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• W2038240423 abstract "Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DCBackground:The potential of miRNAs as novel tumor markers has been the focus of much recent attention due to their tissue specificity and unique ability to predict clinicopathological parameters with superior accuracy to mRNA expression profiling. Recent reports have documented altered serum or plasma miRNAs in a variety of cancers including prostate, colon, lung and breast. However it is unknown whether the specific miRNAs reported to be altered in these studies are tumor specific or a general cancer phenomenon. We wished to determine whether a panel of 9 circulating ‘oncomirs’ were tumor specific or similarly expressed in all cancers, and thus identify systemic miRNA signatures predictive of specific cancers.Methods:Using a real-time quantitative PCR approach, expression levels of a panel of 9 oncogenic miRNAs were quantified in blood specimens from 163 cancer patients (breast, colon, renal, prostate and melanoma) and 44 age-matched disease free control individuals. Advanced QBase Plus software and SPSS were used for biostatistical analysis of the data, and correlation with clinicopathological variables.Results:Our panel of circulating miRNAs were detectable at various levels in the circulation of all cancer patients. Expression of general oncomirs such as let 7a and miR-21 were similarly expressed in all cancers. However other specific miRNAs were remarkably different between cancer types. MiR-10b and miR-145 were significantly decreased in the circulation of colon cancer patients compared to other cancers (p=0.000 and p=0.017 respectively). MiR-195, miR-342 and miR-181c were found to be breast cancer specific; elevated levels of these three miRNAs could reliably differentiate breast cancer patients from healthy controls and from patients with other malignancies with high sensitivities (area under curve by ROC analysis: 0.941, 0.963, and 0.926 respectively). Furthermore, systemic miR-195 was detectable in patients with in-situ disease, levels increased progressively as stage of disease advanced, and decreased significantly post curative tumor resection to levels comparable with controls (p=0.001).Conclusion:These findings suggest that individual malignancies, in particular breast cancers, display specific systemic miRNAs profiles, which could aid in early diagnosis and in discriminating one cancer from another. This is of major clinical importance as it illustrates the potential for systemic miRNAs as sensitive and specific yet non-invasive cancer biomarkers.Note: This abstract was not presented at the AACR 101st Annual Meeting 2010 because the presenter was unable to attend.Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 814." @default.
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• W2038240423 date "2010-04-15" @default.
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• W2038240423 title "Abstract 814: A systemic miRNA signature predictive of early breast cancer" @default.
• W2038240423 doi "https://doi.org/10.1158/1538-7445.am10-814" @default.
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