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• W2038166908 abstract "It has been well documented that 1,25(OH)2D3 regulates the synthesis of collagen, however, little is known about its effect on the quality of collagen. Most recently, we have demonstrated that 1,25(OH)2D3 upregulates the expression of specific isoforms of lysyl hydroxylases (LHs) and lysyl oxidases (LOXs) in murine osteoblastic cell line, MC3T3-E1 cells resulting in specific collagen cross-linking pattern (1). However, at present, it is not clear whether or not this is a generalized effect or cell type specific. In order to address this, we investigated the effects of 1,25(OH)2D3 on gene expression of LHs and LOXs and the extent of lysine (Lys) hydroxylation of collagen using an fibroblastic cell line, NIH3T3 cells. The effect was compared to controls where cells were treated with cholecalciferol (VD3) or ethanol (Et-OH). When compared to the controls, gene expressions of LH1 and LH2 were upregulated and LOXL2 was markedly upregulated by 1,25(OH)2D3 at 48 hours of culture. The extent of Lys hydroxylation of collagen was only slightly higher in the 1,25(OH)2D3 treated group. This study indicates that 1,25(OH)2D3 regulates the expression of collagen modifying enzymes in fibroblastic cells in a similar manner as osteoblastic cells but the extent of the effects could vary depending on the cell types." @default.
• W2038166908 created "2016-06-24" @default.
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• W2038166908 date "2009-01-01" @default.
• W2038166908 modified "2023-10-03" @default.
• W2038166908 title "Effect of 1,25(OH)2D3 on Collagen Post-Translational Modifications in a Fibroblastic Cell Culture System" @default.
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• W2038166908 doi "https://doi.org/10.5466/ijoms.8.32" @default.
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