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• W2038049007 abstract "l-Cycloserine dose-dependently inhibited the activity of γ-aminobutyric acid (GABA)-transaminase (GABA-T) and elevated the level of GABA in whole mouse brain with a peak effect 3–4 hr after a single intraperitoneal injection. At a dose (30 mgkg) which elevated the level of GABA almost 4-fold, l-cycloserine moderately increased the content of alanine and slightly reduced that of aspartate, glutamate and glycine in the brain. l-Cycloserine (10–30 mgkg, p.o. or i.p.) prevented tonic seizures induced by 3-mercaptopropionic acid (3-MPA) and audiogenic seizures in DBA/2 mice, without affecting those evoked by pentylenetetrazol, bicuculline and electroshock. Similarly small doses of l-cycloserine reduced the level of cGMP in the cerebellum of rats, prevented its elevation by 3-MPA and attenuated the hypothalamically-elicited rage reaction in cats. Larger doses of l-cycloserine ( > 30–100 mgkg) impaired the performance of mice in the rotarod, chimney and horizontal wire tests, and reduced spontaneous locomotor activity of rats. Upon repeated administration the inhibitory effect of l-cycloserine on the activity of GABA-T and on seizures elicited by 3-MPA in mice increased. In contrast, the depressant action of l-cycloserine on motor performance and locomotion declined in subchronically-treated mice and rats. The levels of amino acids in brain after repeated administration did not differ markedly from those in acutely-treated mice. It is suggested that small doses of l-cycloserine, probably by increasing GABAergic inhibition, reduce hyperexcitability in the brain in acute- and subchronically-treated animals. Larger doses of l-cycloserine, possibly by inducing multiple neurochemical changes, evoke central depressant effects which diminish during subchronic treatment." @default.
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• W2038049007 date "1986-04-01" @default.
• W2038049007 modified "2023-09-26" @default.
• W2038049007 title "l-Cycloserine: Behavioural and biochemical effects after single and repeated administration to mice, rats and cats" @default.
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• W2038049007 doi "https://doi.org/10.1016/0028-3908(86)90236-4" @default.
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