Matches in SemOpenAlex for { <https://semopenalex.org/work/W2038172542> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2038172542 endingPage "875" @default.
- W2038172542 startingPage "870" @default.
- W2038172542 abstract "To explore the utility of intravenous (i.v.) prourokinase treatment, we compared intra-arterial (i.a.) and i.v. delivery in a rat embolic stroke model, using diffusion (DWI) and perfusion (PI) magnetic resonance imaging to assess in vivo effects on ischemic lesion evolution and reperfusion.Thrombolytic therapy with recombinant tissue-type plasminogen activator (rt-PA) for acute ischemic stroke is useful during the initial hours after onset. Prourokinase is a novel thrombolytic agent with potential safety advantages in comparison to rt-PA.Twenty-four male Sprague-Dawley rats were embolized with autologous blood clots into the middle cerebral artery territory and then randomly assigned at 30 minutes after embolization to a 2-hour bolus infusion with i.a. prourokinase, i.v. prourokinase, or vehicle. DWI and PI were performed before treatment and repeated during and at the end of the treatment.PI demonstrated that both i.a. and i.v. significantly improved the percentage of the ischemic hemisphere that was normally perfused when the 20-minute, pretreatment, and 145-minute after embolization time points were compared; in the control group, the hypoperfused volume increased over time. DWI disclosed that the ischemic lesion evolution slightly decreased in the i.a. group, remained stable in the i.v. group, and increased over time in the control group. Infarct volume by triphenyltetrazolium chloride (TTC) staining was significantly smaller in both treatment groups than controls.These results demonstrate that i.a. and i.v. therapy with prourokinase are equally effective in promoting reperfusion and inhibiting the development of focal ischemic injury in this rat embolic stroke model." @default.
- W2038172542 created "2016-06-24" @default.
- W2038172542 creator A5035909731 @default.
- W2038172542 creator A5036747513 @default.
- W2038172542 creator A5039568112 @default.
- W2038172542 creator A5052093387 @default.
- W2038172542 creator A5062841169 @default.
- W2038172542 creator A5072837575 @default.
- W2038172542 creator A5085144463 @default.
- W2038172542 date "1998-04-01" @default.
- W2038172542 modified "2023-09-25" @default.
- W2038172542 title "Efficacy of intra-arterial and intravenous prourokinase in an embolic stroke model evaluated by diffusion-perfusion magnetic resonance imaging" @default.
- W2038172542 cites W1990859472 @default.
- W2038172542 cites W2055876104 @default.
- W2038172542 cites W2110999346 @default.
- W2038172542 cites W2134381162 @default.
- W2038172542 cites W2326335154 @default.
- W2038172542 doi "https://doi.org/10.1212/wnl.50.4.870" @default.
- W2038172542 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9566365" @default.
- W2038172542 hasPublicationYear "1998" @default.
- W2038172542 type Work @default.
- W2038172542 sameAs 2038172542 @default.
- W2038172542 citedByCount "51" @default.
- W2038172542 countsByYear W20381725422014 @default.
- W2038172542 countsByYear W20381725422015 @default.
- W2038172542 countsByYear W20381725422017 @default.
- W2038172542 countsByYear W20381725422021 @default.
- W2038172542 countsByYear W20381725422022 @default.
- W2038172542 crossrefType "journal-article" @default.
- W2038172542 hasAuthorship W2038172542A5035909731 @default.
- W2038172542 hasAuthorship W2038172542A5036747513 @default.
- W2038172542 hasAuthorship W2038172542A5039568112 @default.
- W2038172542 hasAuthorship W2038172542A5052093387 @default.
- W2038172542 hasAuthorship W2038172542A5062841169 @default.
- W2038172542 hasAuthorship W2038172542A5072837575 @default.
- W2038172542 hasAuthorship W2038172542A5085144463 @default.
- W2038172542 hasConcept C126322002 @default.
- W2038172542 hasConcept C126838900 @default.
- W2038172542 hasConcept C127413603 @default.
- W2038172542 hasConcept C141071460 @default.
- W2038172542 hasConcept C143409427 @default.
- W2038172542 hasConcept C146957229 @default.
- W2038172542 hasConcept C149550507 @default.
- W2038172542 hasConcept C2775841333 @default.
- W2038172542 hasConcept C2776035437 @default.
- W2038172542 hasConcept C2776572282 @default.
- W2038172542 hasConcept C2778820722 @default.
- W2038172542 hasConcept C2780645631 @default.
- W2038172542 hasConcept C2781156865 @default.
- W2038172542 hasConcept C2989005 @default.
- W2038172542 hasConcept C3020199598 @default.
- W2038172542 hasConcept C42219234 @default.
- W2038172542 hasConcept C43376680 @default.
- W2038172542 hasConcept C541997718 @default.
- W2038172542 hasConcept C71924100 @default.
- W2038172542 hasConcept C78519656 @default.
- W2038172542 hasConceptScore W2038172542C126322002 @default.
- W2038172542 hasConceptScore W2038172542C126838900 @default.
- W2038172542 hasConceptScore W2038172542C127413603 @default.
- W2038172542 hasConceptScore W2038172542C141071460 @default.
- W2038172542 hasConceptScore W2038172542C143409427 @default.
- W2038172542 hasConceptScore W2038172542C146957229 @default.
- W2038172542 hasConceptScore W2038172542C149550507 @default.
- W2038172542 hasConceptScore W2038172542C2775841333 @default.
- W2038172542 hasConceptScore W2038172542C2776035437 @default.
- W2038172542 hasConceptScore W2038172542C2776572282 @default.
- W2038172542 hasConceptScore W2038172542C2778820722 @default.
- W2038172542 hasConceptScore W2038172542C2780645631 @default.
- W2038172542 hasConceptScore W2038172542C2781156865 @default.
- W2038172542 hasConceptScore W2038172542C2989005 @default.
- W2038172542 hasConceptScore W2038172542C3020199598 @default.
- W2038172542 hasConceptScore W2038172542C42219234 @default.
- W2038172542 hasConceptScore W2038172542C43376680 @default.
- W2038172542 hasConceptScore W2038172542C541997718 @default.
- W2038172542 hasConceptScore W2038172542C71924100 @default.
- W2038172542 hasConceptScore W2038172542C78519656 @default.
- W2038172542 hasIssue "4" @default.
- W2038172542 hasLocation W20381725421 @default.
- W2038172542 hasLocation W20381725422 @default.
- W2038172542 hasOpenAccess W2038172542 @default.
- W2038172542 hasPrimaryLocation W20381725421 @default.
- W2038172542 hasRelatedWork W1490442457 @default.
- W2038172542 hasRelatedWork W1976006050 @default.
- W2038172542 hasRelatedWork W1988169277 @default.
- W2038172542 hasRelatedWork W2017714102 @default.
- W2038172542 hasRelatedWork W2059657934 @default.
- W2038172542 hasRelatedWork W2090680978 @default.
- W2038172542 hasRelatedWork W2157204203 @default.
- W2038172542 hasRelatedWork W2166920969 @default.
- W2038172542 hasRelatedWork W2184279864 @default.
- W2038172542 hasRelatedWork W2162183922 @default.
- W2038172542 hasVolume "50" @default.
- W2038172542 isParatext "false" @default.
- W2038172542 isRetracted "false" @default.
- W2038172542 magId "2038172542" @default.
- W2038172542 workType "article" @default.