Matches in SemOpenAlex for { <https://semopenalex.org/work/W2038055963> ?p ?o ?g. }
- W2038055963 endingPage "1097" @default.
- W2038055963 startingPage "1092" @default.
- W2038055963 abstract "Recent groundbreaking discoveries have revealed that IGF-1, Ras, MEK, AMPK, TSC1/2, FOXO, PI3K, mTOR, S6K, and NFκB are involved in the aging process. This is remarkable because the same signaling molecules, oncoproteins and tumor suppressors, are well-known targets for cancer therapy. Furthermore, anti-cancer drugs aimed at some of these targets have been already developed. This arsenal could be potentially employed for anti-aging interventions (given that similar signaling molecules are involved in both cancer and aging). In cancer, intrinsic and acquired resistance, tumor heterogeneity, adaptation, and genetic instability of cancer cells all hinder cancer-directed therapy. But for anti-aging applications, these hurdles are irrelevant. For example, since anti-aging interventions should be aimed at normal postmitotic cells, no selection for resistance is expected. At low doses, certain agents may decelerate aging and age-related diseases. Importantly, deceleration of aging can in turn postpone cancer, which is an age-related disease." @default.
- W2038055963 created "2016-06-24" @default.
- W2038055963 creator A5045764409 @default.
- W2038055963 date "2013-12-01" @default.
- W2038055963 modified "2023-09-27" @default.
- W2038055963 title "Selective anti-cancer agents as anti-aging drugs" @default.
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