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- W2038221005 abstract "To study the structure–function relationship of the oxidative-damage effect of ascorbic acid, we have focused on the interaction between plasmid DNA pUC19 and a series of ascorbic acid derivatives modified on different OH groups in the presence of transition metal ions. Some ascorbic acid derivatives can selectively cleave plasmid DNA from Form I to Form II in the presence of low concentration of Cu2+ just like ascorbic acid itself, while other derivatives oxidatively damage plasmid DNA slightly. We found that those derivatives with unattached 2-OH and 3-OH groups retain the ability to cleave the plasmid DNA. The derivatives that have been methylated on 2-OH or 3-OH can only cleave plasmid DNA softly, and those derivatives that have been protected on both 2-OH and 3-OH can hardly exert an oxidative damage on plasmid DNA under the same condition. Form these results, we can draw the conclusion that 2-OH and 3-OH groups of the ascorbic acid molecule contribute most to this biological activity." @default.
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- W2038221005 date "2006-09-01" @default.
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- W2038221005 title "The Oxidative Damage of Plasmid DNA by Ascorbic Acid Derivativesin vitro: The First Research on the Relationship between the Structure of Ascorbic Acid and the Oxidative Damage of Plasmid DNA" @default.
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- W2038221005 doi "https://doi.org/10.1002/cbdv.200690104" @default.
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