Matches in SemOpenAlex for { <https://semopenalex.org/work/W2038137133> ?p ?o ?g. }
- W2038137133 endingPage "e1004946" @default.
- W2038137133 startingPage "e1004946" @default.
- W2038137133 abstract "Directional migration of neural crest (NC) cells is essential for patterning the vertebrate embryo, including the craniofacial skeleton. Extensive filopodial protrusions in NC cells are thought to sense chemo-attractive/repulsive signals that provide directionality. To test this hypothesis, we generated null mutations in zebrafish fascin1a (fscn1a), which encodes an actin-bundling protein required for filopodia formation. Homozygous fscn1a zygotic null mutants have normal NC filopodia due to unexpected stability of maternal Fscn1a protein throughout NC development and into juvenile stages. In contrast, maternal/zygotic fscn1a null mutant embryos (fscn1a MZ) have severe loss of NC filopodia. However, only a subset of NC streams display migration defects, associated with selective loss of craniofacial elements and peripheral neurons. We also show that fscn1a-dependent NC migration functions through cxcr4a/cxcl12b chemokine signaling to ensure the fidelity of directional cell migration. These data show that fscn1a-dependent filopodia are required in a subset of NC cells to promote cell migration and NC derivative formation, and that perdurance of long-lived maternal proteins can mask essential zygotic gene functions during NC development." @default.
- W2038137133 created "2016-06-24" @default.
- W2038137133 creator A5032617904 @default.
- W2038137133 creator A5033203315 @default.
- W2038137133 creator A5038705503 @default.
- W2038137133 creator A5046332802 @default.
- W2038137133 creator A5069401265 @default.
- W2038137133 date "2015-01-21" @default.
- W2038137133 modified "2023-10-17" @default.
- W2038137133 title "Fascin1-Dependent Filopodia are Required for Directional Migration of a Subset of Neural Crest Cells" @default.
- W2038137133 cites W1538706143 @default.
- W2038137133 cites W1565566882 @default.
- W2038137133 cites W160918071 @default.
- W2038137133 cites W1952870715 @default.
- W2038137133 cites W1965310536 @default.
- W2038137133 cites W1967661785 @default.
- W2038137133 cites W1971465061 @default.
- W2038137133 cites W1980824787 @default.
- W2038137133 cites W1984696056 @default.
- W2038137133 cites W1997168981 @default.
- W2038137133 cites W1998365428 @default.
- W2038137133 cites W2002466559 @default.
- W2038137133 cites W2003744362 @default.
- W2038137133 cites W2006292913 @default.
- W2038137133 cites W2011146811 @default.
- W2038137133 cites W2011963170 @default.
- W2038137133 cites W2014803841 @default.
- W2038137133 cites W2015499825 @default.
- W2038137133 cites W2015679500 @default.
- W2038137133 cites W2022777558 @default.
- W2038137133 cites W2022906661 @default.
- W2038137133 cites W2023024480 @default.
- W2038137133 cites W2024312058 @default.
- W2038137133 cites W2026260372 @default.
- W2038137133 cites W2028542401 @default.
- W2038137133 cites W2032756435 @default.
- W2038137133 cites W2035416365 @default.
- W2038137133 cites W2037095294 @default.
- W2038137133 cites W2038634187 @default.
- W2038137133 cites W2040228198 @default.
- W2038137133 cites W2045911477 @default.
- W2038137133 cites W2047043611 @default.
- W2038137133 cites W2056392247 @default.
- W2038137133 cites W2057887205 @default.
- W2038137133 cites W2063671952 @default.
- W2038137133 cites W2065358251 @default.
- W2038137133 cites W2066092773 @default.
- W2038137133 cites W2068166332 @default.
- W2038137133 cites W2073080330 @default.
- W2038137133 cites W2076221823 @default.
- W2038137133 cites W2077714658 @default.
- W2038137133 cites W2078801891 @default.
- W2038137133 cites W2087074988 @default.
- W2038137133 cites W2090164563 @default.
- W2038137133 cites W2099620922 @default.
- W2038137133 cites W2101361069 @default.
- W2038137133 cites W2106369370 @default.
- W2038137133 cites W2109649512 @default.
- W2038137133 cites W2114838239 @default.
- W2038137133 cites W2117199255 @default.
- W2038137133 cites W2118160713 @default.
- W2038137133 cites W2121588102 @default.
- W2038137133 cites W2123373545 @default.
- W2038137133 cites W2138028202 @default.
- W2038137133 cites W2138694826 @default.
- W2038137133 cites W2145025482 @default.
- W2038137133 cites W2154477609 @default.
- W2038137133 cites W2156993967 @default.
- W2038137133 cites W2158324692 @default.
- W2038137133 cites W2160370078 @default.
- W2038137133 cites W2161217765 @default.
- W2038137133 cites W2161954865 @default.
- W2038137133 cites W2163918659 @default.
- W2038137133 cites W2168245648 @default.
- W2038137133 cites W2171818093 @default.
- W2038137133 cites W2187401758 @default.
- W2038137133 cites W2330509585 @default.
- W2038137133 cites W2505801101 @default.
- W2038137133 doi "https://doi.org/10.1371/journal.pgen.1004946" @default.
- W2038137133 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4301650" @default.
- W2038137133 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25607881" @default.
- W2038137133 hasPublicationYear "2015" @default.
- W2038137133 type Work @default.
- W2038137133 sameAs 2038137133 @default.
- W2038137133 citedByCount "45" @default.
- W2038137133 countsByYear W20381371332015 @default.
- W2038137133 countsByYear W20381371332016 @default.
- W2038137133 countsByYear W20381371332017 @default.
- W2038137133 countsByYear W20381371332018 @default.
- W2038137133 countsByYear W20381371332019 @default.
- W2038137133 countsByYear W20381371332020 @default.
- W2038137133 countsByYear W20381371332021 @default.
- W2038137133 countsByYear W20381371332022 @default.
- W2038137133 countsByYear W20381371332023 @default.
- W2038137133 crossrefType "journal-article" @default.
- W2038137133 hasAuthorship W2038137133A5032617904 @default.
- W2038137133 hasAuthorship W2038137133A5033203315 @default.
- W2038137133 hasAuthorship W2038137133A5038705503 @default.