2038021239 creator A5029412174 @default.
• W2038021239 creator A5050661550 @default.
• W2038021239 date "1999-07-01" @default.
• W2038021239 modified "2023-09-24" @default.
• W2038021239 title "The structural requirements for phorbol esters to enhance serotonin and acetylcholine release from rat brain cortex" @default.
• W2038021239 cites W1522765298 @default.
• W2038021239 cites W1760081200 @default.
• W2038021239 cites W1848995654 @default.
• W2038021239 cites W196035950 @default.
• W2038021239 cites W1968335787 @default.
• W2038021239 cites W1970521537 @default.
• W2038021239 cites W1974947963 @default.
• W2038021239 cites W1978223897 @default.
• W2038021239 cites W2003235357 @default.
• W2038021239 cites W2008510420 @default.
• W2038021239 cites W2011459199 @default.
• W2038021239 cites W2017025918 @default.
• W2038021239 cites W2024147080 @default.
• W2038021239 cites W2036264640 @default.
• W2038021239 cites W2043342501 @default.
• W2038021239 cites W2043445106 @default.
• W2038021239 cites W2044546864 @default.
• W2038021239 cites W2049175900 @default.
• W2038021239 cites W2063928717 @default.
• W2038021239 cites W2066853820 @default.
• W2038021239 cites W2068735225 @default.
• W2038021239 cites W2079097093 @default.
• W2038021239 cites W2081680614 @default.
• W2038021239 cites W2083892313 @default.
• W2038021239 cites W2085708078 @default.
• W2038021239 cites W2086524338 @default.
• W2038021239 cites W2102153963 @default.
• W2038021239 cites W2131524293 @default.
• W2038021239 cites W2161798777 @default.
• W2038021239 cites W2196524012 @default.
• W2038021239 cites W2330420700 @default.
• W2038021239 cites W2333818140 @default.
• W2038021239 cites W4211131955 @default.
• W2038021239 doi "https://doi.org/10.1038/sj.bjp.0702627" @default.
• W2038021239 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1566109" @default.
• W2038021239 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10455264" @default.
• W2038021239 hasPublicationYear "1999" @default.
• W2038021239 type Work @default.
• W2038021239 sameAs 2038021239 @default.
• W2038021239 citedByCount "5" @default.
• W2038021239 countsByYear W20380212392019 @default.
• W2038021239 crossrefType "journal-article" @default.
• W2038021239 hasAuthorship W2038021239A5009454947 @default.
• W2038021239 hasAuthorship W2038021239A5029412174 @default.
• W2038021239 hasAuthorship W2038021239A5050661550 @default.
• W2038021239 hasBestOaLocation W20380212392 @default.
• W2038021239 hasConcept C11960822 @default.
• W2038021239 hasConcept C126322002 @default.
• W2038021239 hasConcept C134018914 @default.
• W2038021239 hasConcept C170493617 @default.
• W2038021239 hasConcept C185592680 @default.
• W2038021239 hasConcept C195794163 @default.
• W2038021239 hasConcept C2775864247 @default.
• W2038021239 hasConcept C2775910092 @default.
• W2038021239 hasConcept C2776219046 @default.
• W2038021239 hasConcept C2780043322 @default.
• W2038021239 hasConcept C55493867 @default.
• W2038021239 hasConcept C71924100 @default.
• W2038021239 hasConcept C86803240 @default.
• W2038021239 hasConcept C98274493 @default.
• W2038021239 hasConceptScore W2038021239C11960822 @default.
• W2038021239 hasConceptScore W2038021239C126322002 @default.
• W2038021239 hasConceptScore W2038021239C134018914 @default.
• W2038021239 hasConceptScore W2038021239C170493617 @default.
• W2038021239 hasConceptScore W2038021239C185592680 @default.
• W2038021239 hasConceptScore W2038021239C195794163 @default.
• W2038021239 hasConceptScore W2038021239C2775864247 @default.
• W2038021239 hasConceptScore W2038021239C2775910092 @default.
• W2038021239 hasConceptScore W2038021239C2776219046 @default.
• W2038021239 hasConceptScore W2038021239C2780043322 @default.
• W2038021239 hasConceptScore W2038021239C55493867 @default.
• W2038021239 hasConceptScore W2038021239C71924100 @default.
• W2038021239 hasConceptScore W2038021239C86803240 @default.
• W2038021239 hasConceptScore W2038021239C98274493 @default.
• W2038021239 hasLocation W20380212391 @default.
• W2038021239 hasLocation W20380212392 @default.
• W2038021239 hasLocation W20380212393 @default.
• W2038021239 hasLocation W20380212394 @default.
• W2038021239 hasOpenAccess W2038021239 @default.
• W2038021239 hasPrimaryLocation W20380212391 @default.
• W2038021239 hasRelatedWork W1577309327 @default.
• W2038021239 hasRelatedWork W1595579667 @default.
• W2038021239 hasRelatedWork W1935980239 @default.
• W2038021239 hasRelatedWork W1964097733 @default.
• W2038021239 hasRelatedWork W1975000176 @default.
• W2038021239 hasRelatedWork W1975286344 @default.
• W2038021239 hasRelatedWork W1989777352 @default.
• W2038021239 hasRelatedWork W2005585268 @default.
• W2038021239 hasRelatedWork W2016023701 @default.
• W2038021239 hasRelatedWork W2023002433 @default.
• W2038021239 hasRelatedWork W2036264640 @default.
• W2038021239 hasRelatedWork W2048702522 @default.

• next