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• W2038051646 abstract "Neuronal variability plays a central role in neural coding and impacts the dynamics of neuronal networks. Unreliability of synaptic transmission is a major source of neural variability: synaptic neurotransmitter vesicles are released probabilistically in response to presynaptic action potentials and are recovered stochastically in time. The dynamics of this process of vesicle release and recovery interacts with variability in the arrival times of presynaptic spikes to shape the variability of the postsynaptic response. We use continuous time Markov chain methods to analyze a model of short term synaptic depression with stochastic vesicle dynamics coupled with three different models of presynaptic spiking: one model in which the timing of presynaptic action potentials are modeled as a Poisson process, one in which action potentials occur more regularly than a Poisson process (sub-Poisson) and one in which action potentials occur more irregularly (super-Poisson). We use this analysis to investigate how variability in a presynaptic spike train is transformed by short term depression and stochastic vesicle dynamics to determine the variability of the postsynaptic response. We find that sub-Poisson presynaptic spiking increases the average rate at which vesicles are released, that the number of vesicles released over a time window is more variable for smaller time windows than larger time windows and that fast presynaptic spiking gives rise to Poisson-like variability of the postsynaptic response even when presynaptic spike times are non-Poisson. Our results complement and extend previously reported theoretical results and provide possible explanations for some trends observed in recorded data." @default.
• W2038051646 created "2016-06-24" @default.
• W2038051646 creator A5035370639 @default.
• W2038051646 creator A5063334369 @default.
• W2038051646 date "2013-01-26" @default.
• W2038051646 modified "2023-09-25" @default.
• W2038051646 title "The impact of short term synaptic depression and stochastic vesicle dynamics on neuronal variability" @default.
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• W2038051646 doi "https://doi.org/10.1007/s10827-012-0438-0" @default.
• W2038051646 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4528672" @default.
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• W2038051646 hasPublicationYear "2013" @default.
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