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- W2038050576 abstract "ABSTRACT A functional as well as quantitative assessment of the peripheral T-lymphocytes was made in 90 patients with various forms of thyroid diseases, 43 with Graves' disease (GD), 23 with non-toxic multinodular goitre (NTMG), 18 with toxic nodular goitre (TNG) and 12 with well-differentiated thyroid cancer (TC), using the E rosette-forming test and the local graft-versus-host reaction (GVHR). Forty healthy volunteers served as controls. In addition, the glands removed from the 38 patients who underwent operation were evaluated histologically for lymphocytic infiltration. The percentage of E rosette-forming cells was found to be significantly lower than normal (58.0 ± 9.03) in the patients with GD (48.7 ± 9.83, P <0.01), NTMG (47.61 ± 12.34, P < 0.01) and TNG (48.8 ± 11.1, P < 0.02). The absolute T-cell count was significantly lower than normal (1207 ± 443) in the patients with GD (973 ± 331, P < 0.05) and NTMG (890 ± 360, P <0.02). The GVHR was completely negative or weakly positive in only 2 of the 40 (5 %) controls, in 14 of the 39 (35.9 %) patients with GD, 14 of the 23 (60.8 %) with NTMG, 9 of the 17 (53 %) with TNG and 3 of the 12 (25 %) with TC. The amount of lymphocytic infiltration in the surgical specimen showed no correlation with the T-cell count and GVHR of the peripheral blood lymphocytes of the patients. Analysis of the data in the group as a whole also failed to reveal any correlation between the GVHR and E rosette test. The GVHR is a functional test while the E rosette is a quantitative test. The findings of this study indicate that there is an impairment in the functional activity of the T-lymphocytes, patients with nodular goitre having shown a more pronounced impairment of cell-mediated immunity than those with GD and TC." @default.
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- W2038050576 date "1979-01-01" @default.
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- W2038050576 title "QUANTITATIVE AND FUNCTIONAL ASSESSMENT OF PERIPHERAL T-LYMPHOCYTES IN THYROID DISEASES" @default.
- W2038050576 doi "https://doi.org/10.1530/acta.0.0900052" @default.
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