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• W2038047187 abstract "Purpose.: We tested the hypothesis that there are age- and race-related differences in posterior scleral material properties, using eyes from human donors of European (20–90 years old, n = 40 eyes) and African (23–74 years old, n = 22 eyes) descent. Methods.: Inflation tests on posterior scleral shells were performed while full-field, three-dimensional displacements were recorded using laser speckle interferometry. Scleral material properties were fit to each eye using a microstructure-based constitutive formulation that incorporates the collagen fibril crimp and the local anisotropic collagen architecture. The effects of age and race were estimated using Generalized Estimating Equations, while accounting for intradonor correlations. Results.: The shear modulus significantly increased (P = 0.038) and collagen fibril crimp angle significantly decreased with age (P = 0.002). Donors of African descent exhibited a significantly higher shear modulus (P = 0.019) and showed evidence of a smaller collagen fibril crimp angle (P = 0.057) compared to donors of European descent. The in-plane strains in the peripapillary sclera were significantly lower with age (P < 0.015) and African ancestry (P < 0.015). Conclusions.: The age- and race-related differences in scleral material properties result in a loss of scleral compliance due to a higher shear stiffness and a lower level of stretch at which the collagen fibrils uncrimp. The loss of compliance should lead to larger high frequency IOP fluctuations and changes in the optic nerve head (ONH) biomechanical response in the elderly and in persons of African ancestry, and may contribute to the higher susceptibility to glaucoma in these at-risk populations." @default.
• W2038047187 created "2016-06-24" @default.
• W2038047187 creator A5030554277 @default.
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• W2038047187 date "2014-11-11" @default.
• W2038047187 modified "2023-10-14" @default.
• W2038047187 title "Age- and Race-Related Differences in Human Scleral Material Properties" @default.
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• W2038047187 doi "https://doi.org/10.1167/iovs.14-14029" @default.
• W2038047187 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4266082" @default.
• W2038047187 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25389203" @default.
• W2038047187 hasPublicationYear "2014" @default.
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