FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2038093962> ?p ?o ?g. }

• W2038093962 endingPage "135" @default.
• W2038093962 startingPage "125" @default.
• W2038093962 abstract "The neurophysiological changes that occur during pregnancy in the female mammal have led to the coining of the phrases “expectant brain” and “maternal brain”. Although much is known of the hormonal changes during pregnancy, alterations in neurotransmitter gene expression have not been well-studied. We examined gene expression in the ventromedial nucleus of the hypothalamus (VMH) during pregnancy based on the fact that this nucleus not only modulates the physiological changes that occur during pregnancy but is also involved in the development of maternal behavior. This study was designed to identify genes that are differentially expressed between mid- and late-pregnancy in order to determine which genes may be associated with the onset and display of maternal behavior and the development of the maternal brain. A commercially available PCR array containing 84 neurotransmitter receptor and regulator genes (RT2 Profiler PCR array) was used. Brains were harvested from rats on days 12 and 21 of gestation, frozen, and micropunched to obtain the VMH. Total RNA was extracted, cDNA prepared, and SYBR Green qPCR was performed. In the VMH, expression of five genes were reduced on day 21 of gestation compared to day 12 (Chrna6, Drd5, Gabrr2, Prokr2, and Ppyr1) whereas Chat, Chrm5, Drd4, Gabra5, Gabrg2, LOC289606, Nmu5r2, and Npy5r expression was elevated. Five genes were chosen to be validated in an additional experiment based on their known involvement in maternal behavior onset. This experiment confirmed that gene expression for both the CCK-A receptor and the GABAAR γ2 receptor increases at the end of pregnancy. In general, these results identify genes possibly involved in the establishment of the maternal brain in rats and indicate possible new genes to be investigated." @default.
• W2038093962 created "2016-06-24" @default.
• W2038093962 creator A5028734695 @default.
• W2038093962 date "2014-03-04" @default.
• W2038093962 modified "2023-09-25" @default.
• W2038093962 title "Gene Expression Profiling during Pregnancy in Rat Brain Tissue" @default.
• W2038093962 cites W1485903578 @default.
• W2038093962 cites W1553000526 @default.
• W2038093962 cites W1833869665 @default.
• W2038093962 cites W1967770554 @default.
• W2038093962 cites W1971893944 @default.
• W2038093962 cites W1974684041 @default.
• W2038093962 cites W1981237424 @default.
• W2038093962 cites W1984680121 @default.
• W2038093962 cites W1989839926 @default.
• W2038093962 cites W1996283925 @default.
• W2038093962 cites W1997494395 @default.
• W2038093962 cites W1998703496 @default.
• W2038093962 cites W2002975752 @default.
• W2038093962 cites W2005096597 @default.
• W2038093962 cites W2008362441 @default.
• W2038093962 cites W2010495392 @default.
• W2038093962 cites W2012696656 @default.
• W2038093962 cites W2014324757 @default.
• W2038093962 cites W2019433313 @default.
• W2038093962 cites W2024088369 @default.
• W2038093962 cites W2031658048 @default.
• W2038093962 cites W2032962404 @default.
• W2038093962 cites W2034812041 @default.
• W2038093962 cites W2042143038 @default.
• W2038093962 cites W2042805820 @default.
• W2038093962 cites W2043551756 @default.
• W2038093962 cites W2046417492 @default.
• W2038093962 cites W2048292960 @default.
• W2038093962 cites W2049319049 @default.
• W2038093962 cites W2053307562 @default.
• W2038093962 cites W2054736158 @default.
• W2038093962 cites W2055383557 @default.
• W2038093962 cites W2059171188 @default.
• W2038093962 cites W2061570803 @default.
• W2038093962 cites W2063349842 @default.
• W2038093962 cites W2065199415 @default.
• W2038093962 cites W2065307305 @default.
• W2038093962 cites W2081619557 @default.
• W2038093962 cites W2085929544 @default.
• W2038093962 cites W2087014724 @default.
• W2038093962 cites W2107277218 @default.
• W2038093962 cites W2108977243 @default.
• W2038093962 cites W2114600335 @default.
• W2038093962 cites W2130793280 @default.
• W2038093962 cites W2139628190 @default.
• W2038093962 cites W2141861222 @default.
• W2038093962 cites W2147339597 @default.
• W2038093962 cites W2156546713 @default.
• W2038093962 cites W4233572796 @default.
• W2038093962 cites W4239121644 @default.
• W2038093962 cites W4245406608 @default.
• W2038093962 cites W97280282 @default.
• W2038093962 doi "https://doi.org/10.3390/brainsci4010125" @default.
• W2038093962 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4066241" @default.
• W2038093962 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24961703" @default.
• W2038093962 hasPublicationYear "2014" @default.
• W2038093962 type Work @default.
• W2038093962 sameAs 2038093962 @default.
• W2038093962 citedByCount "7" @default.
• W2038093962 countsByYear W20380939622016 @default.
• W2038093962 countsByYear W20380939622017 @default.
• W2038093962 countsByYear W20380939622018 @default.
• W2038093962 countsByYear W20380939622021 @default.
• W2038093962 crossrefType "journal-article" @default.
• W2038093962 hasAuthorship W2038093962A5028734695 @default.
• W2038093962 hasBestOaLocation W20380939621 @default.
• W2038093962 hasConcept C104317684 @default.
• W2038093962 hasConcept C126322002 @default.
• W2038093962 hasConcept C134018914 @default.
• W2038093962 hasConcept C150194340 @default.
• W2038093962 hasConcept C156927020 @default.
• W2038093962 hasConcept C170493617 @default.
• W2038093962 hasConcept C18431079 @default.
• W2038093962 hasConcept C2776046087 @default.
• W2038093962 hasConcept C2776219046 @default.
• W2038093962 hasConcept C2777003273 @default.
• W2038093962 hasConcept C2779234561 @default.
• W2038093962 hasConcept C46973012 @default.
• W2038093962 hasConcept C529278444 @default.
• W2038093962 hasConcept C54355233 @default.
• W2038093962 hasConcept C71924100 @default.
• W2038093962 hasConcept C86803240 @default.
• W2038093962 hasConceptScore W2038093962C104317684 @default.
• W2038093962 hasConceptScore W2038093962C126322002 @default.
• W2038093962 hasConceptScore W2038093962C134018914 @default.
• W2038093962 hasConceptScore W2038093962C150194340 @default.
• W2038093962 hasConceptScore W2038093962C156927020 @default.
• W2038093962 hasConceptScore W2038093962C170493617 @default.
• W2038093962 hasConceptScore W2038093962C18431079 @default.
• W2038093962 hasConceptScore W2038093962C2776046087 @default.
• W2038093962 hasConceptScore W2038093962C2776219046 @default.
• W2038093962 hasConceptScore W2038093962C2777003273 @default.

• next