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- W2038250963 abstract "The aim of study is to investigate the effect of nifedipine on viral myocarditis in an animal model. Four-week-old male DBA/2 mice were inoculated with 2 pfu of encephalomyocarditis virus (EMCV) and randomized to nifedipine (n = 10) or control (n = 10) group. The control group was fed by regular chow and the nifedipine group contained 0.01% of nifedipine. Mast cell density was counted, and expressions of messenger RNAs of stem cell factor (SCF), matrix metalloproteinases (MMPs), pro-collagen I, mast cell proteases, tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) were evaluated by RT-PCR. The area of myocardial necrosis was smaller in the nifedipine vs the control group (mean ± SD, 1.2 ± 1.3% vs 3.8 ± 1.8%, respectively, P < 0.005). The mast cell density (count/mm2) was lower in the nifedipine vs the control group (mean ± SD, 0.23 ± 0.16 vs 1.08 ± 0.45, respectively, P < 0.0005). The expressions of MMPs, mast cell proteases, TNF-α, IL-6, SCF and pro-collagen I were lower in the nifedipine group than in the control group (P < 0.05). Nifedipine inhibited the activation of various participants in inflammatory and immune reactions in EMCV myocarditis." @default.
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- W2038250963 date "2009-07-01" @default.
- W2038250963 modified "2023-09-24" @default.
- W2038250963 title "Nifedipine inhibits the activation of inflammatory and immune reactions in viral myocarditis" @default.
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- W2038250963 doi "https://doi.org/10.1016/j.lfs.2009.05.018" @default.
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