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- W2038142688 endingPage "1042" @default.
- W2038142688 startingPage "1042" @default.
- W2038142688 abstract "Since its initial description in 1964, research has transformed spontaneous bacterial peritonitis (SBP) from a feared disease (with reported mortality of 90%) to a treatable complication of decompensated cirrhosis, albeit with steady prevalence and a high recurrence rate. Bacterial translocation, the key mechanism in the pathogenesis of SBP, is only possible because of the concurrent failure of defensive mechanisms in cirrhosis. Variants of SBP should be treated. Leucocyte esterase reagent strips have managed to shorten the 'tap-to-shot' time, while future studies should look into their combined use with ascitic fluid pH. Third generation cephalosporins are the antibiotic of choice because they have a number of advantages. Renal dysfunction has been shown to be an independent predictor of mortality in patients with SBP. Albumin is felt to reduce the risk of renal impairment by improving effective intravascular volume, and by helping to bind pro-inflammatory molecules. Following a single episode of SBP, patients should have long-term antibiotic prophylaxis and be considered for liver transplantation." @default.
- W2038142688 created "2016-06-24" @default.
- W2038142688 creator A5036306772 @default.
- W2038142688 creator A5072299664 @default.
- W2038142688 creator A5077473596 @default.
- W2038142688 date "2009-01-01" @default.
- W2038142688 modified "2023-09-25" @default.
- W2038142688 title "Spontaneous bacterial peritonitis" @default.
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- W2038142688 doi "https://doi.org/10.3748/wjg.15.1042" @default.
- W2038142688 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2655193" @default.
- W2038142688 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19266595" @default.