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- W2038204022 endingPage "71" @default.
- W2038204022 startingPage "59" @default.
- W2038204022 abstract "Summary: Immune homeostasis is regulated by a finely tuned network of positive–negative regulatory mechanisms that guarantees proper surveillance avoiding hyperactivity that would lead to autoimmunity and inflammatory diseases. Immune responses involve the activation of immunoreceptors that contain tyrosine‐based activation motifs (ITAMs). One arm of control involves immunoreceptor tyrosine‐based inhibitory motif (ITIM)‐bearing receptors, which upon co‐aggregation initiate an inhibitory signal through recruitment of signal‐aborting phosphatases. Recently, a new immunoregulatory function has been ascribed to ITAMs, which represent in fact dual function modules that, under specific configurations termed inhibitory ITAM (ITAMi), can propagate inhibitory signals. One paradigm is the immunoglobulin A (IgA) Fc receptor (FcαRI), which, upon interaction with IgA monomers in the absence of antigen, initiates a powerful inhibitory signal involving Src homology 2 domain‐containing phosphatase 1 (SHP‐1) recruitment that suppresses cell activation launched by a whole variety of heterologous receptors without co‐aggregation. This explains the long known function of IgA as an anti‐inflammatory isotype. The importance of this control mechanism in immune homeostasis is underlined by the high incidence of autoimmune and allergic diseases in IgA‐deficient patients. ITAMi is now described for an increasing number of immunoreceptors with multiple roles in immunity. ITAMi signaling is also exploited by Escherichia coli to achieve immune evasion during sepsis. Here, we review our current understanding of ITAMi regulatory mechanisms in immune responses and discuss its role in immune homeostasis." @default.
- W2038204022 created "2016-06-24" @default.
- W2038204022 creator A5025993462 @default.
- W2038204022 creator A5047064640 @default.
- W2038204022 creator A5060095793 @default.
- W2038204022 creator A5083238922 @default.
- W2038204022 date "2009-10-23" @default.
- W2038204022 modified "2023-10-04" @default.
- W2038204022 title "Inhibitory ITAMs as novel regulators of immunity" @default.
- W2038204022 cites W1494826373 @default.
- W2038204022 cites W1500421749 @default.
- W2038204022 cites W1544832651 @default.
- W2038204022 cites W1670121061 @default.
- W2038204022 cites W173263281 @default.
- W2038204022 cites W1755849265 @default.
- W2038204022 cites W1840824980 @default.
- W2038204022 cites W1895482825 @default.
- W2038204022 cites W1953360062 @default.
- W2038204022 cites W1964180982 @default.
- W2038204022 cites W1964726442 @default.
- W2038204022 cites W1964838986 @default.
- W2038204022 cites W1971692004 @default.
- W2038204022 cites W1972178991 @default.
- W2038204022 cites W1973792501 @default.
- W2038204022 cites W1978071531 @default.
- W2038204022 cites W1979820418 @default.
- W2038204022 cites W1980547319 @default.
- W2038204022 cites W1980754944 @default.
- W2038204022 cites W1981526021 @default.
- W2038204022 cites W1985240611 @default.
- W2038204022 cites W1985743621 @default.
- W2038204022 cites W1985748428 @default.
- W2038204022 cites W1993546845 @default.
- W2038204022 cites W1994553156 @default.
- W2038204022 cites W1995975339 @default.
- W2038204022 cites W1996058409 @default.
- W2038204022 cites W2004644593 @default.
- W2038204022 cites W2006521244 @default.
- W2038204022 cites W2010072875 @default.
- W2038204022 cites W2010817360 @default.
- W2038204022 cites W2012423481 @default.
- W2038204022 cites W2015409726 @default.
- W2038204022 cites W2015791855 @default.
- W2038204022 cites W2015896540 @default.
- W2038204022 cites W2017582048 @default.
- W2038204022 cites W2026043938 @default.
- W2038204022 cites W2028672566 @default.
- W2038204022 cites W2032169064 @default.
- W2038204022 cites W2032346440 @default.
- W2038204022 cites W2035433348 @default.
- W2038204022 cites W2035960239 @default.
- W2038204022 cites W2039768665 @default.
- W2038204022 cites W2042209841 @default.
- W2038204022 cites W2043796950 @default.
- W2038204022 cites W2043823247 @default.
- W2038204022 cites W2049678142 @default.
- W2038204022 cites W2053133856 @default.
- W2038204022 cites W2059637973 @default.
- W2038204022 cites W2065945819 @default.
- W2038204022 cites W2067427665 @default.
- W2038204022 cites W2069696766 @default.
- W2038204022 cites W2070255464 @default.
- W2038204022 cites W2071669694 @default.
- W2038204022 cites W2073164360 @default.
- W2038204022 cites W2073953515 @default.
- W2038204022 cites W2074059194 @default.
- W2038204022 cites W2074795687 @default.
- W2038204022 cites W2079053367 @default.
- W2038204022 cites W2079205791 @default.
- W2038204022 cites W2080503511 @default.
- W2038204022 cites W2080945886 @default.
- W2038204022 cites W2084423382 @default.
- W2038204022 cites W2084469556 @default.
- W2038204022 cites W2086104998 @default.
- W2038204022 cites W2086800018 @default.
- W2038204022 cites W2091246078 @default.
- W2038204022 cites W2091836237 @default.
- W2038204022 cites W2094220982 @default.
- W2038204022 cites W2101779179 @default.
- W2038204022 cites W2104603012 @default.
- W2038204022 cites W2104991162 @default.
- W2038204022 cites W2108916769 @default.
- W2038204022 cites W2109844028 @default.
- W2038204022 cites W2110572783 @default.
- W2038204022 cites W2112102302 @default.
- W2038204022 cites W2115848892 @default.
- W2038204022 cites W2117290213 @default.
- W2038204022 cites W2118751252 @default.
- W2038204022 cites W2123732274 @default.
- W2038204022 cites W2125284377 @default.
- W2038204022 cites W2133084626 @default.
- W2038204022 cites W2136732030 @default.
- W2038204022 cites W2136749650 @default.
- W2038204022 cites W2141640777 @default.
- W2038204022 cites W2144233065 @default.
- W2038204022 cites W2147026827 @default.
- W2038204022 cites W2149128350 @default.
- W2038204022 cites W2149698238 @default.