FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2038264829> ?p ?o ?g. }

• W2038264829 endingPage "1354" @default.
• W2038264829 startingPage "1339" @default.
• W2038264829 abstract "Direct drug delivery to the cochlea is associated with the risk of irreversible damage to the ear. In this study, liposome and polymersome nanoparticles (NPs), both formed from amphiphilic molecules (lipids in liposomes and block copolymers in polymersomes), were tested as potential tools for drug delivery to the cochlea via application onto the round window membrane in adult mice (strain C3H). One day after round window membrane application, both types of NPs labeled with fluorescent markers were identified in the spiral ganglion in all cochlear turns without producing any distinct morphological or functional damage to the inner ear. NPs were detected, although to a lesser extent, in the organ of Corti and the lateral wall. The potential of liposome and polymersome NPs as therapeutic delivery systems into the cochlea via the round window membrane was evaluated using disulfiram, a neurotoxic agent, as a model payload. Disulfiram-loaded NP delivery resulted in a significant decrease in the number of spiral ganglion cells starting 2 days postapplication, with associated pronounced hearing loss reaching 20–35 dB 2 weeks postapplication as assessed through auditory brainstem responses. No changes in hair cell morphology and function (as assessed by recording otoacoustic emissions) were detected after disulfiram-loaded NP application. No effects were observed in controls where solution of free disulfiram was similarly administered. The results demonstrate that liposome and polymersome NPs are capable of carrying a payload into the inner ear that elicits a biological effect, with consequences measurable by a functional readout. Original submitted 15 March 2011; Revised submitted 4 January 2012; Published online 4 April 2012" @default.
• W2038264829 created "2016-06-24" @default.
• W2038264829 creator A5002034165 @default.
• W2038264829 creator A5003391837 @default.
• W2038264829 creator A5030331075 @default.
• W2038264829 creator A5045007459 @default.
• W2038264829 creator A5061878537 @default.
• W2038264829 creator A5066369911 @default.
• W2038264829 creator A5078254785 @default.
• W2038264829 creator A5078596818 @default.
• W2038264829 creator A5085226363 @default.
• W2038264829 date "2012-09-01" @default.
• W2038264829 modified "2023-10-16" @default.
• W2038264829 title "Minimally invasive drug delivery to the cochlea through application of nanoparticles to the round window membrane" @default.
• W2038264829 cites W1969221205 @default.
• W2038264829 cites W1984568759 @default.
• W2038264829 cites W1986088298 @default.
• W2038264829 cites W1989761558 @default.
• W2038264829 cites W1990427469 @default.
• W2038264829 cites W1993062055 @default.
• W2038264829 cites W1997416568 @default.
• W2038264829 cites W1999035515 @default.
• W2038264829 cites W2000453687 @default.
• W2038264829 cites W2002875893 @default.
• W2038264829 cites W2004043082 @default.
• W2038264829 cites W2011182544 @default.
• W2038264829 cites W2014790842 @default.
• W2038264829 cites W2014808977 @default.
• W2038264829 cites W2018241677 @default.
• W2038264829 cites W2020107073 @default.
• W2038264829 cites W2033750023 @default.
• W2038264829 cites W2036180531 @default.
• W2038264829 cites W2037480079 @default.
• W2038264829 cites W2044296714 @default.
• W2038264829 cites W2044569715 @default.
• W2038264829 cites W2049589135 @default.
• W2038264829 cites W2055108649 @default.
• W2038264829 cites W2055591179 @default.
• W2038264829 cites W2063680364 @default.
• W2038264829 cites W2065030592 @default.
• W2038264829 cites W2065903443 @default.
• W2038264829 cites W2071969529 @default.
• W2038264829 cites W2072341873 @default.
• W2038264829 cites W2077286615 @default.
• W2038264829 cites W2077694960 @default.
• W2038264829 cites W2085892145 @default.
• W2038264829 cites W2087132034 @default.
• W2038264829 cites W2089721045 @default.
• W2038264829 cites W2095571709 @default.
• W2038264829 cites W2105459755 @default.
• W2038264829 cites W2106875648 @default.
• W2038264829 cites W2108719719 @default.
• W2038264829 cites W2116004651 @default.
• W2038264829 cites W2138468247 @default.
• W2038264829 cites W2145089342 @default.
• W2038264829 cites W2154345821 @default.
• W2038264829 cites W2162607898 @default.
• W2038264829 cites W2176417291 @default.
• W2038264829 cites W2302267746 @default.
• W2038264829 cites W2335253612 @default.
• W2038264829 cites W2336994782 @default.
• W2038264829 cites W4230579910 @default.
• W2038264829 cites W4294730393 @default.
• W2038264829 doi "https://doi.org/10.2217/nnm.12.5" @default.
• W2038264829 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22475648" @default.
• W2038264829 hasPublicationYear "2012" @default.
• W2038264829 type Work @default.
• W2038264829 sameAs 2038264829 @default.
• W2038264829 citedByCount "65" @default.
• W2038264829 countsByYear W20382648292012 @default.
• W2038264829 countsByYear W20382648292013 @default.
• W2038264829 countsByYear W20382648292014 @default.
• W2038264829 countsByYear W20382648292015 @default.
• W2038264829 countsByYear W20382648292016 @default.
• W2038264829 countsByYear W20382648292017 @default.
• W2038264829 countsByYear W20382648292018 @default.
• W2038264829 countsByYear W20382648292019 @default.
• W2038264829 countsByYear W20382648292020 @default.
• W2038264829 countsByYear W20382648292021 @default.
• W2038264829 countsByYear W20382648292022 @default.
• W2038264829 crossrefType "journal-article" @default.
• W2038264829 hasAuthorship W2038264829A5002034165 @default.
• W2038264829 hasAuthorship W2038264829A5003391837 @default.
• W2038264829 hasAuthorship W2038264829A5030331075 @default.
• W2038264829 hasAuthorship W2038264829A5045007459 @default.
• W2038264829 hasAuthorship W2038264829A5061878537 @default.
• W2038264829 hasAuthorship W2038264829A5066369911 @default.
• W2038264829 hasAuthorship W2038264829A5078254785 @default.
• W2038264829 hasAuthorship W2038264829A5078596818 @default.
• W2038264829 hasAuthorship W2038264829A5085226363 @default.
• W2038264829 hasConcept C105702510 @default.
• W2038264829 hasConcept C12554922 @default.
• W2038264829 hasConcept C136229726 @default.
• W2038264829 hasConcept C15083742 @default.
• W2038264829 hasConcept C155672457 @default.
• W2038264829 hasConcept C15920480 @default.
• W2038264829 hasConcept C171250308 @default.
• W2038264829 hasConcept C178790620 @default.

• next