FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2038049686> ?p ?o ?g. }

• W2038049686 endingPage "10895" @default.
• W2038049686 startingPage "10886" @default.
• W2038049686 abstract "The vast increase in available data from the “-omics” revolution has enabled the fields of structural proteomics and structure prediction to make great progress in assigning realistic three-dimensional structures to each protein molecule. The challenge now lies in determining the fine structural details that endow unique functions to sequences that assume a common fold. Similar problems are encountered in understanding how distinct conformations contribute to different phases of a single protein's dynamic function. However, efforts are hampered by the complexity of these large, three-dimensional molecules. To overcome this limitation, structural data have been recast as two-dimensional networks. This analysis greatly reduces visual complexity but retains information about individual residues. Such diagrams are very useful for comparing multiple structures, including (1) homologous proteins, (2) time points throughout a dynamics simulation, and (3) functionally different conformations of a given protein. Enhanced structural examination results in new functional hypotheses to test experimentally. Here, network representations were key to discerning a difference between unliganded and inducer-bound lactose repressor protein (LacI), which were previously presumed to be identical structures. Further, the interface of unliganded LacI was surprisingly similar to that of the K84L variant and various structures generated by molecular dynamics simulations. Apo-LacI appears to be poised to adopt the conformation of either the DNA- or inducer-bound structures, and the K84L mutation appears to freeze the structure partway through the conformational transition. Additional examination of the effector binding pocket results in specific hypotheses about how inducer, anti-inducer, and neutral sugars exert their effects on repressor function." @default.
• W2038049686 created "2016-06-24" @default.
• W2038049686 creator A5035852381 @default.
• W2038049686 date "2004-08-01" @default.
• W2038049686 modified "2023-09-23" @default.
• W2038049686 title "Using Networks To Identify Fine Structural Differences between Functionally Distinct Protein States" @default.
• W2038049686 cites W1487286309 @default.
• W2038049686 cites W1497443366 @default.
• W2038049686 cites W1501151513 @default.
• W2038049686 cites W1513908748 @default.
• W2038049686 cites W1523367337 @default.
• W2038049686 cites W1588856937 @default.
• W2038049686 cites W1987958688 @default.
• W2038049686 cites W2004576601 @default.
• W2038049686 cites W2010260387 @default.
• W2038049686 cites W2014201888 @default.
• W2038049686 cites W2015093279 @default.
• W2038049686 cites W2017323082 @default.
• W2038049686 cites W2023137092 @default.
• W2038049686 cites W2032619610 @default.
• W2038049686 cites W2037184756 @default.
• W2038049686 cites W2056197139 @default.
• W2038049686 cites W2070871842 @default.
• W2038049686 cites W2090432482 @default.
• W2038049686 cites W2117932491 @default.
• W2038049686 cites W2134328540 @default.
• W2038049686 cites W2142401849 @default.
• W2038049686 cites W2162166182 @default.
• W2038049686 cites W2320909563 @default.
• W2038049686 cites W2329156357 @default.
• W2038049686 cites W2905826917 @default.
• W2038049686 cites W94247581 @default.
• W2038049686 doi "https://doi.org/10.1021/bi049450k" @default.
• W2038049686 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15323549" @default.
• W2038049686 hasPublicationYear "2004" @default.
• W2038049686 type Work @default.
• W2038049686 sameAs 2038049686 @default.
• W2038049686 citedByCount "33" @default.
• W2038049686 countsByYear W20380496862012 @default.
• W2038049686 countsByYear W20380496862013 @default.
• W2038049686 countsByYear W20380496862015 @default.
• W2038049686 countsByYear W20380496862016 @default.
• W2038049686 countsByYear W20380496862018 @default.
• W2038049686 countsByYear W20380496862020 @default.
• W2038049686 countsByYear W20380496862023 @default.
• W2038049686 crossrefType "journal-article" @default.
• W2038049686 hasAuthorship W2038049686A5035852381 @default.
• W2038049686 hasConcept C104317684 @default.
• W2038049686 hasConcept C113629113 @default.
• W2038049686 hasConcept C12554922 @default.
• W2038049686 hasConcept C14036430 @default.
• W2038049686 hasConcept C147597530 @default.
• W2038049686 hasConcept C158448853 @default.
• W2038049686 hasConcept C185592680 @default.
• W2038049686 hasConcept C186060115 @default.
• W2038049686 hasConcept C2225953 @default.
• W2038049686 hasConcept C47701112 @default.
• W2038049686 hasConcept C51785407 @default.
• W2038049686 hasConcept C54355233 @default.
• W2038049686 hasConcept C55493867 @default.
• W2038049686 hasConcept C59593255 @default.
• W2038049686 hasConcept C70721500 @default.
• W2038049686 hasConcept C86339819 @default.
• W2038049686 hasConcept C86803240 @default.
• W2038049686 hasConceptScore W2038049686C104317684 @default.
• W2038049686 hasConceptScore W2038049686C113629113 @default.
• W2038049686 hasConceptScore W2038049686C12554922 @default.
• W2038049686 hasConceptScore W2038049686C14036430 @default.
• W2038049686 hasConceptScore W2038049686C147597530 @default.
• W2038049686 hasConceptScore W2038049686C158448853 @default.
• W2038049686 hasConceptScore W2038049686C185592680 @default.
• W2038049686 hasConceptScore W2038049686C186060115 @default.
• W2038049686 hasConceptScore W2038049686C2225953 @default.
• W2038049686 hasConceptScore W2038049686C47701112 @default.
• W2038049686 hasConceptScore W2038049686C51785407 @default.
• W2038049686 hasConceptScore W2038049686C54355233 @default.
• W2038049686 hasConceptScore W2038049686C55493867 @default.
• W2038049686 hasConceptScore W2038049686C59593255 @default.
• W2038049686 hasConceptScore W2038049686C70721500 @default.
• W2038049686 hasConceptScore W2038049686C86339819 @default.
• W2038049686 hasConceptScore W2038049686C86803240 @default.
• W2038049686 hasIssue "34" @default.
• W2038049686 hasLocation W20380496861 @default.
• W2038049686 hasLocation W20380496862 @default.
• W2038049686 hasOpenAccess W2038049686 @default.
• W2038049686 hasPrimaryLocation W20380496861 @default.
• W2038049686 hasRelatedWork W1505031824 @default.
• W2038049686 hasRelatedWork W1588856937 @default.
• W2038049686 hasRelatedWork W2038049686 @default.
• W2038049686 hasRelatedWork W2062528482 @default.
• W2038049686 hasRelatedWork W2073682227 @default.
• W2038049686 hasRelatedWork W2152920762 @default.
• W2038049686 hasRelatedWork W2162008182 @default.
• W2038049686 hasRelatedWork W2171546080 @default.
• W2038049686 hasRelatedWork W4248926100 @default.
• W2038049686 hasRelatedWork W96299284 @default.
• W2038049686 hasVolume "43" @default.
• W2038049686 isParatext "false" @default.

• next