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- W2038049093 abstract "Ventriculocisternal administration of dl- and d-propranolol produced dose-dependent increases in cerebrospinal fluid norepinephrine and reductions in blood pressure. A highly significant correlation was found between the increase in norepinephrine and the hypotensive effect. The propranolol-induced hypotension was prevented by intracisternal phentolamine. These data indicate that the hypotensive effect of centrally administered propranolol results from a drug-induced release of norepinephrine, which stimulates central alpha receptors to lower arterial pressure." @default.
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- W2038049093 date "1981-08-21" @default.
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- W2038049093 title "Cerebroventricular Propranolol Elevates Cerebrospinal Fluid Norepinephrine and Lowers Blood Pressure" @default.
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- W2038049093 doi "https://doi.org/10.1126/science.7256285" @default.
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