Matches in SemOpenAlex for { <https://semopenalex.org/work/W2038252960> ?p ?o ?g. }
- W2038252960 endingPage "386" @default.
- W2038252960 startingPage "381" @default.
- W2038252960 abstract "Hypercholesterolemia is a risk factor for the development of hypertrophic cardiomyopathy. Nevertheless, there are few studies aimed at determining the effects of dietary compounds on early or mild cardiac hypertrophy associated with dyslipidemia. Here we describe left ventricular (LV) hypertrophy in 12 week-old Apo E−/− hypercholesterolemic mice. The LV end diastolic posterior wall thickness and overall LV mass were significantly increased in Apo E−/− mice compared with wild type (WT) controls. Fractional shortening, LV end diastolic diameter, and hemodynamic parameters were unchanged from WT mice. Oral low dose quercetin (QCN; 0.1 µmol QCN/kg body weight for 6 weeks) significantly reduced total cholesterol and very low density lipoprotein in the plasma of Apo E−/− mice. QCN treatment also significantly decreased LV posterior wall thickness and LV mass in Apo E−/− mice. Myocardial geometry and function were unaffected in WT mice by QCN treatment. These data suggest that dietary polyphenolic compounds such as QCN may be effective modulators of plasma cholesterol and could prevent maladaptive myocardial remodeling." @default.
- W2038252960 created "2016-06-24" @default.
- W2038252960 creator A5001874713 @default.
- W2038252960 creator A5002121194 @default.
- W2038252960 creator A5004816474 @default.
- W2038252960 creator A5007073300 @default.
- W2038252960 creator A5011003263 @default.
- W2038252960 creator A5015819680 @default.
- W2038252960 creator A5022992212 @default.
- W2038252960 creator A5053149684 @default.
- W2038252960 creator A5062506120 @default.
- W2038252960 creator A5062920055 @default.
- W2038252960 creator A5075006535 @default.
- W2038252960 date "2013-01-01" @default.
- W2038252960 modified "2023-10-01" @default.
- W2038252960 title "Quercetin prevents left ventricular hypertrophy in the Apo E knockout mouse" @default.
- W2038252960 cites W1861932357 @default.
- W2038252960 cites W1984026843 @default.
- W2038252960 cites W1985475179 @default.
- W2038252960 cites W2006949479 @default.
- W2038252960 cites W2022891472 @default.
- W2038252960 cites W2030611352 @default.
- W2038252960 cites W2048890665 @default.
- W2038252960 cites W2051560454 @default.
- W2038252960 cites W2056667035 @default.
- W2038252960 cites W2056757096 @default.
- W2038252960 cites W2068066319 @default.
- W2038252960 cites W2072384117 @default.
- W2038252960 cites W2083310921 @default.
- W2038252960 cites W2090967770 @default.
- W2038252960 cites W2097632876 @default.
- W2038252960 cites W2110589919 @default.
- W2038252960 cites W2119593272 @default.
- W2038252960 cites W2123123601 @default.
- W2038252960 cites W2125980510 @default.
- W2038252960 cites W2132802442 @default.
- W2038252960 cites W2135136607 @default.
- W2038252960 cites W2138595118 @default.
- W2038252960 cites W2140504563 @default.
- W2038252960 cites W2144072525 @default.
- W2038252960 cites W2147133145 @default.
- W2038252960 cites W2149483801 @default.
- W2038252960 cites W2150569822 @default.
- W2038252960 cites W2150979022 @default.
- W2038252960 cites W2152323915 @default.
- W2038252960 cites W2152727043 @default.
- W2038252960 cites W2153673527 @default.
- W2038252960 cites W2162382529 @default.
- W2038252960 cites W2164127689 @default.
- W2038252960 cites W2167351837 @default.
- W2038252960 cites W2170465739 @default.
- W2038252960 doi "https://doi.org/10.1016/j.redox.2013.07.001" @default.
- W2038252960 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3757709" @default.
- W2038252960 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24024175" @default.
- W2038252960 hasPublicationYear "2013" @default.
- W2038252960 type Work @default.
- W2038252960 sameAs 2038252960 @default.
- W2038252960 citedByCount "26" @default.
- W2038252960 countsByYear W20382529602014 @default.
- W2038252960 countsByYear W20382529602015 @default.
- W2038252960 countsByYear W20382529602016 @default.
- W2038252960 countsByYear W20382529602017 @default.
- W2038252960 countsByYear W20382529602018 @default.
- W2038252960 countsByYear W20382529602020 @default.
- W2038252960 countsByYear W20382529602021 @default.
- W2038252960 crossrefType "journal-article" @default.
- W2038252960 hasAuthorship W2038252960A5001874713 @default.
- W2038252960 hasAuthorship W2038252960A5002121194 @default.
- W2038252960 hasAuthorship W2038252960A5004816474 @default.
- W2038252960 hasAuthorship W2038252960A5007073300 @default.
- W2038252960 hasAuthorship W2038252960A5011003263 @default.
- W2038252960 hasAuthorship W2038252960A5015819680 @default.
- W2038252960 hasAuthorship W2038252960A5022992212 @default.
- W2038252960 hasAuthorship W2038252960A5053149684 @default.
- W2038252960 hasAuthorship W2038252960A5062506120 @default.
- W2038252960 hasAuthorship W2038252960A5062920055 @default.
- W2038252960 hasAuthorship W2038252960A5075006535 @default.
- W2038252960 hasBestOaLocation W20382529601 @default.
- W2038252960 hasConcept C126322002 @default.
- W2038252960 hasConcept C134018914 @default.
- W2038252960 hasConcept C164705383 @default.
- W2038252960 hasConcept C167414201 @default.
- W2038252960 hasConcept C170493617 @default.
- W2038252960 hasConcept C178853913 @default.
- W2038252960 hasConcept C182704531 @default.
- W2038252960 hasConcept C2776002628 @default.
- W2038252960 hasConcept C2776835912 @default.
- W2038252960 hasConcept C2778096610 @default.
- W2038252960 hasConcept C2778163477 @default.
- W2038252960 hasConcept C2778198053 @default.
- W2038252960 hasConcept C2779537366 @default.
- W2038252960 hasConcept C511355011 @default.
- W2038252960 hasConcept C57900726 @default.
- W2038252960 hasConcept C62746215 @default.
- W2038252960 hasConcept C71924100 @default.
- W2038252960 hasConcept C84393581 @default.
- W2038252960 hasConceptScore W2038252960C126322002 @default.
- W2038252960 hasConceptScore W2038252960C134018914 @default.