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- W2038238210 abstract "The hypotonic preswelling method for encapsulation of drugs in intact human erythrocytes was evaluated using enalaprilat as a model peptide-like drug. Several process variables, including volume, concentration, pH, and method of addition of drug solution, type of erythrocyte-suspending medium, temperature, initial packed density of erythrocytes, and individual process steps, were exploited with respect to their effects on the loading parameters (i.e., loaded amount, efficiency of entrapment, and cell recovery). In addition, the probable mechanism by which the erythrocytes were loaded by enalaprilat at the point of lysis was shown to be a simple concentration gradient-based diffusion through membrane openings occurring on hemolysis. Finally, the adopted method was validated, and the results showed a considerable degree of reproducibility and recovery for the entire loading procedure." @default.
- W2038238210 created "2016-06-24" @default.
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- W2038238210 date "2000-01-01" @default.
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- W2038238210 title "Evaluation of Hypotonic Preswelling Method for Encapsulation of Enalaprilat in Intact Human Erythrocytes" @default.
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- W2038238210 doi "https://doi.org/10.1081/ddc-100102306" @default.
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