FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2038153181> ?p ?o ?g. }

• W2038153181 endingPage "3390" @default.
• W2038153181 startingPage "3383" @default.
• W2038153181 abstract "Androgens, like estrogens, have been linked to neuroprotective effects in the brain and to the improvement of cognitive function. Part of this effect may be due to the action of androgens on the innate immune response. We have examined the action of dihydrotestosterone (DHT) and testosterone on immune activation in primary cultures of microglia, the central nervous system macrophage. Our data indicate that DHT acts as an antiinflammatory agent and depresses both nitric oxide and TNFα production in a dose-dependent fashion. However, testosterone treatment of microglia and peritoneal macrophages increased supernatant nitrite levels, indicative of a proinflammatory effect. Because the apolipoprotein E (APOE) genotype also dramatically impacts macrophage function and has been linked to neurodegenerative disease, we compared the effects of APOE genotype on androgen-mediated regulation of inflammation using targeted replacement mice expressing only the human APOE3 or human APOE4 gene. Our data show that the antiinflammatory activity of DHT is significantly reduced in APOE4 targeted replacement mice compared to APOE3 mice. The effect was not due to an APOE isoform-specific change in androgen receptor mRNA and protein expression. Rather, innate immune signaling pathways regulated by androgens are altered in the APOE4 microglia. Compared to APOE3 microglia, DHT treatment did not reduce the phosphorylation of p38 MAPK or p54/p56 Janus kinase in APOE4 mice. Thus, our data suggest that DHT modulation of kinase activity is altered in microglia from mice expressing an APOE4 genotype and may impact androgen treatment therapies in individuals with an APOE4 genotype." @default.
• W2038153181 created "2016-06-24" @default.
• W2038153181 creator A5000594249 @default.
• W2038153181 creator A5000733461 @default.
• W2038153181 creator A5002100940 @default.
• W2038153181 creator A5023363916 @default.
• W2038153181 creator A5026615375 @default.
• W2038153181 date "2007-07-01" @default.
• W2038153181 modified "2023-10-16" @default.
• W2038153181 title "Androgen-Mediated Immune Function Is Altered by the Apolipoprotein E Gene" @default.
• W2038153181 cites W1215373674 @default.
• W2038153181 cites W1486663554 @default.
• W2038153181 cites W1487581481 @default.
• W2038153181 cites W1495448998 @default.
• W2038153181 cites W1500145074 @default.
• W2038153181 cites W1563459863 @default.
• W2038153181 cites W1586271676 @default.
• W2038153181 cites W1965085193 @default.
• W2038153181 cites W1970601481 @default.
• W2038153181 cites W1971386010 @default.
• W2038153181 cites W1971736309 @default.
• W2038153181 cites W1972368286 @default.
• W2038153181 cites W1975880549 @default.
• W2038153181 cites W1976358248 @default.
• W2038153181 cites W1979096652 @default.
• W2038153181 cites W1979485513 @default.
• W2038153181 cites W1981129287 @default.
• W2038153181 cites W1989736409 @default.
• W2038153181 cites W1989990363 @default.
• W2038153181 cites W1991158043 @default.
• W2038153181 cites W1991882458 @default.
• W2038153181 cites W1998086294 @default.
• W2038153181 cites W1998152179 @default.
• W2038153181 cites W2005574634 @default.
• W2038153181 cites W2009182898 @default.
• W2038153181 cites W2015005466 @default.
• W2038153181 cites W2017968372 @default.
• W2038153181 cites W2027586930 @default.
• W2038153181 cites W2027639859 @default.
• W2038153181 cites W2032490010 @default.
• W2038153181 cites W2034175214 @default.
• W2038153181 cites W2036662131 @default.
• W2038153181 cites W2039406268 @default.
• W2038153181 cites W2043348076 @default.
• W2038153181 cites W2045317765 @default.
• W2038153181 cites W2045645123 @default.
• W2038153181 cites W2047985468 @default.
• W2038153181 cites W2051596822 @default.
• W2038153181 cites W2052986007 @default.
• W2038153181 cites W2053706832 @default.
• W2038153181 cites W2058120050 @default.
• W2038153181 cites W2058799638 @default.
• W2038153181 cites W2059865238 @default.
• W2038153181 cites W2067421930 @default.
• W2038153181 cites W2073729932 @default.
• W2038153181 cites W2075568717 @default.
• W2038153181 cites W2077647993 @default.
• W2038153181 cites W2083495321 @default.
• W2038153181 cites W2083517169 @default.
• W2038153181 cites W2088262401 @default.
• W2038153181 cites W2094904916 @default.
• W2038153181 cites W2105803743 @default.
• W2038153181 cites W2107277218 @default.
• W2038153181 cites W2109342780 @default.
• W2038153181 cites W2124245112 @default.
• W2038153181 cites W2127680781 @default.
• W2038153181 cites W2128175744 @default.
• W2038153181 cites W2154865730 @default.
• W2038153181 cites W2166555377 @default.
• W2038153181 cites W2167017590 @default.
• W2038153181 cites W2167182730 @default.
• W2038153181 cites W2183251509 @default.
• W2038153181 cites W2125461486 @default.
• W2038153181 doi "https://doi.org/10.1210/en.2006-1200" @default.
• W2038153181 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17395708" @default.
• W2038153181 hasPublicationYear "2007" @default.
• W2038153181 type Work @default.
• W2038153181 sameAs 2038153181 @default.
• W2038153181 citedByCount "34" @default.
• W2038153181 countsByYear W20381531812013 @default.
• W2038153181 countsByYear W20381531812014 @default.
• W2038153181 countsByYear W20381531812015 @default.
• W2038153181 countsByYear W20381531812016 @default.
• W2038153181 countsByYear W20381531812017 @default.
• W2038153181 countsByYear W20381531812018 @default.
• W2038153181 countsByYear W20381531812020 @default.
• W2038153181 countsByYear W20381531812021 @default.
• W2038153181 countsByYear W20381531812022 @default.
• W2038153181 crossrefType "journal-article" @default.
• W2038153181 hasAuthorship W2038153181A5000594249 @default.
• W2038153181 hasAuthorship W2038153181A5000733461 @default.
• W2038153181 hasAuthorship W2038153181A5002100940 @default.
• W2038153181 hasAuthorship W2038153181A5023363916 @default.
• W2038153181 hasAuthorship W2038153181A5026615375 @default.
• W2038153181 hasBestOaLocation W20381531811 @default.
• W2038153181 hasConcept C121608353 @default.
• W2038153181 hasConcept C126322002 @default.
• W2038153181 hasConcept C134018914 @default.

• next