FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2038107959> ?p ?o ?g. }

• W2038107959 endingPage "93" @default.
• W2038107959 startingPage "77" @default.
• W2038107959 abstract "Background A limited evidence exists regarding comparisons of clinical effectiveness of available therapies for first-line treatment of chronic lymphocytic leukemia (CLL). Methods We compared available therapies for treatment-naïve, symptomatic CLL regarding progression free survival (PFS) and overall survival (OS) in all the identified random control trials and in subgroups composed of younger/fit and older/unfit patients, using a Bayesian network meta-analysis. Results In younger/fit patients we obtained median of projected mean PFS of: 19, 26, 31, 43, 51 and 75 months for chlorambucil, fludarabine, alemtuzumab, fludarabine with cyclophosphamide (FC), bendamustine and fludarabine with cyclophosphamide and rituximab (FCR), respectively. We noted median OS of: 59, 66, 66, 70 months for FC, chlorambucil, FCR and fludarabine, respectively. In older/unfit patients we noted PFS of: 16, 17, 24, 30, 60 months for chlorambucil, fludarabine and chlorambucil with ofatumumab (OClb) or rituximab (RClb) or obinutuzumab (GClb), respectively. We obtained median OS of: 44, 58, 59 and 90 months for fludarabine, RClb, chlorambucil and GClb, respectively. Conclusions Our results suggest that: (1) FCR has higher potential of preventing CLL progression in younger/fit patients over four therapy options, which were subject of previous meta-analysis but also over bendamustine; (2) in these patients FCR does not entail prolonging of OS in comparison with chlorambucil and it is outperformed by fludarabine; (3) in older/unfit patients GClb demonstrates longer projected PFS than all assessed comparators; (4) in this group GClb has also the highest potential of increasing OS." @default.
• W2038107959 created "2016-06-24" @default.
• W2038107959 creator A5008533172 @default.
• W2038107959 creator A5032588943 @default.
• W2038107959 creator A5071408584 @default.
• W2038107959 date "2015-02-01" @default.
• W2038107959 modified "2023-09-27" @default.
• W2038107959 title "A network meta-analysis of progression free survival and overall survival in first-line treatment of chronic lymphocytic leukemia" @default.
• W2038107959 cites W142412262 @default.
• W2038107959 cites W1967008538 @default.
• W2038107959 cites W1967385770 @default.
• W2038107959 cites W1986215651 @default.
• W2038107959 cites W1995916528 @default.
• W2038107959 cites W1998954504 @default.
• W2038107959 cites W2000903996 @default.
• W2038107959 cites W2047982141 @default.
• W2038107959 cites W2057765075 @default.
• W2038107959 cites W2059573268 @default.
• W2038107959 cites W2078249396 @default.
• W2038107959 cites W2099145932 @default.
• W2038107959 cites W2116248495 @default.
• W2038107959 cites W2120319857 @default.
• W2038107959 cites W2134012062 @default.
• W2038107959 cites W2134057518 @default.
• W2038107959 cites W2135270635 @default.
• W2038107959 cites W2140606816 @default.
• W2038107959 cites W2140731037 @default.
• W2038107959 cites W2142099365 @default.
• W2038107959 cites W2144489990 @default.
• W2038107959 cites W2149147062 @default.
• W2038107959 cites W2163348695 @default.
• W2038107959 cites W2317888977 @default.
• W2038107959 cites W2323897083 @default.
• W2038107959 cites W2326175431 @default.
• W2038107959 cites W2335838520 @default.
• W2038107959 cites W4243082053 @default.
• W2038107959 cites W4376595664 @default.
• W2038107959 cites W8702881 @default.
• W2038107959 doi "https://doi.org/10.1016/j.ctrv.2014.11.004" @default.
• W2038107959 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25512118" @default.
• W2038107959 hasPublicationYear "2015" @default.
• W2038107959 type Work @default.
• W2038107959 sameAs 2038107959 @default.
• W2038107959 citedByCount "13" @default.
• W2038107959 countsByYear W20381079592015 @default.
• W2038107959 countsByYear W20381079592016 @default.
• W2038107959 countsByYear W20381079592017 @default.
• W2038107959 countsByYear W20381079592020 @default.
• W2038107959 countsByYear W20381079592021 @default.
• W2038107959 countsByYear W20381079592022 @default.
• W2038107959 countsByYear W20381079592023 @default.
• W2038107959 crossrefType "journal-article" @default.
• W2038107959 hasAuthorship W2038107959A5008533172 @default.
• W2038107959 hasAuthorship W2038107959A5032588943 @default.
• W2038107959 hasAuthorship W2038107959A5071408584 @default.
• W2038107959 hasConcept C126322002 @default.
• W2038107959 hasConcept C141071460 @default.
• W2038107959 hasConcept C143998085 @default.
• W2038107959 hasConcept C2776694085 @default.
• W2038107959 hasConcept C2776755627 @default.
• W2038107959 hasConcept C2777607594 @default.
• W2038107959 hasConcept C2777866208 @default.
• W2038107959 hasConcept C2777938653 @default.
• W2038107959 hasConcept C2778461978 @default.
• W2038107959 hasConcept C2778714382 @default.
• W2038107959 hasConcept C2779015954 @default.
• W2038107959 hasConcept C2779263901 @default.
• W2038107959 hasConcept C2779338263 @default.
• W2038107959 hasConcept C2780653079 @default.
• W2038107959 hasConcept C2780739268 @default.
• W2038107959 hasConcept C2780790343 @default.
• W2038107959 hasConcept C2781442060 @default.
• W2038107959 hasConcept C2911091166 @default.
• W2038107959 hasConcept C71924100 @default.
• W2038107959 hasConceptScore W2038107959C126322002 @default.
• W2038107959 hasConceptScore W2038107959C141071460 @default.
• W2038107959 hasConceptScore W2038107959C143998085 @default.
• W2038107959 hasConceptScore W2038107959C2776694085 @default.
• W2038107959 hasConceptScore W2038107959C2776755627 @default.
• W2038107959 hasConceptScore W2038107959C2777607594 @default.
• W2038107959 hasConceptScore W2038107959C2777866208 @default.
• W2038107959 hasConceptScore W2038107959C2777938653 @default.
• W2038107959 hasConceptScore W2038107959C2778461978 @default.
• W2038107959 hasConceptScore W2038107959C2778714382 @default.
• W2038107959 hasConceptScore W2038107959C2779015954 @default.
• W2038107959 hasConceptScore W2038107959C2779263901 @default.
• W2038107959 hasConceptScore W2038107959C2779338263 @default.
• W2038107959 hasConceptScore W2038107959C2780653079 @default.
• W2038107959 hasConceptScore W2038107959C2780739268 @default.
• W2038107959 hasConceptScore W2038107959C2780790343 @default.
• W2038107959 hasConceptScore W2038107959C2781442060 @default.
• W2038107959 hasConceptScore W2038107959C2911091166 @default.
• W2038107959 hasConceptScore W2038107959C71924100 @default.
• W2038107959 hasIssue "2" @default.
• W2038107959 hasLocation W20381079591 @default.
• W2038107959 hasLocation W20381079592 @default.
• W2038107959 hasOpenAccess W2038107959 @default.
• W2038107959 hasPrimaryLocation W20381079591 @default.

• next