FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2038148520> ?p ?o ?g. }

• W2038148520 endingPage "314" @default.
• W2038148520 startingPage "306" @default.
• W2038148520 abstract "Chronic graft-versus-host disease (cGVHD) is an increasingly frequent complication of allogeneic stem cell transplantation. We previously showed that anti-CD137 monoclonal antibody (mAb) can cure advanced cGVHD by inducing activation-induced cell death of donor T cells. In this study, we examined whether administration of anti-CD137 mAb can prevent the development of cGVHD after bone marrow transplantation (BMT) in mice conditioned with total body irradiation (TBI). We used the B10.D2→Balb/c (H-2d) minor histocompatibility antigen-mismatched model, which reflects clinical and pathological symptoms of human cGVHD. A single injection of anti-CD137 mAb was administered immediately after BMT. In contrast to the results obtained from the curing model of cGVHD, anti-CD137 given simultaneously with BMT resulted in lethal GVHD. Histopathologic evaluation revealed inflammation and damage of target organs from acute GVHD (aGVHD) in anti-CD137-treated mice. Anti-CD137–induced lethal aGVHD required host cells, as well as irradiation and mature donor T cells. Apparently, anti-CD137 mAb rapidly induced activation of donor T cells and sustained their activation status under the inflammatory condition triggered by irradiation. When given on day 12 after irradiation and BMT, anti-CD137 mAb could still exacerbate GVHD, but when given on day 30, it could not. Our data demonstrate that anti-CD137 mAb can amplify inflammation induced by host preconditioning, subsequently resulting in lethal aGVHD; thus, alleviating irradiation-induced toxicity is critical to allow the use of anti-CD137 mAb as GVHD prophylaxis." @default.
• W2038148520 created "2016-06-24" @default.
• W2038148520 creator A5003346789 @default.
• W2038148520 creator A5010288097 @default.
• W2038148520 creator A5038960389 @default.
• W2038148520 creator A5039646092 @default.
• W2038148520 creator A5047339275 @default.
• W2038148520 creator A5054866052 @default.
• W2038148520 creator A5091701566 @default.
• W2038148520 date "2009-03-01" @default.
• W2038148520 modified "2023-10-16" @default.
• W2038148520 title "Induction of Lethal Graft-versus-Host Disease by Anti-CD137 Monoclonal Antibody in Mice Prone to Chronic Graft-versus-Host Disease" @default.
• W2038148520 cites W1480177881 @default.
• W2038148520 cites W1482617484 @default.
• W2038148520 cites W1490032473 @default.
• W2038148520 cites W1492642877 @default.
• W2038148520 cites W1527192303 @default.
• W2038148520 cites W1532420525 @default.
• W2038148520 cites W1556461127 @default.
• W2038148520 cites W1595196077 @default.
• W2038148520 cites W1795844187 @default.
• W2038148520 cites W1819878754 @default.
• W2038148520 cites W1962111487 @default.
• W2038148520 cites W1966163786 @default.
• W2038148520 cites W1978982771 @default.
• W2038148520 cites W1985988830 @default.
• W2038148520 cites W1988718803 @default.
• W2038148520 cites W2000900408 @default.
• W2038148520 cites W2005630249 @default.
• W2038148520 cites W2020387130 @default.
• W2038148520 cites W2025447211 @default.
• W2038148520 cites W2036872637 @default.
• W2038148520 cites W2041027155 @default.
• W2038148520 cites W2041102443 @default.
• W2038148520 cites W2044166736 @default.
• W2038148520 cites W2045235581 @default.
• W2038148520 cites W2047665149 @default.
• W2038148520 cites W2048973279 @default.
• W2038148520 cites W2049794122 @default.
• W2038148520 cites W2054230177 @default.
• W2038148520 cites W2056453604 @default.
• W2038148520 cites W2063491568 @default.
• W2038148520 cites W2075840867 @default.
• W2038148520 cites W2076623839 @default.
• W2038148520 cites W2082173810 @default.
• W2038148520 cites W2084224223 @default.
• W2038148520 cites W2099241614 @default.
• W2038148520 cites W2119624288 @default.
• W2038148520 cites W2123189570 @default.
• W2038148520 cites W2132486642 @default.
• W2038148520 cites W2134779076 @default.
• W2038148520 cites W2135336115 @default.
• W2038148520 cites W2159536303 @default.
• W2038148520 cites W2167153348 @default.
• W2038148520 cites W2170758122 @default.
• W2038148520 cites W2398419231 @default.
• W2038148520 cites W2414969937 @default.
• W2038148520 cites W4241646216 @default.
• W2038148520 cites W4313347678 @default.
• W2038148520 doi "https://doi.org/10.1016/j.bbmt.2008.11.035" @default.
• W2038148520 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19203721" @default.
• W2038148520 hasPublicationYear "2009" @default.
• W2038148520 type Work @default.
• W2038148520 sameAs 2038148520 @default.
• W2038148520 citedByCount "19" @default.
• W2038148520 countsByYear W20381485202012 @default.
• W2038148520 countsByYear W20381485202013 @default.
• W2038148520 countsByYear W20381485202014 @default.
• W2038148520 countsByYear W20381485202015 @default.
• W2038148520 countsByYear W20381485202017 @default.
• W2038148520 countsByYear W20381485202019 @default.
• W2038148520 countsByYear W20381485202020 @default.
• W2038148520 countsByYear W20381485202023 @default.
• W2038148520 crossrefType "journal-article" @default.
• W2038148520 hasAuthorship W2038148520A5003346789 @default.
• W2038148520 hasAuthorship W2038148520A5010288097 @default.
• W2038148520 hasAuthorship W2038148520A5038960389 @default.
• W2038148520 hasAuthorship W2038148520A5039646092 @default.
• W2038148520 hasAuthorship W2038148520A5047339275 @default.
• W2038148520 hasAuthorship W2038148520A5054866052 @default.
• W2038148520 hasAuthorship W2038148520A5091701566 @default.
• W2038148520 hasBestOaLocation W20381485201 @default.
• W2038148520 hasConcept C126322002 @default.
• W2038148520 hasConcept C159654299 @default.
• W2038148520 hasConcept C203014093 @default.
• W2038148520 hasConcept C2776914184 @default.
• W2038148520 hasConcept C2779972918 @default.
• W2038148520 hasConcept C2780249625 @default.
• W2038148520 hasConcept C2911091166 @default.
• W2038148520 hasConcept C542903549 @default.
• W2038148520 hasConcept C71924100 @default.
• W2038148520 hasConceptScore W2038148520C126322002 @default.
• W2038148520 hasConceptScore W2038148520C159654299 @default.
• W2038148520 hasConceptScore W2038148520C203014093 @default.
• W2038148520 hasConceptScore W2038148520C2776914184 @default.
• W2038148520 hasConceptScore W2038148520C2779972918 @default.
• W2038148520 hasConceptScore W2038148520C2780249625 @default.
• W2038148520 hasConceptScore W2038148520C2911091166 @default.

• next