FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2038221036> ?p ?o ?g. }

• W2038221036 endingPage "221" @default.
• W2038221036 startingPage "212" @default.
• W2038221036 abstract "The glutamate–glutamine cycle between neurons and glia is tightly related to excitatory glutamatergic and inhibitory GABAergic regulation in brain. The role of this neuron–astrocyte cross‐talk on the neurotoxicity induced by amphetamines is not understood. Also, the impact of neurotoxic doses of amphetamines on the balance between glutamatergic and GABAergic circuits is largely unknown. The aim of this work was to assess the acute effect of a neurotoxic regimen of amphetamine (AMPH) on glutamine (GLN, an astrocytic marker) levels and on glutamine/glutamate (an index for glutamate–glutamine cycle) and GABA/glutamate ratios in rat brain. Sprague‐Dawley rats were sacrificed 4 and 24 h after a single‐dose regimen of AMPH (30 mg/kg, i.p.), and the caudate–putamen (CPu), frontal cortex (FC), and hippocampus (Hp) were dissected for analysis of glutamate (GLU), γ‐aminobutyric acid (GABA), and GLN. The total content of these amino acids was measured using a microbore HPLC electrochemical detector. Although AMPH did not change GLU levels, it increased both GLN content and GLN/GLU ratio (160–469%) at 4 h, but not at 24 h, in all regions after injection. Striatal GABA levels and GABA/GLU ratio were increased (46 and 100%, respectively) at 24 h. In hippocampus the GABA/GLU increase (60%) occurred as early as 4 h after treatment. To the contrary, AMPH exerted no effect in GABA/GLU balance in frontal cortex. These data strongly suggest that this neurotoxic AMPH regimen provoked an early increase in the glutamate–glutamine cycle between neurons and glia. This increase may ultimately lead to an upregulation of the inhibitory system as a compensatory response." @default.
• W2038221036 created "2016-06-24" @default.
• W2038221036 creator A5016755104 @default.
• W2038221036 creator A5019977600 @default.
• W2038221036 creator A5038290685 @default.
• W2038221036 creator A5069063048 @default.
• W2038221036 creator A5077803549 @default.
• W2038221036 creator A5080956531 @default.
• W2038221036 creator A5084041401 @default.
• W2038221036 creator A5009664826 @default.
• W2038221036 date "2008-10-01" @default.
• W2038221036 modified "2023-09-24" @default.
• W2038221036 title "Acute Increase of the Glutamate-Glutamine Cycling in Discrete Brain Areas after Administration of a Single Dose of Amphetamine" @default.
• W2038221036 cites W1610329392 @default.
• W2038221036 cites W1947652441 @default.
• W2038221036 cites W1966063941 @default.
• W2038221036 cites W1966157739 @default.
• W2038221036 cites W1966719975 @default.
• W2038221036 cites W1974253563 @default.
• W2038221036 cites W1987936509 @default.
• W2038221036 cites W1989978915 @default.
• W2038221036 cites W1991483861 @default.
• W2038221036 cites W1992521533 @default.
• W2038221036 cites W1994909073 @default.
• W2038221036 cites W1995227276 @default.
• W2038221036 cites W1996333348 @default.
• W2038221036 cites W2001301650 @default.
• W2038221036 cites W2005517207 @default.
• W2038221036 cites W2008599960 @default.
• W2038221036 cites W2012394584 @default.
• W2038221036 cites W2017044128 @default.
• W2038221036 cites W2019555907 @default.
• W2038221036 cites W2021938735 @default.
• W2038221036 cites W2025478209 @default.
• W2038221036 cites W2029624481 @default.
• W2038221036 cites W2030646074 @default.
• W2038221036 cites W2040690369 @default.
• W2038221036 cites W2045669174 @default.
• W2038221036 cites W2050984501 @default.
• W2038221036 cites W2056839574 @default.
• W2038221036 cites W2060720611 @default.
• W2038221036 cites W2065663423 @default.
• W2038221036 cites W2067795636 @default.
• W2038221036 cites W2070985058 @default.
• W2038221036 cites W2072481708 @default.
• W2038221036 cites W2072761349 @default.
• W2038221036 cites W2072849537 @default.
• W2038221036 cites W2079606432 @default.
• W2038221036 cites W2083217067 @default.
• W2038221036 cites W2084837506 @default.
• W2038221036 cites W2085673544 @default.
• W2038221036 cites W2086446180 @default.
• W2038221036 cites W2091571497 @default.
• W2038221036 cites W2093377694 @default.
• W2038221036 cites W2109740923 @default.
• W2038221036 cites W2114017269 @default.
• W2038221036 cites W2114705177 @default.
• W2038221036 cites W2118447727 @default.
• W2038221036 cites W2130324930 @default.
• W2038221036 cites W2132469266 @default.
• W2038221036 cites W2143767632 @default.
• W2038221036 cites W2175913266 @default.
• W2038221036 cites W2415602334 @default.
• W2038221036 cites W345805398 @default.
• W2038221036 doi "https://doi.org/10.1196/annals.1432.040" @default.
• W2038221036 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18991867" @default.
• W2038221036 hasPublicationYear "2008" @default.
• W2038221036 type Work @default.
• W2038221036 sameAs 2038221036 @default.
• W2038221036 citedByCount "19" @default.
• W2038221036 countsByYear W20382210362012 @default.
• W2038221036 countsByYear W20382210362014 @default.
• W2038221036 countsByYear W20382210362015 @default.
• W2038221036 countsByYear W20382210362016 @default.
• W2038221036 countsByYear W20382210362017 @default.
• W2038221036 countsByYear W20382210362019 @default.
• W2038221036 countsByYear W20382210362020 @default.
• W2038221036 countsByYear W20382210362021 @default.
• W2038221036 crossrefType "journal-article" @default.
• W2038221036 hasAuthorship W2038221036A5009664826 @default.
• W2038221036 hasAuthorship W2038221036A5016755104 @default.
• W2038221036 hasAuthorship W2038221036A5019977600 @default.
• W2038221036 hasAuthorship W2038221036A5038290685 @default.
• W2038221036 hasAuthorship W2038221036A5069063048 @default.
• W2038221036 hasAuthorship W2038221036A5077803549 @default.
• W2038221036 hasAuthorship W2038221036A5080956531 @default.
• W2038221036 hasAuthorship W2038221036A5084041401 @default.
• W2038221036 hasConcept C126322002 @default.
• W2038221036 hasConcept C134018914 @default.
• W2038221036 hasConcept C170493617 @default.
• W2038221036 hasConcept C17077164 @default.
• W2038221036 hasConcept C185592680 @default.
• W2038221036 hasConcept C2777193897 @default.
• W2038221036 hasConcept C2777771985 @default.
• W2038221036 hasConcept C2779177108 @default.
• W2038221036 hasConcept C2779349466 @default.
• W2038221036 hasConcept C2779491297 @default.
• W2038221036 hasConcept C2780648746 @default.

• next