FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2038206593> ?p ?o ?g. }

• W2038206593 endingPage "311" @default.
• W2038206593 startingPage "304" @default.
• W2038206593 abstract "Ulcerative colitis (UC) and, to a lesser extent, Crohn's disease (CD) are associated with a reduction of the protective mucus layer in the large intestine; the role of this alteration in the pathogenesis of either disease is, however, not clear. To learn more about the molecular mechanism of the alteration of the mucus layer, the expression of the main intestinal mucin, MUC2, was investigated in relation to inflammation and dysplasia. Formalin-fixed, paraffin-embedded biopsies from 70 patients with UC and 16 patients with CD, and 13 biopsies from normal colonic mucosa, were used for detection of MUC2 mRNA by in situ hybridization with the SMUC41 probe, and MUC2 protein by immunohistochemistry with the antibody CCP58. The steady-state concentration of MUC2 mRNA was not affected by UC or CD. By contrast, the amount of the detectable MUC2 protein, assessed as the immunoreactive score (IRS), was significantly (p < 0·0001) increased in UC (IRS = 8·0 ± 3·8) and CD (8·0 ± 3·7), compared with the normal colonic mucosa (IRS = 2·0 ± 1·5). This alteration occurred in the inactive phase of inflammation and persisted in the active phase of the disease. It was also observed during bacterial or protozoal inflammation (n = 7). The IRS values did not correlate with the grade of inflammation or dysplasia. Simultaneous histochemistry with high iron diamine and immunohistochemistry indicated that the increase of detectable MUC2 is concomitant with low mucin sulphation in the same cells. These data indicate that the strong MUC2 protein staining in colonic mucosa of patients with UC or CD is due to a long-term alteration of the post-transcriptional modification of the MUC2 molecule, leading to its better detectability by the anti-MUC2 antibody CCP58. This alteration, induced by the inflammatory process, may affect the gel thickness and may contribute to a protracted autoimmune response. Copyright © 1999 John Wiley & Sons, Ltd." @default.
• W2038206593 created "2016-06-24" @default.
• W2038206593 creator A5013497290 @default.
• W2038206593 creator A5020722745 @default.
• W2038206593 creator A5020881329 @default.
• W2038206593 creator A5023121641 @default.
• W2038206593 creator A5060504684 @default.
• W2038206593 creator A5071093377 @default.
• W2038206593 creator A5075223976 @default.
• W2038206593 creator A5077428594 @default.
• W2038206593 creator A5087136118 @default.
• W2038206593 date "1999-07-01" @default.
• W2038206593 modified "2023-10-18" @default.
• W2038206593 title "Defective post-transcriptional processing of MUC2 mucin in ulcerative colitis and in Crohn's disease increases detectability of the MUC2 protein core" @default.
• W2038206593 cites W1548863075 @default.
• W2038206593 cites W1965983975 @default.
• W2038206593 cites W1973796794 @default.
• W2038206593 cites W1976470241 @default.
• W2038206593 cites W1988914875 @default.
• W2038206593 cites W1990059998 @default.
• W2038206593 cites W2005440101 @default.
• W2038206593 cites W2007103510 @default.
• W2038206593 cites W2014439427 @default.
• W2038206593 cites W2023857009 @default.
• W2038206593 cites W2053121074 @default.
• W2038206593 cites W2064656822 @default.
• W2038206593 cites W2070248062 @default.
• W2038206593 cites W2084383930 @default.
• W2038206593 cites W2090836097 @default.
• W2038206593 cites W2091996810 @default.
• W2038206593 cites W2097702986 @default.
• W2038206593 cites W2100672979 @default.
• W2038206593 cites W2106212265 @default.
• W2038206593 cites W2116598231 @default.
• W2038206593 cites W2122386490 @default.
• W2038206593 cites W2126545869 @default.
• W2038206593 cites W2132744721 @default.
• W2038206593 cites W2138597790 @default.
• W2038206593 cites W2144642513 @default.
• W2038206593 cites W2154907639 @default.
• W2038206593 cites W2300482125 @default.
• W2038206593 cites W2334979906 @default.
• W2038206593 doi "https://doi.org/10.1002/(sici)1096-9896(199907)188:3<304::aid-path375>3.0.co;2-a" @default.
• W2038206593 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10419600" @default.
• W2038206593 hasPublicationYear "1999" @default.
• W2038206593 type Work @default.
• W2038206593 sameAs 2038206593 @default.
• W2038206593 citedByCount "46" @default.
• W2038206593 countsByYear W20382065932012 @default.
• W2038206593 countsByYear W20382065932013 @default.
• W2038206593 countsByYear W20382065932014 @default.
• W2038206593 countsByYear W20382065932016 @default.
• W2038206593 countsByYear W20382065932017 @default.
• W2038206593 countsByYear W20382065932020 @default.
• W2038206593 countsByYear W20382065932021 @default.
• W2038206593 countsByYear W20382065932022 @default.
• W2038206593 countsByYear W20382065932023 @default.
• W2038206593 crossrefType "journal-article" @default.
• W2038206593 hasAuthorship W2038206593A5013497290 @default.
• W2038206593 hasAuthorship W2038206593A5020722745 @default.
• W2038206593 hasAuthorship W2038206593A5020881329 @default.
• W2038206593 hasAuthorship W2038206593A5023121641 @default.
• W2038206593 hasAuthorship W2038206593A5060504684 @default.
• W2038206593 hasAuthorship W2038206593A5071093377 @default.
• W2038206593 hasAuthorship W2038206593A5075223976 @default.
• W2038206593 hasAuthorship W2038206593A5077428594 @default.
• W2038206593 hasAuthorship W2038206593A5087136118 @default.
• W2038206593 hasConcept C104317684 @default.
• W2038206593 hasConcept C126322002 @default.
• W2038206593 hasConcept C142724271 @default.
• W2038206593 hasConcept C150194340 @default.
• W2038206593 hasConcept C179264091 @default.
• W2038206593 hasConcept C18903297 @default.
• W2038206593 hasConcept C203014093 @default.
• W2038206593 hasConcept C204232928 @default.
• W2038206593 hasConcept C2775862500 @default.
• W2038206593 hasConcept C2775894508 @default.
• W2038206593 hasConcept C2776914184 @default.
• W2038206593 hasConcept C2777116383 @default.
• W2038206593 hasConcept C2777312293 @default.
• W2038206593 hasConcept C2779134260 @default.
• W2038206593 hasConcept C2780479503 @default.
• W2038206593 hasConcept C2780942790 @default.
• W2038206593 hasConcept C3019368612 @default.
• W2038206593 hasConcept C55493867 @default.
• W2038206593 hasConcept C71924100 @default.
• W2038206593 hasConcept C86803240 @default.
• W2038206593 hasConcept C90924648 @default.
• W2038206593 hasConceptScore W2038206593C104317684 @default.
• W2038206593 hasConceptScore W2038206593C126322002 @default.
• W2038206593 hasConceptScore W2038206593C142724271 @default.
• W2038206593 hasConceptScore W2038206593C150194340 @default.
• W2038206593 hasConceptScore W2038206593C179264091 @default.
• W2038206593 hasConceptScore W2038206593C18903297 @default.
• W2038206593 hasConceptScore W2038206593C203014093 @default.
• W2038206593 hasConceptScore W2038206593C204232928 @default.
• W2038206593 hasConceptScore W2038206593C2775862500 @default.
• W2038206593 hasConceptScore W2038206593C2775894508 @default.

• next