FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2038224910> ?p ?o ?g. }

• W2038224910 endingPage "837" @default.
• W2038224910 startingPage "833" @default.
• W2038224910 abstract "<h3>Abstract</h3> Spontaneous mutations can alter tissue dynamics and lead to cancer initiation. While large-scale sequencing projects have illustrated processes that influence somatic mutation and subsequent tumour evolution, the mutational dynamics operating in the very early stages of cancer development are currently not well understood. In order to explore mutational dynamics in the early stages of cancer evolution we exploited neoplasia arising spontaneously in the <i>Drosophila</i> intestine. We analysed whole-genome sequencing data through the development of a dedicated bioinformatic pipeline to detect structural variants, single nucleotide variants, and indels. We found neoplasia formation to be driven largely through the inactivation of <i>Notch</i> by structural variants, many of which involve highly complex genomic rearrangements. Strikingly, the genome-wide mutational burden of neoplasia - at six weeks of age - was found to be similar to that of several human cancers. Finally, we identified genomic features associated with spontaneous mutation and defined the evolutionary dynamics and mutational landscape operating within intestinal neoplasia over the short lifespan of the adult fly. Our findings provide unique insight into mutational dynamics operating over a short time scale in the genetic model system, <i>Drosophila melanogaster</i>." @default.
• W2038224910 created "2016-06-24" @default.
• W2038224910 creator A5068470671 @default.
• W2038224910 creator A5081694296 @default.
• W2038224910 date "1987-11-01" @default.
• W2038224910 modified "2023-10-18" @default.
• W2038224910 title "Studying lung cancer in the laboratory--2: Chemosensitivity testing." @default.
• W2038224910 cites W1480773154 @default.
• W2038224910 cites W1594710953 @default.
• W2038224910 cites W1820859680 @default.
• W2038224910 cites W1964588727 @default.
• W2038224910 cites W1968589467 @default.
• W2038224910 cites W1978689713 @default.
• W2038224910 cites W1981776296 @default.
• W2038224910 cites W1986341126 @default.
• W2038224910 cites W2010599496 @default.
• W2038224910 cites W2023780688 @default.
• W2038224910 cites W2026182412 @default.
• W2038224910 cites W2029452362 @default.
• W2038224910 cites W2031404591 @default.
• W2038224910 cites W2053289735 @default.
• W2038224910 cites W2060524209 @default.
• W2038224910 cites W2064974418 @default.
• W2038224910 cites W2066485365 @default.
• W2038224910 cites W2082834104 @default.
• W2038224910 cites W2085737063 @default.
• W2038224910 cites W2117025269 @default.
• W2038224910 cites W2150155103 @default.
• W2038224910 cites W2154720054 @default.
• W2038224910 cites W2161171212 @default.
• W2038224910 cites W2242232701 @default.
• W2038224910 cites W2254085974 @default.
• W2038224910 cites W2340393179 @default.
• W2038224910 cites W2396490737 @default.
• W2038224910 cites W2409783420 @default.
• W2038224910 cites W2418304377 @default.
• W2038224910 cites W4253186968 @default.
• W2038224910 cites W62466528 @default.
• W2038224910 doi "https://doi.org/10.1136/thx.42.11.833" @default.
• W2038224910 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/461005" @default.
• W2038224910 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3321542" @default.
• W2038224910 hasPublicationYear "1987" @default.
• W2038224910 type Work @default.
• W2038224910 sameAs 2038224910 @default.
• W2038224910 citedByCount "0" @default.
• W2038224910 crossrefType "journal-article" @default.
• W2038224910 hasAuthorship W2038224910A5068470671 @default.
• W2038224910 hasAuthorship W2038224910A5081694296 @default.
• W2038224910 hasBestOaLocation W20382249101 @default.
• W2038224910 hasConcept C104317684 @default.
• W2038224910 hasConcept C119054055 @default.
• W2038224910 hasConcept C121608353 @default.
• W2038224910 hasConcept C135763542 @default.
• W2038224910 hasConcept C141231307 @default.
• W2038224910 hasConcept C153209595 @default.
• W2038224910 hasConcept C16671776 @default.
• W2038224910 hasConcept C171578705 @default.
• W2038224910 hasConcept C2780104201 @default.
• W2038224910 hasConcept C2908647359 @default.
• W2038224910 hasConcept C2910240311 @default.
• W2038224910 hasConcept C501734568 @default.
• W2038224910 hasConcept C54355233 @default.
• W2038224910 hasConcept C70721500 @default.
• W2038224910 hasConcept C71924100 @default.
• W2038224910 hasConcept C86803240 @default.
• W2038224910 hasConcept C99454951 @default.
• W2038224910 hasConceptScore W2038224910C104317684 @default.
• W2038224910 hasConceptScore W2038224910C119054055 @default.
• W2038224910 hasConceptScore W2038224910C121608353 @default.
• W2038224910 hasConceptScore W2038224910C135763542 @default.
• W2038224910 hasConceptScore W2038224910C141231307 @default.
• W2038224910 hasConceptScore W2038224910C153209595 @default.
• W2038224910 hasConceptScore W2038224910C16671776 @default.
• W2038224910 hasConceptScore W2038224910C171578705 @default.
• W2038224910 hasConceptScore W2038224910C2780104201 @default.
• W2038224910 hasConceptScore W2038224910C2908647359 @default.
• W2038224910 hasConceptScore W2038224910C2910240311 @default.
• W2038224910 hasConceptScore W2038224910C501734568 @default.
• W2038224910 hasConceptScore W2038224910C54355233 @default.
• W2038224910 hasConceptScore W2038224910C70721500 @default.
• W2038224910 hasConceptScore W2038224910C71924100 @default.
• W2038224910 hasConceptScore W2038224910C86803240 @default.
• W2038224910 hasConceptScore W2038224910C99454951 @default.
• W2038224910 hasIssue "11" @default.
• W2038224910 hasLocation W20382249101 @default.
• W2038224910 hasLocation W20382249102 @default.
• W2038224910 hasLocation W20382249103 @default.
• W2038224910 hasLocation W20382249104 @default.
• W2038224910 hasOpenAccess W2038224910 @default.
• W2038224910 hasPrimaryLocation W20382249101 @default.
• W2038224910 hasRelatedWork W1590731218 @default.
• W2038224910 hasRelatedWork W2069184423 @default.
• W2038224910 hasRelatedWork W2130150686 @default.
• W2038224910 hasRelatedWork W2140698435 @default.
• W2038224910 hasRelatedWork W2142669469 @default.
• W2038224910 hasRelatedWork W2146849562 @default.
• W2038224910 hasRelatedWork W2410041588 @default.
• W2038224910 hasRelatedWork W2579125832 @default.

• next