FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2038207785> ?p ?o ?g. }

• W2038207785 abstract "Autoimmune myocarditis develops after the presentation of heart-specific antigens to autoaggressive CD4(+) T cells and after inflammation has infiltrated the tissues. To shed light on global changes in the gene expression of autoimmune myocarditis and to gain further insight into the molecular mechanisms underlying the genesis of myocarditis, we conducted a comprehensive microarray analysis of mRNA using an experimental mouse autoimmune myocarditis model via immunization with alpha-myosin heavy chain-derived peptides. Of over 39,000 transcripts on a high density oligonucleotide microarray, 466 were under-expressed and 241 over-expressed by >or= 1.5-fold compared with the controls in BALB/C mouse with autoimmune myocarditis. In this paper, we list the top 50 up-regulated genes related to the immune response. These altered genes encode for leukocyte-specific markers and receptors, the histocompatibility complex, cytokines/receptors, chemokines/receptors, adhesion molecules, components of the complement cascade, and signal transduction-related molecules. Interestingly, matrix metalloproteinases (MMPs) such as MMP-3 and MMP-9 were up-regulated, as further revealed by the reverse transcriptase-polymerase chain reaction (RT-PCR) and immunohistochemistry assays. This indicates that MMPs may act as major regulators of the cytokine profile. Together, these findings provide new insight into the molecular events associated with the mechanism of the autoimmune genesis of myocarditis." @default.
• W2038207785 created "2016-06-24" @default.
• W2038207785 creator A5010434230 @default.
• W2038207785 creator A5018780864 @default.
• W2038207785 creator A5033415932 @default.
• W2038207785 creator A5041677976 @default.
• W2038207785 creator A5057016325 @default.
• W2038207785 creator A5060344532 @default.
• W2038207785 creator A5064891212 @default.
• W2038207785 creator A5078874926 @default.
• W2038207785 date "2007-01-01" @default.
• W2038207785 modified "2023-09-29" @default.
• W2038207785 title "Microarray analysis reveals the role of matrix metalloproteinases in mouse experimental autoimmune myocarditis induced by cardiac myosin peptides" @default.
• W2038207785 cites W1495319615 @default.
• W2038207785 cites W1500257692 @default.
• W2038207785 cites W1578923163 @default.
• W2038207785 cites W1969412141 @default.
• W2038207785 cites W197305849 @default.
• W2038207785 cites W1997253974 @default.
• W2038207785 cites W1997616700 @default.
• W2038207785 cites W2011642355 @default.
• W2038207785 cites W2014971932 @default.
• W2038207785 cites W2019926860 @default.
• W2038207785 cites W2023697024 @default.
• W2038207785 cites W2035579845 @default.
• W2038207785 cites W2040977790 @default.
• W2038207785 cites W2047505191 @default.
• W2038207785 cites W2059277480 @default.
• W2038207785 cites W2061465302 @default.
• W2038207785 cites W2064860759 @default.
• W2038207785 cites W2065086568 @default.
• W2038207785 cites W2093032251 @default.
• W2038207785 cites W2124894661 @default.
• W2038207785 cites W2128049766 @default.
• W2038207785 cites W2146909631 @default.
• W2038207785 cites W2148204112 @default.
• W2038207785 cites W2151148996 @default.
• W2038207785 cites W2152090961 @default.
• W2038207785 cites W2152487395 @default.
• W2038207785 cites W2158858936 @default.
• W2038207785 cites W2160147662 @default.
• W2038207785 cites W2160909954 @default.
• W2038207785 cites W2163118333 @default.
• W2038207785 cites W2252988123 @default.
• W2038207785 cites W2410227994 @default.
• W2038207785 cites W2415194669 @default.
• W2038207785 cites W4241118157 @default.
• W2038207785 doi "https://doi.org/10.2478/s11658-007-0003-4" @default.
• W2038207785 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6275600" @default.
• W2038207785 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17235437" @default.
• W2038207785 hasPublicationYear "2007" @default.
• W2038207785 type Work @default.
• W2038207785 sameAs 2038207785 @default.
• W2038207785 citedByCount "8" @default.
• W2038207785 countsByYear W20382077852012 @default.
• W2038207785 countsByYear W20382077852017 @default.
• W2038207785 countsByYear W20382077852021 @default.
• W2038207785 crossrefType "journal-article" @default.
• W2038207785 hasAuthorship W2038207785A5010434230 @default.
• W2038207785 hasAuthorship W2038207785A5018780864 @default.
• W2038207785 hasAuthorship W2038207785A5033415932 @default.
• W2038207785 hasAuthorship W2038207785A5041677976 @default.
• W2038207785 hasAuthorship W2038207785A5057016325 @default.
• W2038207785 hasAuthorship W2038207785A5060344532 @default.
• W2038207785 hasAuthorship W2038207785A5064891212 @default.
• W2038207785 hasAuthorship W2038207785A5078874926 @default.
• W2038207785 hasBestOaLocation W20382077851 @default.
• W2038207785 hasConcept C104317684 @default.
• W2038207785 hasConcept C13373296 @default.
• W2038207785 hasConcept C150194340 @default.
• W2038207785 hasConcept C153911025 @default.
• W2038207785 hasConcept C164705383 @default.
• W2038207785 hasConcept C170493617 @default.
• W2038207785 hasConcept C203014093 @default.
• W2038207785 hasConcept C207936829 @default.
• W2038207785 hasConcept C2780875844 @default.
• W2038207785 hasConcept C54355233 @default.
• W2038207785 hasConcept C71924100 @default.
• W2038207785 hasConcept C8415881 @default.
• W2038207785 hasConcept C86803240 @default.
• W2038207785 hasConcept C8891405 @default.
• W2038207785 hasConceptScore W2038207785C104317684 @default.
• W2038207785 hasConceptScore W2038207785C13373296 @default.
• W2038207785 hasConceptScore W2038207785C150194340 @default.
• W2038207785 hasConceptScore W2038207785C153911025 @default.
• W2038207785 hasConceptScore W2038207785C164705383 @default.
• W2038207785 hasConceptScore W2038207785C170493617 @default.
• W2038207785 hasConceptScore W2038207785C203014093 @default.
• W2038207785 hasConceptScore W2038207785C207936829 @default.
• W2038207785 hasConceptScore W2038207785C2780875844 @default.
• W2038207785 hasConceptScore W2038207785C54355233 @default.
• W2038207785 hasConceptScore W2038207785C71924100 @default.
• W2038207785 hasConceptScore W2038207785C8415881 @default.
• W2038207785 hasConceptScore W2038207785C86803240 @default.
• W2038207785 hasConceptScore W2038207785C8891405 @default.
• W2038207785 hasIssue "2" @default.
• W2038207785 hasLocation W20382077851 @default.
• W2038207785 hasLocation W20382077852 @default.
• W2038207785 hasLocation W20382077853 @default.
• W2038207785 hasLocation W20382077854 @default.

• next