FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2038181873> ?p ?o ?g. }

• W2038181873 endingPage "527" @default.
• W2038181873 startingPage "517" @default.
• W2038181873 abstract "Antibodies to muscle-specific proteins were used in immunofluorescence to monitor the development of skeletal muscle during mouse embryogenesis. At gestation day (g.d.) 9 a single layer of vimentin filament containing cells in the myotome domain of cervical somites begins to stain positively for myogenic proteins. The muscle-specific proteins are expressed in a specific order between g.d. 9 and 9.5. Desmin is detected first, then titin, then the muscle specific actin and myosin heavy chains, and finally nebulin. At g.d. 9.5 fibrous desmin structures are already present, while for the other myogenic proteins no structure can be detected. Some prefusion myoblasts display at g.d. 11 and 12 tiny and immature myofibrils. These reveal a periodic pattern of myosin, nebulin, and those titin epitopes known to occur at and close to the Z line. In contrast titin epitopes, which are present in mature myofibrils along the A band and at the A-I junction, are still randomly distributed. We propose, that the Z line connected structures and the A bands (myosin filaments) assemble independently, and that the known interaction of the I-Z-I brushes with the A bands occurs at a later developmental stage. After fusion of myoblasts to myotubes at g.d. 13 and 14 all titin epitopes show the myofibrillar banding pattern. The predominantly longitudinal orientation of desmin filaments seen in myoblasts and in early myotubes is transformed at g.d. 17 and 18 to distinct Z line connected striations. Vimentin, still present together with desmin in the myoblasts, is lost from the myotubes. Our results indicate that the putative elastic titin filaments act as integrators during skeletal muscle development. Some developmental aspects of eye and limb muscles are also described." @default.
• W2038181873 created "2016-06-24" @default.
• W2038181873 creator A5052210547 @default.
• W2038181873 creator A5083618930 @default.
• W2038181873 creator A5087499408 @default.
• W2038181873 date "1989-08-01" @default.
• W2038181873 modified "2023-10-16" @default.
• W2038181873 title "Myogenesis in the mouse embryo: differential onset of expression of myogenic proteins and the involvement of titin in myofibril assembly." @default.
• W2038181873 cites W1266384774 @default.
• W2038181873 cites W1469270584 @default.
• W2038181873 cites W1504890289 @default.
• W2038181873 cites W1581322996 @default.
• W2038181873 cites W1968380946 @default.
• W2038181873 cites W1982726291 @default.
• W2038181873 cites W1985831209 @default.
• W2038181873 cites W1993693200 @default.
• W2038181873 cites W2016716219 @default.
• W2038181873 cites W2020819723 @default.
• W2038181873 cites W2028465506 @default.
• W2038181873 cites W2036291935 @default.
• W2038181873 cites W2036571146 @default.
• W2038181873 cites W2042249618 @default.
• W2038181873 cites W2042718107 @default.
• W2038181873 cites W2058835187 @default.
• W2038181873 cites W2070388090 @default.
• W2038181873 cites W2072221214 @default.
• W2038181873 cites W2074183712 @default.
• W2038181873 cites W2075325773 @default.
• W2038181873 cites W2078689467 @default.
• W2038181873 cites W2107385913 @default.
• W2038181873 cites W2108210376 @default.
• W2038181873 cites W2118202513 @default.
• W2038181873 cites W2121166557 @default.
• W2038181873 cites W2123705825 @default.
• W2038181873 cites W2145897147 @default.
• W2038181873 cites W2152351059 @default.
• W2038181873 cites W2153339926 @default.
• W2038181873 cites W2159814562 @default.
• W2038181873 cites W2161366283 @default.
• W2038181873 cites W2161528301 @default.
• W2038181873 cites W2170478592 @default.
• W2038181873 cites W2400076052 @default.
• W2038181873 cites W4236497821 @default.
• W2038181873 doi "https://doi.org/10.1083/jcb.109.2.517" @default.
• W2038181873 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2115733" @default.
• W2038181873 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2474551" @default.
• W2038181873 hasPublicationYear "1989" @default.
• W2038181873 type Work @default.
• W2038181873 sameAs 2038181873 @default.
• W2038181873 citedByCount "288" @default.
• W2038181873 countsByYear W20381818732012 @default.
• W2038181873 countsByYear W20381818732013 @default.
• W2038181873 countsByYear W20381818732014 @default.
• W2038181873 countsByYear W20381818732015 @default.
• W2038181873 countsByYear W20381818732016 @default.
• W2038181873 countsByYear W20381818732017 @default.
• W2038181873 countsByYear W20381818732018 @default.
• W2038181873 countsByYear W20381818732019 @default.
• W2038181873 countsByYear W20381818732020 @default.
• W2038181873 countsByYear W20381818732021 @default.
• W2038181873 countsByYear W20381818732023 @default.
• W2038181873 crossrefType "journal-article" @default.
• W2038181873 hasAuthorship W2038181873A5052210547 @default.
• W2038181873 hasAuthorship W2038181873A5083618930 @default.
• W2038181873 hasAuthorship W2038181873A5087499408 @default.
• W2038181873 hasBestOaLocation W20381818731 @default.
• W2038181873 hasConcept C125705527 @default.
• W2038181873 hasConcept C142669718 @default.
• W2038181873 hasConcept C147447768 @default.
• W2038181873 hasConcept C1491633281 @default.
• W2038181873 hasConcept C153911025 @default.
• W2038181873 hasConcept C203014093 @default.
• W2038181873 hasConcept C204232928 @default.
• W2038181873 hasConcept C207200792 @default.
• W2038181873 hasConcept C2779072444 @default.
• W2038181873 hasConcept C2909370275 @default.
• W2038181873 hasConcept C37140074 @default.
• W2038181873 hasConcept C3763915 @default.
• W2038181873 hasConcept C55493867 @default.
• W2038181873 hasConcept C68731436 @default.
• W2038181873 hasConcept C6997183 @default.
• W2038181873 hasConcept C7301908 @default.
• W2038181873 hasConcept C78383274 @default.
• W2038181873 hasConcept C83323008 @default.
• W2038181873 hasConcept C86803240 @default.
• W2038181873 hasConcept C90671521 @default.
• W2038181873 hasConcept C95444343 @default.
• W2038181873 hasConceptScore W2038181873C125705527 @default.
• W2038181873 hasConceptScore W2038181873C142669718 @default.
• W2038181873 hasConceptScore W2038181873C147447768 @default.
• W2038181873 hasConceptScore W2038181873C1491633281 @default.
• W2038181873 hasConceptScore W2038181873C153911025 @default.
• W2038181873 hasConceptScore W2038181873C203014093 @default.
• W2038181873 hasConceptScore W2038181873C204232928 @default.
• W2038181873 hasConceptScore W2038181873C207200792 @default.
• W2038181873 hasConceptScore W2038181873C2779072444 @default.
• W2038181873 hasConceptScore W2038181873C2909370275 @default.
• W2038181873 hasConceptScore W2038181873C37140074 @default.

• next