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- W2038075425 abstract "Gene therapy is expected to have a major impact on human healthcare in the future. However, precise regulation of therapeutic gene expression in vivo is still a challenge. Natural and synthetic enhancer-promoters (EPs) can be utilized to drive gene transcription in a temporal, spatial or environmental signal-inducible manner in response to heat shock, hypoxia, radiation, chemotherapy, epigenetic agents or viral infection. To allow tightly regulated expression, a regulatable gene-expression system can also be implemented. Most of these systems are based on small molecule (drug)-responsive artificial transactivators. In this review, we aim to provide a brief overview of the classes of EPs and regulatable systems, along with lessons learned from these studies. We highlight the potential applications in gene transfer, gene therapy for cancer and genetic disease and the future challenges for clinical applications." @default.
- W2038075425 created "2016-06-24" @default.
- W2038075425 creator A5018214782 @default.
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- W2038075425 creator A5051030840 @default.
- W2038075425 creator A5069771802 @default.
- W2038075425 creator A5088980073 @default.
- W2038075425 date "2008-09-01" @default.
- W2038075425 modified "2023-10-16" @default.
- W2038075425 title "Gene transfer: the challenge of regulated gene expression" @default.
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