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• W2038202357 abstract "This editorial refers to ‘A novel chimeric natriuretic peptide reduces cardiomyocyte hypertrophy through the NHE-1–calcineurin pathway’ by A. Kilic et al. , doi:10.1093/cvr/cvq254. As is well known, intravenously infused nesiritide [a recombinant form of brain-type natriuretic peptide (BNP)] antagonizes renin–angiotensin–aldosterone system activation and induces natriuresis, diuresis, and venous and arterial dilation. When administered to patients with acutely decompensated heart failure, a rapid reduction of pulmonary capillary pressure and consequent relief of dyspnoea often results. However, BNP-induced dilation of resistance (arterioles) and capacitance (veins) vessels taken together with the diuresis-associated reduction of blood (plasma) volume causes clinically significant systemic hypotension in some patients. Unfortunately, this hypotension can be associated with decreased renal perfusion and worsening of renal function, and the latter has been associated with increased morbidity and mortality in some clinical trials.1 The hypotension and consequent complications can be attenuated by reducing the dose of nesiritide being administered.1Recently, Burnett and colleagues speculated that they might be able to improve the therapeutic properties of natriuretic peptides by modifying their structures. Their goal was to generate a natriuretic peptide that retained the biological activities of BNP sans the capacity to dilate resistance vessels. Their first engineered chimeric natriuretic peptide (CD-NP) comprised the 15-amino acid C-terminus of the Dendroaspis peptide (a snake-derived natriuretic peptide) and the peptide ring component of the cardiac-type natriuretic peptide (CNP). CNP lacks renal actions but retains veno-dilator capacity and has only modest dilatory effects … *Corresponding author. Tel: +1 612 626 2001; fax: +1 612 626 2004, Email: fromx001{at}umn.edu" @default.
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• W2038202357 date "2010-10-08" @default.
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• W2038202357 title "Do engineered natriuretic peptides have greater therapeutic potential than do native peptides?" @default.
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• W2038202357 doi "https://doi.org/10.1093/cvr/cvq319" @default.
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