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- W2038150597 abstract "Lymphocytes from mice of strain CBA are strongly MLC-responsive to lymphocytes from the H-2 compatible- but M-antigen-incompatible strain C3H. This strong reactivity disappears after infusion of CBA mice with C3H lymphocytes. This study shows that the host-versus-graft reactivity (swelling of local lymph node after antigen injection) is specifically reduced after injection of CBA mice with C3H × CBA spleen cells However, lymphocytes from such mice showed a specifically increased GVH reactivity (inhibition of erythroid cell growth) compared with lymphocytes from unimmunized mice. Lymphocytes from normal CBA mice showed a high proliferative rate in the spleens of irradiated C3H × CBA mice. Such ‘educated’ cells showed strongly increased specific GVH reactivity. Lymphocytes from CBA mice previously injected with C3H×CBA cells showed reduced capacity to proliferate when injected into irradiated C3H × CBA hybrids and a poor capacity to develop new ‘effector’ cells reactive against C3H × CBA bone marrow target cells. The results indicate that the presence of specifically ‘MLC responsive’ lymphocytes in a lymphoid cell population is a prerequisite of its production of ‘effector’ cells able to respond in this GVH assay" @default.
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- W2038150597 date "1975-07-01" @default.
- W2038150597 modified "2023-10-18" @default.
- W2038150597 title "Reduced Capacity to Produce Specific 'Effector' Cells after Injection of CBA Mice with C3H Cells" @default.
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- W2038150597 doi "https://doi.org/10.1111/j.1365-3083.1975.tb02651.x" @default.
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