FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2038212913> ?p ?o ?g. }

• W2038212913 endingPage "893" @default.
• W2038212913 startingPage "881" @default.
• W2038212913 abstract "Oxidative damage of nucleotides within DNA or precursor pools caused by oxygen radicals is thought to play an important role in spontaneous mutagenesis, as well as carcinogenesis and aging. In particular, 8-oxodGTP and 2-OHdATP are potent mutagenic substrate for DNA synthesis. Mammalian MTH1 catalyzes hydrolysis of these mutagenic substrates, suggesting that it functions to prevent mutagenesis caused by these oxidized nucleotides. We have established MTH1(-/-) mice lacking the 8-oxodGTPase activity, which were shown to be susceptible to lung, liver and stomach cancers. To examine in vivo mutation events due to the MTH1-deficiency, a reporter gene, rpsL of Escherichia coli, was introduced into MTH1(-/-) mice. Interestingly, the net frequency of rpsL(-) forward mutants showed no apparent increase in MTH1(-/-) mice as compared to MTH1(+/+) mice. However, we found differences between these two genotypes in the class- and site-distributions of the rpsL(-) mutations recovered from the mice. Unlike MutT-deficient E. coli showing 1000-fold higher frequency of A:T-->C:G transversion than the wild type cells, an increase in frequency of A:T-->C:G transversion was not evident in MTH1 nullizygous mice. Nevertheless, the frequency of single-base frameshifts at mononucleotide runs was 5.7-fold higher in spleens of MTH1(-/-) mice than in those of wild type mice. Since the elevated incidence of single-base frameshifts at mononucleotide runs is a hallmark of the defect in MSH2-dependent mismatch repair system, this weak site-specific mutator effect of MTH1(-/-) mice could be attributed to a partial sequestration of the mismatch repair function that may act to correct mispairs with the oxidized nucleotides. Consistent with this hypothesis, a significant increase in the frequency of G:C-->T:A transversions was observed with MTH1(-/-) MSH2(-/-) mice over MSH2(-/-) mice alone. These results suggest a possible involvement of multiple anti-mutagenic pathways, including the MTH1 protein and other repair system(s), in mutagenesis caused by the oxidized nucleotides." @default.
• W2038212913 created "2016-06-24" @default.
• W2038212913 creator A5014547538 @default.
• W2038212913 creator A5025959729 @default.
• W2038212913 creator A5032189724 @default.
• W2038212913 creator A5034200367 @default.
• W2038212913 creator A5037987804 @default.
• W2038212913 creator A5040582134 @default.
• W2038212913 creator A5040993057 @default.
• W2038212913 creator A5057146510 @default.
• W2038212913 creator A5065943236 @default.
• W2038212913 date "2002-11-01" @default.
• W2038212913 modified "2023-10-15" @default.
• W2038212913 title "Mutational specificity of mice defective in the MTH1 and/or the MSH2 genes" @default.
• W2038212913 cites W1484882395 @default.
• W2038212913 cites W1558506222 @default.
• W2038212913 cites W1615875025 @default.
• W2038212913 cites W1965121800 @default.
• W2038212913 cites W1967861989 @default.
• W2038212913 cites W1968708903 @default.
• W2038212913 cites W1975995252 @default.
• W2038212913 cites W1976260015 @default.
• W2038212913 cites W1976856900 @default.
• W2038212913 cites W1983139318 @default.
• W2038212913 cites W1996057940 @default.
• W2038212913 cites W2003711294 @default.
• W2038212913 cites W2010055022 @default.
• W2038212913 cites W2011804819 @default.
• W2038212913 cites W2023677185 @default.
• W2038212913 cites W2025740772 @default.
• W2038212913 cites W2029243559 @default.
• W2038212913 cites W2034269086 @default.
• W2038212913 cites W2035310307 @default.
• W2038212913 cites W2045012725 @default.
• W2038212913 cites W2052429166 @default.
• W2038212913 cites W2053520887 @default.
• W2038212913 cites W2067951632 @default.
• W2038212913 cites W2071858293 @default.
• W2038212913 cites W2075960489 @default.
• W2038212913 cites W2077990737 @default.
• W2038212913 cites W2083384362 @default.
• W2038212913 cites W2089160559 @default.
• W2038212913 cites W2091403301 @default.
• W2038212913 cites W2095301528 @default.
• W2038212913 cites W2113320982 @default.
• W2038212913 cites W2132935078 @default.
• W2038212913 cites W2153315312 @default.
• W2038212913 cites W2166586340 @default.
• W2038212913 cites W2319047082 @default.
• W2038212913 doi "https://doi.org/10.1016/s1568-7864(02)00113-1" @default.
• W2038212913 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12531017" @default.
• W2038212913 hasPublicationYear "2002" @default.
• W2038212913 type Work @default.
• W2038212913 sameAs 2038212913 @default.
• W2038212913 citedByCount "76" @default.
• W2038212913 countsByYear W20382129132012 @default.
• W2038212913 countsByYear W20382129132013 @default.
• W2038212913 countsByYear W20382129132014 @default.
• W2038212913 countsByYear W20382129132015 @default.
• W2038212913 countsByYear W20382129132016 @default.
• W2038212913 countsByYear W20382129132017 @default.
• W2038212913 countsByYear W20382129132018 @default.
• W2038212913 countsByYear W20382129132019 @default.
• W2038212913 countsByYear W20382129132020 @default.
• W2038212913 countsByYear W20382129132021 @default.
• W2038212913 countsByYear W20382129132022 @default.
• W2038212913 countsByYear W20382129132023 @default.
• W2038212913 crossrefType "journal-article" @default.
• W2038212913 hasAuthorship W2038212913A5014547538 @default.
• W2038212913 hasAuthorship W2038212913A5025959729 @default.
• W2038212913 hasAuthorship W2038212913A5032189724 @default.
• W2038212913 hasAuthorship W2038212913A5034200367 @default.
• W2038212913 hasAuthorship W2038212913A5037987804 @default.
• W2038212913 hasAuthorship W2038212913A5040582134 @default.
• W2038212913 hasAuthorship W2038212913A5040993057 @default.
• W2038212913 hasAuthorship W2038212913A5057146510 @default.
• W2038212913 hasAuthorship W2038212913A5065943236 @default.
• W2038212913 hasConcept C104317684 @default.
• W2038212913 hasConcept C134935766 @default.
• W2038212913 hasConcept C143065580 @default.
• W2038212913 hasConcept C153911025 @default.
• W2038212913 hasConcept C16318435 @default.
• W2038212913 hasConcept C2779115348 @default.
• W2038212913 hasConcept C501734568 @default.
• W2038212913 hasConcept C512185932 @default.
• W2038212913 hasConcept C54355233 @default.
• W2038212913 hasConcept C547475151 @default.
• W2038212913 hasConcept C552990157 @default.
• W2038212913 hasConcept C55493867 @default.
• W2038212913 hasConcept C555283112 @default.
• W2038212913 hasConcept C60748783 @default.
• W2038212913 hasConcept C64872895 @default.
• W2038212913 hasConcept C86803240 @default.
• W2038212913 hasConceptScore W2038212913C104317684 @default.
• W2038212913 hasConceptScore W2038212913C134935766 @default.
• W2038212913 hasConceptScore W2038212913C143065580 @default.
• W2038212913 hasConceptScore W2038212913C153911025 @default.
• W2038212913 hasConceptScore W2038212913C16318435 @default.

• next