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• W2038084500 endingPage "247" @default.
• W2038084500 startingPage "229" @default.
• W2038084500 abstract "Antimutator alleles indentify genes whose normal products are involved in spontaneous mutagenesis pathways. Mutant alleles of the recA and umuC genes of Escherichia coli, whose wild-type alleles are components of the inducible SOS response, were shown to cause a decrease in the level of spontaneous mutagenesis. Using a series of chromosomal mutant trp alleles, which detect point mutations, as a reversion assay, it was shown that the reduction in mutagenesis is limited to base-pair substitutions. Within the limited number of sites than could be examined, transversions at AT sites were the favored substitutions. Frameshift mutagenesis was slightly enhanced by a mutant recA allele and unchanged by a mutant umuC allele. The wild-type recA and umuC genes are involved in the same mutagenic base-pair substitution pathway, designated SOS-dependent spontaneous mutagenesis (SDSM), since a recAumuC strain showed the same degree and specificity of antimutator activity as either single mutant strain. The SDSM pathway is active only in the presence of oxygen, since wild-type, recA, and umuC strains all show the same levels of reduced spontaneous mutagenesis anaerobically. The SDSM pathway can function in starving/stationary cells and may, or may not, be operative in actively dividing cultures. We suggest that, in wild-type cells, SDSM results from basal levels of SOS activity during DNA synthesis. Mutations may result from synthesis past cryptic DNA lesions (targeted mutagenesis) and/or from mispairings during synthesis with a normal DNA template (untargeted mutagenesis). Since it occurs in chromosomal genes of wild-type cells, SDSM may be biologically significant for isolates of natural enteric bacterial populations where extended starvation is often a common mode of existence." @default.
• W2038084500 created "2016-06-24" @default.
• W2038084500 creator A5028492619 @default.
• W2038084500 creator A5036732737 @default.
• W2038084500 creator A5042299178 @default.
• W2038084500 creator A5067500333 @default.
• W2038084500 creator A5041626731 @default.
• W2038084500 date "2001-02-01" @default.
• W2038084500 modified "2023-10-14" @default.
• W2038084500 title "An aerobic recA-, umuC-dependent pathway of spontaneous base-pair substitution mutagenesis in Escherichia coli" @default.
• W2038084500 cites W1486946238 @default.
• W2038084500 cites W1504228646 @default.
• W2038084500 cites W1525162460 @default.
• W2038084500 cites W1531713383 @default.
• W2038084500 cites W1554316156 @default.
• W2038084500 cites W1573258101 @default.
• W2038084500 cites W1581260181 @default.
• W2038084500 cites W1584586118 @default.
• W2038084500 cites W1593010321 @default.
• W2038084500 cites W1605943440 @default.
• W2038084500 cites W1782193066 @default.
• W2038084500 cites W1831436375 @default.
• W2038084500 cites W1832974928 @default.
• W2038084500 cites W1848310822 @default.
• W2038084500 cites W1871462509 @default.
• W2038084500 cites W1901933893 @default.
• W2038084500 cites W1903000287 @default.
• W2038084500 cites W1912686435 @default.
• W2038084500 cites W1913707695 @default.
• W2038084500 cites W1915370682 @default.
• W2038084500 cites W1958219879 @default.
• W2038084500 cites W1960610464 @default.
• W2038084500 cites W1964111587 @default.
• W2038084500 cites W1967128130 @default.
• W2038084500 cites W1969503199 @default.
• W2038084500 cites W1974210160 @default.
• W2038084500 cites W1976036531 @default.
• W2038084500 cites W1976324655 @default.
• W2038084500 cites W1981379092 @default.
• W2038084500 cites W1983322124 @default.
• W2038084500 cites W1984290310 @default.
• W2038084500 cites W1984367999 @default.
• W2038084500 cites W1987639095 @default.
• W2038084500 cites W1989847011 @default.
• W2038084500 cites W1992597955 @default.
• W2038084500 cites W1994203491 @default.
• W2038084500 cites W1995568065 @default.
• W2038084500 cites W1996693838 @default.
• W2038084500 cites W1997340461 @default.
• W2038084500 cites W1998397625 @default.
• W2038084500 cites W2000130187 @default.
• W2038084500 cites W2000486309 @default.
• W2038084500 cites W2000709611 @default.
• W2038084500 cites W2005655417 @default.
• W2038084500 cites W2007934299 @default.
• W2038084500 cites W2011874363 @default.
• W2038084500 cites W2013240923 @default.
• W2038084500 cites W2014442287 @default.
• W2038084500 cites W2015408684 @default.
• W2038084500 cites W2023244472 @default.
• W2038084500 cites W2023586087 @default.
• W2038084500 cites W2027960467 @default.
• W2038084500 cites W2028629048 @default.
• W2038084500 cites W2033168020 @default.
• W2038084500 cites W2034827817 @default.
• W2038084500 cites W2035819908 @default.
• W2038084500 cites W2035849178 @default.
• W2038084500 cites W2037184450 @default.
• W2038084500 cites W2037722651 @default.
• W2038084500 cites W2037757201 @default.
• W2038084500 cites W2038211892 @default.
• W2038084500 cites W2039977871 @default.
• W2038084500 cites W2040149655 @default.
• W2038084500 cites W2041770319 @default.
• W2038084500 cites W2041787577 @default.
• W2038084500 cites W2043259679 @default.
• W2038084500 cites W2043748488 @default.
• W2038084500 cites W2046304818 @default.
• W2038084500 cites W2049848181 @default.
• W2038084500 cites W2056672240 @default.
• W2038084500 cites W2058259339 @default.
• W2038084500 cites W2063628220 @default.
• W2038084500 cites W2063940042 @default.
• W2038084500 cites W2067726213 @default.
• W2038084500 cites W2068572804 @default.
• W2038084500 cites W2069646948 @default.
• W2038084500 cites W2075095457 @default.
• W2038084500 cites W2077531231 @default.
• W2038084500 cites W2078484033 @default.
• W2038084500 cites W2081458979 @default.
• W2038084500 cites W2082494697 @default.
• W2038084500 cites W2085031141 @default.
• W2038084500 cites W2085831108 @default.
• W2038084500 cites W2088367556 @default.
• W2038084500 cites W2089672074 @default.
• W2038084500 cites W2091330414 @default.
• W2038084500 cites W2092796102 @default.
• W2038084500 cites W2096533833 @default.

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