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• W2038261146 startingPage "238" @default.
• W2038261146 abstract "The system governing extracellular calcium (Ca2+o) homeostasis maintains near constancy of Ca2+o so as to ensure continual availability of calcium ions for their numerous intracellular and extracellular roles. In contrast to the intracellular ionized calcium concentration (Ca2+i), which varies substantially during intracellular signaling via this key second messenger, Ca2+o remains nearly invariant. Yet there must be a mechanism that senses small changes in Ca2+o so as to set into motion the homeostatic responses that return Ca2+o to its normal level. The recent identification and molecular cloning of the mechanism through which parathyroid cells and a number of other cell types sense Ca2+o, a G protein-coupled Ca2+o-sensing receptor (CaR), has proven unequivocally that extracellular calcium ions serve in an informational capacity. The CaR permits Ca2+o to function in a hormone-like role as an extracellular first messenger through which parathyroid, kidney, and other cells communicate with one another via the CaR. The identification of inherited human hypercalcemic and hypocalcemic disorders arising from inactivating and activating mutations of the CaR, respectively, has provided additional proof of the essential, nonredundant role of the CaR in mineral ion homeostasis. Moreover, CaR-active drugs are currently in clinical trials for the treatment of primary and uremic hyperparathyroidism, disorders in which there are acquired, tissue-specific reductions in CaR expression and, in turn, defective Ca2+o-sensing by pathological parathyroid cells. No doubt further studies of Ca2+o-sensing by the CaR will reveal additional functions of Ca2+o, not only as a systemic hormone but also in local, paracrine, and autocrine signaling through this novel Ca2+o-sensing receptor." @default.
• W2038261146 created "2016-06-24" @default.
• W2038261146 creator A5038281830 @default.
• W2038261146 date "1999-02-01" @default.
• W2038261146 modified "2023-10-10" @default.
• W2038261146 title "Physiology and pathophysiology of the extracellular calcium-sensing receptor" @default.
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• W2038261146 cites W1753116283 @default.
• W2038261146 cites W1853215604 @default.
• W2038261146 cites W1966419963 @default.
• W2038261146 cites W1969540263 @default.
• W2038261146 cites W1969619665 @default.
• W2038261146 cites W1971284998 @default.
• W2038261146 cites W1972065681 @default.
• W2038261146 cites W1972376675 @default.
• W2038261146 cites W1972476373 @default.
• W2038261146 cites W1975367389 @default.
• W2038261146 cites W1977019491 @default.
• W2038261146 cites W1984252569 @default.
• W2038261146 cites W1994723791 @default.
• W2038261146 cites W2006020017 @default.
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• W2038261146 cites W2010599278 @default.
• W2038261146 cites W2011539758 @default.
• W2038261146 cites W2015547112 @default.
• W2038261146 cites W2016094313 @default.
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• W2038261146 cites W2036976619 @default.
• W2038261146 cites W2042484533 @default.
• W2038261146 cites W2047907147 @default.
• W2038261146 cites W2060757756 @default.
• W2038261146 cites W2062355922 @default.
• W2038261146 cites W2065390805 @default.
• W2038261146 cites W2066125438 @default.
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• W2038261146 cites W2069454620 @default.
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• W2038261146 cites W2078643685 @default.
• W2038261146 cites W2079475485 @default.
• W2038261146 cites W2081227689 @default.
• W2038261146 cites W2086486301 @default.
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• W2038261146 cites W2102108938 @default.
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• W2038261146 doi "https://doi.org/10.1016/s0002-9343(98)00418-5" @default.
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• W2038261146 hasPublicationYear "1999" @default.
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